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ClinicalTrials.gov 48 recruiting now official registry

Glioma clinical trials

48 of 88 indexed Glioma trials are currently recruiting.

88 US clinical trials · 48 currently recruiting

Glioma is the subject of 88 registered US clinical trials on ClinicalTrials.gov, 48 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 53 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.

The research picture

Glioma has 88 registered US clinical trials, 48 of them open to new participants right now, about 55% of the total.

48
recruiting participants now
55%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
8
top sponsor: National Cancer Institute (NCI)
Phase 138Phase 215Phase 32Phase 41

Active & Recent Trials

88 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 200 participants

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Eli Lilly and Company

NCT04521686

ACTIVE NOT RECRUITING 135 participants

Multimodal Machine Learning Characterization of Solid Tumors

Ciprian Catana, MD, PhD

NCT04687969

ACTIVE NOT RECRUITING NA 124 participants

Simulation-Based Caregiving Skills Training for Family Members of High Grade Glioma Patients

M.D. Anderson Cancer Center

NCT05511324

ACTIVE NOT RECRUITING Phase 2 120 participants

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

NRG Oncology

NCT03180502

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING 80 participants

Assessing Brain Metabolism Using MRS With Deuterated Glucose

University of California, San Francisco

NCT06594315

ACTIVE NOT RECRUITING Phase 2 62 participants

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

National Cancer Institute (NCI)

NCT03718767

ACTIVE NOT RECRUITING Phase 1 60 participants

Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

Case Comprehensive Cancer Center

NCT03514069

ACTIVE NOT RECRUITING NA 50 participants

Step Count Monitoring as a Measure of Physical Activity in Patients With Newly Diagnosed Glioma Undergoing Radiation Therapy

M.D. Anderson Cancer Center

NCT04186832

ACTIVE NOT RECRUITING Phase 2 45 participants

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

Eli Lilly and Company

NCT06413706

ACTIVE NOT RECRUITING NA 44 participants

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma

University of California, San Francisco

NCT03739372

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 1 42 participants

rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temozolomide

Washington University School of Medicine

NCT03687957

ACTIVE NOT RECRUITING Early Phase 1 36 participants

Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma

Jonsson Comprehensive Cancer Center

NCT05045027

ACTIVE NOT RECRUITING NA 27 participants

Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype

Memorial Sloan Kettering Cancer Center

NCT02658279

ACTIVE NOT RECRUITING Phase 1 18 participants

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

Boehringer Ingelheim

NCT05916313

ACTIVE NOT RECRUITING Phase 1 10 participants

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Seattle Children's Hospital

NCT03500991

ACTIVE NOT RECRUITING Phase 1 1 participants

Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

National Cancer Institute (NCI)

NCT05413304

COMPLETED Phase 1 95 participants

Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation

Institut de Recherches Internationales Servier

NCT02481154

COMPLETED Phase 1 66 participants

A Dose-Escalation Study in Participants With Recurrent Malignant Glioma

Eli Lilly and Company

NCT01682187

COMPLETED Phase 1 59 participants

Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma

Diffusion Pharmaceuticals

NCT01465347

COMPLETED 55 participants

Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors

Wake Forest University Health Sciences

NCT02747407

COMPLETED Phase 2 43 participants

Tamoxifen and Bortezomib to Treat Recurrent Brain Tumors

National Cancer Institute (NCI)

NCT00108069

COMPLETED Phase 2 42 participants

Temozolomide Chronotherapy for High Grade Glioma

Washington University School of Medicine

NCT02781792

COMPLETED Phase 1 31 participants

A Trial of the Protease Inhibitor Nelfinavir and Concurrent Radiation and Temozolomide in Patients With WHO Grade IV Glioma

Abramson Cancer Center at Penn Medicine

NCT01020292

COMPLETED Phase 1 30 participants

A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy

National Cancer Institute (NCI)

NCT00001573

COMPLETED NA 29 participants

Resting-State Functional MRI in Glioma Patients Before and After Surgery

M.D. Anderson Cancer Center

NCT03964909

COMPLETED Phase 1 28 participants

Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

Jennie Taylor

NCT02549833

COMPLETED Phase 2 26 participants

A Study of High-Dose Chemoradiation Using Biologically-Based Target Volume Definition in Patients With Glioblastoma

University of Michigan Rogel Cancer Center

NCT02805179

COMPLETED Phase 1 24 participants

A Study of Xeloda (Capecitabine) Plus Radiation Therapy in Children With Newly Diagnosed Gliomas

Hoffmann-La Roche

NCT00532948

COMPLETED NA 20 participants

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption

InSightec

NCT03551249

COMPLETED Phase 1 18 participants

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors

Emory University

NCT01331135

COMPLETED Phase 1 17 participants

Safety Study of BLZ-100 in Adult Subjects With Glioma Undergoing Surgery

Blaze Bioscience

NCT02234297

COMPLETED Phase 2 15 participants

Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors

Jason J. Luke, MD

NCT04056910

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

COMPLETED Phase 2 7 participants

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT03027388

COMPLETED Phase 1 6 participants

Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors

Washington University School of Medicine

NCT01999270

COMPLETED Phase 1 5 participants

Pharmacokinetics (PK) Study of AC480 for Recurrent Glioma

Annick Desjardins

NCT00979173

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 15
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioma Trial Landscape

88 indexed Glioma studies · 48 recruiting (55%).

Phase mix: 3 late (III/IV) vs 53 early (I/II).

Top sponsor: National Cancer Institute (NCI) (8 trials), 9 others listed. 38 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioma?

PlainTrial tracks 88 US clinical trials for Glioma, of which 48 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.