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HIV clinical trials
109 of 304 indexed HIV trials are currently recruiting.
304 US clinical trials · 109 currently recruiting
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
The research picture
HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.
- 109
- recruiting participants now
- 36%
- of trials open to enrollment
- 25
- in Phase 3–4 (later-stage)
- 24
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
304 total, page 3 of 7
Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
University of Maryland, Baltimore
NCT06691243
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide
Yale University
NCT07040592
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH
Gopalkumar Rakesh
NCT06830980
Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV
University of Washington
NCT07105007
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1
Yale University
NCT06004830
HIV, Equity, and Addiction Training (HEAT) Program
University of Alabama at Birmingham
NCT06370481
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2
Yale University
NCT06006143
Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD
Montefiore Medical Center
NCT05929911
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
University of Hawaii
NCT06935838
ED2PrEP - Patient Focused, Low-burden Strategies for PrEP Uptake Among Emergency Departments
Albert Einstein College of Medicine
NCT05588193
Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program
City University of New York
NCT05140421
Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV
University of California, San Francisco
NCT04795219
Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use
University of Chicago
NCT06682468
Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence
Washington University School of Medicine
NCT01790373
Nonalcoholic Fatty Liver Disease in HIV Database
Johns Hopkins University
NCT05023044
Parent-focused Intervention to Reduce HIV Risk in Gay and Bisexual Adolescents
George Washington University
NCT05852600
Adherence and Clinical Correlates in Persons With HIV on TAF
University of Colorado, Denver
NCT05335590
Selection of a Protective T Cell-based HIV-1/FIV Vaccine
University of Florida
NCT02389595
Physical Activity for PLWH and Unhealthy Drinking
Boston University
NCT05505942
A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic Suppression Who Switch to DTG/3TC FDC From BIC/FTC/TAF
ViiV Healthcare
NCT05911360
PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04926922
Effectiveness of Zidovudine vs. Zidovudine Plus Alpha Interferon vs. Interferon for Treatment of HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01125228
The HIV, Adipose Tissue Immunology, and Metabolism Study
Vanderbilt University Medical Center
NCT04451980
Oral Dronabinol-HIV
Yale University
NCT06034314
Promoting Employment in Persons Living With HIV/AIDS
UConn Health
NCT03959826
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Weill Medical College of Cornell University
NCT05382208
High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV
University of Colorado, Denver
NCT04550676
Standing Tall (Yima Nkqo)
Brigham and Women's Hospital
NCT04568460
Cisgender Female Patients Who Start on Long Acting Cabotegravir for PrEP
Midway Specialty Care Center
NCT06145854
Tell Me More ("Dime Mas")
University of Miami
NCT06063083
HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients
Johns Hopkins University
NCT03734393
Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
National Cancer Institute (NCI)
NCT00092222
Immediate Initiation of Antiretroviral Therapy During "Hyperacute" HIV Infection
University of California, San Francisco
NCT02656511
Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances
Friends Research Institute
NCT05704764
Emtricitabine/Tenofovir Alafenamide Switch Study for Transgender Individuals for HIV Pre-exposure Prophylaxis
University of California, San Diego
NCT04616963
A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06033209
A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) and Core-g28v2 60mer mRNA Vaccine (mRNA-1644v2-Core)
International AIDS Vaccine Initiative
NCT05001373
Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs
Yale University
NCT06411223
Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of 16055 NFL Delta Gly4 Env Protein Trimer and Trimer 4571 Combined With 3M-052-AF + Alum Adjuvant and Ad4-Env145NFL Viral Particles as Heterologous Prime-boost Regimens in Adult Participants Without HIV.
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06332339
Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity
University of California, San Diego
NCT04800159
Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults
Boris Juelg, MD PhD
NCT04983030
Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05903339
Safety and Survival of Genetically Modified White Blood Cells in HIV-infected Twins The Gemini Study
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04799483
Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing
Harvard Pilgrim Health Care
NCT06805877
Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients
City of Hope Medical Center
NCT02500849
Using CBPR to Engage Hazardous Drinking Women in the HIV Prevention and Care Continuum
Johns Hopkins University
NCT04090723
CD4 CAR+ ZFN-modified T Cells in HIV Therapy
University of Pennsylvania
NCT03617198
Implementation of Collaborative Care for Depression in VA HIV Clinics
VA Office of Research and Development
NCT05901272
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
University of California, San Francisco
NCT03217058
Assisted Partner Services and HIVST in Western Kenya
University of Washington
NCT04774835
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Trial Landscape
304 indexed HIV studies · 109 recruiting (36%).
Phase mix: 25 late (III/IV) vs 64 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV?
PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.