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ClinicalTrials.gov 109 recruiting now official registry

HIV clinical trials

109 of 304 indexed HIV trials are currently recruiting.

304 US clinical trials · 109 currently recruiting

HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.

The research picture

HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.

109
recruiting participants now
36%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
24
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 132Phase 232Phase 312Phase 413

Active & Recent Trials

304 total, page 3 of 7

RECRUITING Phase 2 40 participants

Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV

University of Maryland, Baltimore

NCT06691243

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

Yale University

NCT07040592

RECRUITING NA 30 participants

Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

Gopalkumar Rakesh

NCT06830980

RECRUITING NA 30 participants

Proof-of-concept of a Behavioral Intervention to Improve the Cardiovascular Health of People Living With HIV

University of Washington

NCT07105007

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1

Yale University

NCT06004830

RECRUITING NA 30 participants

HIV, Equity, and Addiction Training (HEAT) Program

University of Alabama at Birmingham

NCT06370481

RECRUITING Phase 2 30 participants

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

Yale University

NCT06006143

RECRUITING NA 20 participants

Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Montefiore Medical Center

NCT05929911

RECRUITING Phase 2 12 participants

Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV

University of Hawaii

NCT06935838

ACTIVE NOT RECRUITING NA 1,560 participants

ED2PrEP - Patient Focused, Low-burden Strategies for PrEP Uptake Among Emergency Departments

Albert Einstein College of Medicine

NCT05588193

ACTIVE NOT RECRUITING NA 1,494 participants

Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

City University of New York

NCT05140421

ACTIVE NOT RECRUITING 1,250 participants

Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV

University of California, San Francisco

NCT04795219

ACTIVE NOT RECRUITING NA 900 participants

Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

University of Chicago

NCT06682468

ACTIVE NOT RECRUITING NA 702 participants

Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence

Washington University School of Medicine

NCT01790373

ACTIVE NOT RECRUITING 400 participants

Nonalcoholic Fatty Liver Disease in HIV Database

Johns Hopkins University

NCT05023044

ACTIVE NOT RECRUITING NA 393 participants

Parent-focused Intervention to Reduce HIV Risk in Gay and Bisexual Adolescents

George Washington University

NCT05852600

ACTIVE NOT RECRUITING 384 participants

Adherence and Clinical Correlates in Persons With HIV on TAF

University of Colorado, Denver

NCT05335590

ACTIVE NOT RECRUITING 270 participants

Selection of a Protective T Cell-based HIV-1/FIV Vaccine

University of Florida

NCT02389595

ACTIVE NOT RECRUITING NA 222 participants

Physical Activity for PLWH and Unhealthy Drinking

Boston University

NCT05505942

ACTIVE NOT RECRUITING Phase 3 205 participants

A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic Suppression Who Switch to DTG/3TC FDC From BIC/FTC/TAF

ViiV Healthcare

NCT05911360

ACTIVE NOT RECRUITING 200 participants

PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04926922

ACTIVE NOT RECRUITING 180 participants

Effectiveness of Zidovudine vs. Zidovudine Plus Alpha Interferon vs. Interferon for Treatment of HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01125228

ACTIVE NOT RECRUITING 172 participants

The HIV, Adipose Tissue Immunology, and Metabolism Study

Vanderbilt University Medical Center

NCT04451980

ACTIVE NOT RECRUITING Phase 1 160 participants

Oral Dronabinol-HIV

Yale University

NCT06034314

ACTIVE NOT RECRUITING NA 144 participants

Promoting Employment in Persons Living With HIV/AIDS

UConn Health

NCT03959826

ACTIVE NOT RECRUITING Phase 2 133 participants

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Weill Medical College of Cornell University

NCT05382208

ACTIVE NOT RECRUITING NA 118 participants

High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV

University of Colorado, Denver

NCT04550676

ACTIVE NOT RECRUITING Phase 2 100 participants

Standing Tall (Yima Nkqo)

Brigham and Women's Hospital

NCT04568460

ACTIVE NOT RECRUITING 100 participants

Cisgender Female Patients Who Start on Long Acting Cabotegravir for PrEP

Midway Specialty Care Center

NCT06145854

ACTIVE NOT RECRUITING NA 90 participants

Tell Me More ("Dime Mas")

University of Miami

NCT06063083

ACTIVE NOT RECRUITING NA 80 participants

HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients

Johns Hopkins University

NCT03734393

ACTIVE NOT RECRUITING Phase 2 75 participants

Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

National Cancer Institute (NCI)

NCT00092222

ACTIVE NOT RECRUITING Phase 4 74 participants

Immediate Initiation of Antiretroviral Therapy During "Hyperacute" HIV Infection

University of California, San Francisco

NCT02656511

ACTIVE NOT RECRUITING NA 70 participants

Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances

Friends Research Institute

NCT05704764

ACTIVE NOT RECRUITING Phase 4 64 participants

Emtricitabine/Tenofovir Alafenamide Switch Study for Transgender Individuals for HIV Pre-exposure Prophylaxis

University of California, San Diego

NCT04616963

ACTIVE NOT RECRUITING Phase 1 57 participants

A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06033209

ACTIVE NOT RECRUITING Phase 1 56 participants

A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) and Core-g28v2 60mer mRNA Vaccine (mRNA-1644v2-Core)

International AIDS Vaccine Initiative

NCT05001373

ACTIVE NOT RECRUITING Phase 2 50 participants

Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs

Yale University

NCT06411223

ACTIVE NOT RECRUITING Phase 1 45 participants

Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of 16055 NFL Delta Gly4 Env Protein Trimer and Trimer 4571 Combined With 3M-052-AF + Alum Adjuvant and Ad4-Env145NFL Viral Particles as Heterologous Prime-boost Regimens in Adult Participants Without HIV.

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06332339

ACTIVE NOT RECRUITING Phase 2 40 participants

Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity

University of California, San Diego

NCT04800159

ACTIVE NOT RECRUITING Phase 1 36 participants

Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults

Boris Juelg, MD PhD

NCT04983030

ACTIVE NOT RECRUITING Phase 1 36 participants

Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05903339

ACTIVE NOT RECRUITING 32 participants

Safety and Survival of Genetically Modified White Blood Cells in HIV-infected Twins The Gemini Study

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04799483

ACTIVE NOT RECRUITING NA 16 participants

Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

Harvard Pilgrim Health Care

NCT06805877

ACTIVE NOT RECRUITING Phase 1 12 participants

Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients

City of Hope Medical Center

NCT02500849

ACTIVE NOT RECRUITING NA 12 participants

Using CBPR to Engage Hazardous Drinking Women in the HIV Prevention and Care Continuum

Johns Hopkins University

NCT04090723

ACTIVE NOT RECRUITING Phase 1 12 participants

CD4 CAR+ ZFN-modified T Cells in HIV Therapy

University of Pennsylvania

NCT03617198

ACTIVE NOT RECRUITING NA 8 participants

Implementation of Collaborative Care for Depression in VA HIV Clinics

VA Office of Research and Development

NCT05901272

COMPLETED NA 10,821 participants

Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care

University of California, San Francisco

NCT03217058

COMPLETED NA 4,941 participants

Assisted Partner Services and HIVST in Western Kenya

University of Washington

NCT04774835

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 32
Phase 3 12
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Trial Landscape

304 indexed HIV studies · 109 recruiting (36%).

Phase mix: 25 late (III/IV) vs 64 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV?

PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.