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ClinicalTrials.gov 43 recruiting now official registry

Carcinoma, Non-Small Cell Lung clinical trials

43 of 133 indexed Carcinoma, Non-Small Cell Lung trials are currently recruiting.

133 US clinical trials · 43 currently recruiting

Carcinoma, Non-Small Cell Lung is the subject of 133 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is Pfizer, running 14 of these trials.

The research picture

Carcinoma, Non-Small Cell Lung has 133 registered US clinical trials, 43 of them open to new participants right now, about 32% of the total.

43
recruiting participants now
32%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
14
top sponsor: Pfizer
Phase 158Phase 234Phase 327

Active & Recent Trials

133 total, page 1 of 3

RECRUITING 7,500 participants

MYLUNG Consortium Part 3: Observational Study

US Oncology Research

NCT05885698

RECRUITING Phase 3 1,410 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pfizer

NCT07222566

RECRUITING Phase 3 1,264 participants

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Eli Lilly and Company

NCT06119581

RECRUITING 1,065 participants

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Merck Sharp & Dohme

NCT04165798

RECRUITING Phase 1 1,006 participants

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT04389632

RECRUITING Phase 1 914 participants

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06131840

RECRUITING Phase 3 830 participants

A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

AstraZeneca

NCT06868277

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 3 714 participants

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Pfizer

NCT06758401

RECRUITING Phase 3 700 participants

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Eli Lilly and Company

NCT06890598

RECRUITING Phase 3 680 participants

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Merck Sharp & Dohme

NCT06623422

RECRUITING Phase 3 630 participants

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

Mirati Therapeutics

NCT06875310

RECRUITING Phase 1 540 participants

Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)

Eli Lilly and Company

NCT04956640

RECRUITING Phase 2 520 participants

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Janssen Research & Development

NCT05498428

RECRUITING Phase 1 495 participants

A Study of LY4170156 in Participants With Selected Advanced Solid Tumors

Eli Lilly and Company

NCT06400472

RECRUITING Phase 2 480 participants

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Janssen Research & Development

NCT06667076

RECRUITING Phase 1 450 participants

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Merck Sharp & Dohme

NCT04165070

RECRUITING Phase 1 403 participants

First in Human Study of AZD9592 in Solid Tumors

AstraZeneca

NCT05647122

RECRUITING Phase 1 330 participants

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Pfizer

NCT06447662

RECRUITING Phase 1 310 participants

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Pfizer

NCT07090499

RECRUITING Phase 2 300 participants

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

Janssen Research & Development

NCT06120140

RECRUITING Phase 3 280 participants

A Study to Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

AstraZeneca

NCT06008093

RECRUITING Phase 1 240 participants

A Study of LY4175408 in Participants With Advanced Cancer

Eli Lilly and Company

NCT07046923

RECRUITING NA 208 participants

Confocal Laser Endomicroscopy VERification

Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

NCT06079970

RECRUITING 200 participants

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)

Travera

NCT05461430

RECRUITING Phase 1 162 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

Pfizer

NCT07227298

RECRUITING Phase 1 158 participants

Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib

Genprex

NCT04486833

RECRUITING Phase 1 136 participants

A Study of DM005 in Patients With Advanced Solid Tumors

Doma Biopharmaceutical(Suzhou)Co.

NCT06515990

RECRUITING Phase 2 130 participants

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

Johnson & Johnson Enterprise Innovation

NCT06667908

RECRUITING Phase 2 130 participants

A Study of BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)

Bristol-Myers Squibb

NCT06855771

RECRUITING Phase 1 128 participants

A Study of DM001 in Patients With Advanced Solid Tumors

Xadcera Biopharmaceutical (Suzhou) Co.

NCT06475937

RECRUITING Phase 1 126 participants

A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer

Johnson & Johnson Enterprise Innovation

NCT06116786

RECRUITING Phase 2 112 participants

Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

Weill Medical College of Cornell University

NCT06623656

RECRUITING Phase 2 108 participants

Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy

Hackensack Meridian Health

NCT05715229

RECRUITING 100 participants

Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

University of Colorado, Denver

NCT03958565

RECRUITING 100 participants

Development and Analysis of a Stool Bank for Cancer Patients

Persephone Biosciences

NCT04291755

RECRUITING Phase 2 96 participants

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Merck Sharp & Dohme

NCT06780085

RECRUITING Phase 2 90 participants

A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma

Lantern Pharma

NCT05456256

RECRUITING NA 70 participants

Patient-centered, Optimal Integration of Survivorship and Palliative Care

Massachusetts General Hospital

NCT04900935

RECRUITING Phase 1 60 participants

A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer

Janssen Research & Development

NCT07227025

RECRUITING Phase 2 30 participants

Osimertinib In EGFR Mutant Lung Cancer

Dana-Farber Cancer Institute

NCT03586453

RECRUITING Phase 2 18 participants

Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

Georgetown University

NCT04499053

RECRUITING Phase 1 15 participants

Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer

The Methodist Hospital Research Institute

NCT06566443

ACTIVE NOT RECRUITING Phase 3 1,074 participants

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Janssen Research & Development

NCT04487080

ACTIVE NOT RECRUITING 1,002 participants

MYLUNG Consortium Study Protocol 2

US Oncology Research

NCT05644808

ACTIVE NOT RECRUITING Phase 3 870 participants

Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)

Merck Sharp & Dohme

NCT04380636

ACTIVE NOT RECRUITING Phase 3 776 participants

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

Janssen Research & Development

NCT04988295

ACTIVE NOT RECRUITING Phase 3 724 participants

Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

AstraZeneca

NCT03833154

ACTIVE NOT RECRUITING Phase 3 703 participants

A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

Seagen, a wholly owned subsidiary of Pfizer

NCT06012435

ACTIVE NOT RECRUITING Phase 1 701 participants

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

Janssen Research & Development

NCT04077463

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Phase Distribution

PhaseTrial count
Phase 1 58
Phase 2 34
Phase 3 27

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Carcinoma, Non-Small Cell Lung Trial Landscape

133 indexed Carcinoma, Non-Small Cell Lung studies · 43 recruiting (32%).

Phase mix: 27 late (III/IV) vs 92 early (I/II).

Top sponsor: Pfizer (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Carcinoma, Non-Small Cell Lung?

PlainTrial tracks 133 US clinical trials for Carcinoma, Non-Small Cell Lung, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Carcinoma, Non-Small Cell Lung?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.