Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
HIV: early-phase trial registry
109 of 304 indexed HIV trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #27 of 28,707 conditions by registered trial count.
304 US clinical trials · 109 currently recruiting · #27 of 28,707 conditions by registered trial count
HIV: 304 US clinical trials tracked, 109 recruiting.
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
Enrollment posture brief
Registry condition hiv
OPEN 109 | RECR 36% | LATE 25 | EARLY 64 | RANK #27 | SPON 24
Volume-matched condition peers
Nearest open-share peer: Acute Respiratory Failure (36% recruiting · 14 trials)
HIV lists 109 open slots (36% of 304 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for HIV on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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HIV recruits in line with its size-band peers.
109 of 304 indexed trials (35.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of HIV trials is spread across many organizations.
National Institute of Allergy and Infectious Diseases (NIAID) accounts for 24 of 304 trials (7.9%). 115 distinct sponsors appear on at least one study for this condition label.
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Typical HIV enrolment sits around 100 participants.
Median target enrolment is 100 among the 304 trials that report a genuine target (sentinel values excluded). 142 of those (46.7%) plan for fewer than 100 participants.
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HIV research is mostly interventional.
252 interventional and 52 observational studies make up this index (82.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
304 total, page 2 of 7
Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain
Washington University School of Medicine
NCT07270406
Human Immunodeficiency Virus (HIV) Food Insecurities
Wake Forest University Health Sciences
NCT04943861
Advancing Dignity, Health, and Optimism in Connection With Long Acting Injectables
Mazonson & Santas
NCT05208541
Enhancing Wellness Through Affirming Services and Education
Duke University
NCT05700474
Increasing PrEP With Trans Women in the Deep South
CrescentCare
NCT05689281
Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Johns Hopkins University
NCT06263426
Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV
Butler Hospital
NCT05752500
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
University of Florida
NCT05561595
Case Management Dyad
University of Chicago
NCT06162897
Alcohol Research in HIV: Relapse Prevention
Johns Hopkins University
NCT05163301
Natural History Study of Kaposi Sarcoma
National Cancer Institute (NCI)
NCT06375122
SHARE Program: SUSTAIN
Florida State University
NCT06934395
Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men
University of Chicago
NCT06894199
Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV
University of Maryland, Baltimore
NCT06624839
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Massachusetts General Hospital
NCT05570812
Stress and Pain in People Living With HIV
Yale University
NCT06784908
PrEP Intervention in Prince George's County, Maryland
George Mason University
NCT06141408
Economic Navigation and Strengthening to Research Unrestricted Services for Transgender Women (ENTRUST)
University of Central Florida
NCT06202898
1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV
Johns Hopkins University
NCT05608421
Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use
University of Alabama at Birmingham
NCT06829238
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
Massachusetts General Hospital
NCT07199335
Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
Wake Forest University Health Sciences
NCT05858034
Predictors of Health Service Utilizations Among Key Population in Washington DC
Us Helping Us, People Into Living
NCT06046079
The Use of Leukapheresis to Support HIV Pathogenesis Studies
University of California, San Francisco
NCT01161199
Improving HIV Care Continuum Outcomes Among Formerly Incarcerated Individuals Through Critical Time Legal Interventions
University of Central Florida
NCT06171919
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
Yale University
NCT06513819
TelePrEP for At-risk Youth in Colorado
University of Colorado, Denver
NCT05520905
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
University of California, San Diego
NCT05514899
Improving Physical Ability and Cellular Senescence Elimination in HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07144293
Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama
University of Alabama at Birmingham
NCT05384145
Universal Basic Income and Structural Racism in the US South: HIV Care
University of Arkansas
NCT06186128
Implementation and Deliver of Lenacapavir for PrEP in a Community Pharmacy Setting
Kelley-Ross & Associates
NCT07210125
Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV
Brown University
NCT03862924
A Study to Improve Skeletal Muscle in Veterans With HIV
VA Office of Research and Development
NCT06845046
The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease
Vanderbilt University Medical Center
NCT06113003
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
University of Alabama at Birmingham
NCT05965518
Single Session Narrative Therapy Study
University of Washington
NCT06479980
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
University of Florida
NCT07112001
Inflammation and Depression in People With HIV
Emory University
NCT05849038
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
University of Alabama at Birmingham
NCT07231640
IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas
University of Nebraska
NCT06451341
Expression of Stress Markers During Meth Treatment (EXPRESS+)
University of California, Los Angeles
NCT05558345
Assessing Peer Support for Physical Activity in Women With HIV and Hypertension
University of Alabama at Birmingham
NCT07025109
HIV Suicide Prevention With AI-DBT
Rutgers, The State University of New Jersey
NCT07339189
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
University of California, San Francisco
NCT01202305
Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption
National Cancer Institute (NCI)
NCT05419024
Wellness, Intervention Strategies and HIV Care
University of California, San Francisco
NCT07069374
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
Massachusetts General Hospital
NCT06001814
Patient-provider Decision Aid for HIV Post-exposure Prophylaxis Following Sexual Assault
University of Arkansas
NCT06139354
Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health
National Institute of Allergy and Infectious Diseases (NIAID)
NCT06796686
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Named interventions
Most-linked intervention names on HIV records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on HIV trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this HIV page
304 registered trials, 109 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 109 HIV trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Allergy and Infectious Diseases (NIAID) sponsors the most HIV trials on record, review their full trial history before evaluating a specific study. See National Institute of Allergy and Infectious Diseases (NIAID)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This HIV condition card totals 304 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.