Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT07218133 · ClinicalTrials.gov registry record · NA

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

A NA study of Inflammation and Hyperglycemia, sponsored by Alexander T. Yahanda.

Recruiting
Registry status
NA
Development phase
50
Enrollment target
1
Study location

NCT07218133: Recruiting NA study of Inflammation and Hyperglycemia, sponsored by Alexander T. Yahanda.

NCT07218133 is a NA study of Inflammation and Hyperglycemia that is actively recruiting participants, run by Alexander T. Yahanda. The registered enrollment target is 50 participants, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT07218133, a NA study of Inflammation and Hyperglycemia, is actively recruiting participants, sponsored by Alexander T. Yahanda.

RECRUITING
Registry status
NA
Development phase
50 participants
Enrollment target
1
Study location

Study Summary

This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.

Primary Outcome

The levels of 4 different inflammatory cytokines will be measured: interleukin-6 (IL-6), IL-1, IL-10, and tumor necrosis factor alpha (TNF-a) (all measured in pg/ml). Blood for these tests will be drawn preoperatively, postoperatively, on postop day 3, and postop day 6 (or time of discharge).

Conditions Studied

Inflammation Hyperglycemia Spinal Fusion Neurological Disorder Postoperative Pain Management Postoperative Care Spine Disease Neurologic Deficits Spine Condition Spinal (Fusion) Surgery

Interventions

  • DEVICE Sham Auricular Vagus nerve Stimulation
  • DEVICE Auricular vagus nerve stimulation

Study Locations (1)

Missouri

  • Washington University School of Medicine - St Louis

Trial Details

FieldValue
Enrollment Target 50 participants
Start Date 2025-10-08
Est. Completion 2026-12
Phase NA
Alexander T. Yahanda

1 total trials

What NCT07218133 shows while recruiting

NCT07218133 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 288-participant average among 132 other Inflammation trials with a reported enrollment target (83% lower).

The record links to 10 conditions, with Inflammation appearing as the primary indexed condition, and to 2 interventions - of which Sham Auricular Vagus nerve Stimulation is the first listed.

NCT07218133 reports a single indexed study location in Missouri.

Frequently Asked Questions

What is clinical trial NCT07218133 about?

NCT07218133 is a clinical study titled "Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery". This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current ac...

What is the current status of trial NCT07218133?

This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2025-10-08. Estimated completion is 2026-12.

What conditions does trial NCT07218133 study?

This clinical trial studies the following conditions: Inflammation, Hyperglycemia, Spinal Fusion, Neurological Disorder, Postoperative Pain Management.

What interventions are being tested in trial NCT07218133?

The interventions under investigation include: Sham Auricular Vagus nerve Stimulation (DEVICE), Auricular vagus nerve stimulation (DEVICE).

Who is sponsoring clinical trial NCT07218133?

This trial is sponsored by Alexander T. Yahanda, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07218133 being conducted?

This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Inflammation

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07218133's enrollment target sits among peer trials

50 74th of 132 higher than 58 of 132 other Inflammation trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Inflammation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT00200889 · 50 participants · Early Phase 1

    Mapping Auricular Vagus Nerve Circuitry

  • NCT00409435 · 50 participants · Phase 2

    A Study of Pyridostigmine in Postural Tachycardia Syndrome

  • NCT01202305 · 50 participants

    The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

  • NCT01225913 · 50 participants · Phase 4

    Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

More recruiting context for NCT07218133

Source: ClinicalTrials.gov NCT07218133, the US trial registry maintained by the National Library of Medicine. NCT07218133 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.