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HIV clinical trials
109 of 304 indexed HIV trials are currently recruiting.
304 US clinical trials · 109 currently recruiting
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
The research picture
HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.
- 109
- recruiting participants now
- 36%
- of trials open to enrollment
- 25
- in Phase 3–4 (later-stage)
- 24
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
304 total, page 2 of 7
Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain
Washington University School of Medicine
NCT07270406
Human Immunodeficiency Virus (HIV) Food Insecurities
Wake Forest University Health Sciences
NCT04943861
Advancing Dignity, Health, and Optimism in Connection With Long Acting Injectables
Mazonson & Santas
NCT05208541
Enhancing Wellness Through Affirming Services and Education
Duke University
NCT05700474
Increasing PrEP With Trans Women in the Deep South
CrescentCare
NCT05689281
Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Johns Hopkins University
NCT06263426
Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV
Butler Hospital
NCT05752500
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
University of Florida
NCT05561595
Case Management Dyad
University of Chicago
NCT06162897
Alcohol Research in HIV: Relapse Prevention
Johns Hopkins University
NCT05163301
Natural History Study of Kaposi Sarcoma
National Cancer Institute (NCI)
NCT06375122
SHARE Program: SUSTAIN
Florida State University
NCT06934395
Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men
University of Chicago
NCT06894199
Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV
University of Maryland, Baltimore
NCT06624839
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Massachusetts General Hospital
NCT05570812
Stress and Pain in People Living With HIV
Yale University
NCT06784908
PrEP Intervention in Prince George's County, Maryland
George Mason University
NCT06141408
Economic Navigation and Strengthening to Research Unrestricted Services for Transgender Women (ENTRUST)
University of Central Florida
NCT06202898
1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV
Johns Hopkins University
NCT05608421
Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use
University of Alabama at Birmingham
NCT06829238
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
Massachusetts General Hospital
NCT07199335
Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
Wake Forest University Health Sciences
NCT05858034
Predictors of Health Service Utilizations Among Key Population in Washington DC
Us Helping Us, People Into Living
NCT06046079
The Use of Leukapheresis to Support HIV Pathogenesis Studies
University of California, San Francisco
NCT01161199
Improving HIV Care Continuum Outcomes Among Formerly Incarcerated Individuals Through Critical Time Legal Interventions
University of Central Florida
NCT06171919
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
Yale University
NCT06513819
TelePrEP for At-risk Youth in Colorado
University of Colorado, Denver
NCT05520905
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
University of California, San Diego
NCT05514899
Improving Physical Ability and Cellular Senescence Elimination in HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07144293
Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama
University of Alabama at Birmingham
NCT05384145
Universal Basic Income and Structural Racism in the US South: HIV Care
University of Arkansas
NCT06186128
Implementation and Deliver of Lenacapavir for PrEP in a Community Pharmacy Setting
Kelley-Ross & Associates
NCT07210125
Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV
Brown University
NCT03862924
A Study to Improve Skeletal Muscle in Veterans With HIV
VA Office of Research and Development
NCT06845046
The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease
Vanderbilt University Medical Center
NCT06113003
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
University of Alabama at Birmingham
NCT05965518
Single Session Narrative Therapy Study
University of Washington
NCT06479980
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
University of Florida
NCT07112001
Inflammation and Depression in People With HIV
Emory University
NCT05849038
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
University of Alabama at Birmingham
NCT07231640
IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas
University of Nebraska
NCT06451341
Expression of Stress Markers During Meth Treatment (EXPRESS+)
University of California, Los Angeles
NCT05558345
Assessing Peer Support for Physical Activity in Women With HIV and Hypertension
University of Alabama at Birmingham
NCT07025109
HIV Suicide Prevention With AI-DBT
Rutgers, The State University of New Jersey
NCT07339189
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
University of California, San Francisco
NCT01202305
Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption
National Cancer Institute (NCI)
NCT05419024
Wellness, Intervention Strategies and HIV Care
University of California, San Francisco
NCT07069374
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
Massachusetts General Hospital
NCT06001814
Patient-provider Decision Aid for HIV Post-exposure Prophylaxis Following Sexual Assault
University of Arkansas
NCT06139354
Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06796686
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Trial Landscape
304 indexed HIV studies · 109 recruiting (36%).
Phase mix: 25 late (III/IV) vs 64 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV?
PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.