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ClinicalTrials.gov 109 recruiting now official registry

HIV clinical trials

109 of 304 indexed HIV trials are currently recruiting.

304 US clinical trials · 109 currently recruiting

HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.

The research picture

HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.

109
recruiting participants now
36%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
24
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 132Phase 232Phase 312Phase 413

Active & Recent Trials

304 total, page 2 of 7

RECRUITING NA 200 participants

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

Washington University School of Medicine

NCT07270406

RECRUITING NA 200 participants

Human Immunodeficiency Virus (HIV) Food Insecurities

Wake Forest University Health Sciences

NCT04943861

RECRUITING 200 participants

Advancing Dignity, Health, and Optimism in Connection With Long Acting Injectables

Mazonson & Santas

NCT05208541

RECRUITING NA 200 participants

Enhancing Wellness Through Affirming Services and Education

Duke University

NCT05700474

RECRUITING NA 200 participants

Increasing PrEP With Trans Women in the Deep South

CrescentCare

NCT05689281

RECRUITING NA 200 participants

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Johns Hopkins University

NCT06263426

RECRUITING NA 196 participants

Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV

Butler Hospital

NCT05752500

RECRUITING NA 195 participants

Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma

University of Florida

NCT05561595

RECRUITING NA 180 participants

Case Management Dyad

University of Chicago

NCT06162897

RECRUITING NA 150 participants

Alcohol Research in HIV: Relapse Prevention

Johns Hopkins University

NCT05163301

RECRUITING 150 participants

Natural History Study of Kaposi Sarcoma

National Cancer Institute (NCI)

NCT06375122

RECRUITING NA 150 participants

SHARE Program: SUSTAIN

Florida State University

NCT06934395

RECRUITING 132 participants

Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

University of Chicago

NCT06894199

RECRUITING Phase 2 120 participants

Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV

University of Maryland, Baltimore

NCT06624839

RECRUITING Phase 2 120 participants

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

Massachusetts General Hospital

NCT05570812

RECRUITING NA 120 participants

Stress and Pain in People Living With HIV

Yale University

NCT06784908

RECRUITING NA 120 participants

PrEP Intervention in Prince George's County, Maryland

George Mason University

NCT06141408

RECRUITING NA 110 participants

Economic Navigation and Strengthening to Research Unrestricted Services for Transgender Women (ENTRUST)

University of Central Florida

NCT06202898

RECRUITING NA 100 participants

1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

Johns Hopkins University

NCT05608421

RECRUITING Phase 4 100 participants

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

University of Alabama at Birmingham

NCT06829238

RECRUITING Phase 4 100 participants

Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

Massachusetts General Hospital

NCT07199335

RECRUITING NA 100 participants

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

Wake Forest University Health Sciences

NCT05858034

RECRUITING 100 participants

Predictors of Health Service Utilizations Among Key Population in Washington DC

Us Helping Us, People Into Living

NCT06046079

RECRUITING 100 participants

The Use of Leukapheresis to Support HIV Pathogenesis Studies

University of California, San Francisco

NCT01161199

RECRUITING NA 100 participants

Improving HIV Care Continuum Outcomes Among Formerly Incarcerated Individuals Through Critical Time Legal Interventions

University of Central Florida

NCT06171919

RECRUITING Phase 1 100 participants

HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)

Yale University

NCT06513819

RECRUITING NA 100 participants

TelePrEP for At-risk Youth in Colorado

University of Colorado, Denver

NCT05520905

RECRUITING Phase 2 90 participants

Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

University of California, San Diego

NCT05514899

RECRUITING Phase 2 80 participants

Improving Physical Ability and Cellular Senescence Elimination in HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT07144293

RECRUITING NA 80 participants

Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama

University of Alabama at Birmingham

NCT05384145

RECRUITING NA 80 participants

Universal Basic Income and Structural Racism in the US South: HIV Care

University of Arkansas

NCT06186128

RECRUITING Phase 4 75 participants

Implementation and Deliver of Lenacapavir for PrEP in a Community Pharmacy Setting

Kelley-Ross & Associates

NCT07210125

RECRUITING NA 72 participants

Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

Brown University

NCT03862924

RECRUITING NA 70 participants

A Study to Improve Skeletal Muscle in Veterans With HIV

VA Office of Research and Development

NCT06845046

RECRUITING Early Phase 1 63 participants

The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease

Vanderbilt University Medical Center

NCT06113003

RECRUITING NA 60 participants

High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV

University of Alabama at Birmingham

NCT05965518

RECRUITING NA 60 participants

Single Session Narrative Therapy Study

University of Washington

NCT06479980

RECRUITING NA 60 participants

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

University of Florida

NCT07112001

RECRUITING Phase 2 60 participants

Inflammation and Depression in People With HIV

Emory University

NCT05849038

RECRUITING NA 56 participants

PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking

University of Alabama at Birmingham

NCT07231640

RECRUITING 55 participants

IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas

University of Nebraska

NCT06451341

RECRUITING NA 55 participants

Expression of Stress Markers During Meth Treatment (EXPRESS+)

University of California, Los Angeles

NCT05558345

RECRUITING NA 50 participants

Assessing Peer Support for Physical Activity in Women With HIV and Hypertension

University of Alabama at Birmingham

NCT07025109

RECRUITING NA 50 participants

HIV Suicide Prevention With AI-DBT

Rutgers, The State University of New Jersey

NCT07339189

RECRUITING 50 participants

The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

University of California, San Francisco

NCT01202305

RECRUITING Phase 2 50 participants

Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption

National Cancer Institute (NCI)

NCT05419024

RECRUITING NA 50 participants

Wellness, Intervention Strategies and HIV Care

University of California, San Francisco

NCT07069374

RECRUITING NA 50 participants

Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

Massachusetts General Hospital

NCT06001814

RECRUITING NA 45 participants

Patient-provider Decision Aid for HIV Post-exposure Prophylaxis Following Sexual Assault

University of Arkansas

NCT06139354

RECRUITING Phase 1 42 participants

Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06796686

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 32
Phase 3 12
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Trial Landscape

304 indexed HIV studies · 109 recruiting (36%).

Phase mix: 25 late (III/IV) vs 64 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV?

PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.