Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Use: early-phase trial registry
42 of 89 indexed Substance Use trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #154 of 28,707 conditions by registered trial count.
89 US clinical trials · 42 currently recruiting · #154 of 28,707 conditions by registered trial count
Substance Use: 89 US clinical trials tracked, 42 recruiting.
Substance Use is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins Bloomberg School of Public Health, running 6 of these trials.
Enrollment posture brief
Registry condition substance-use
OPEN 42 | RECR 47% | LATE 2 | EARLY 4 | RANK #154 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Crohn Disease (47% recruiting · 72 trials)
Substance Use lists 42 open slots (47% of 89 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Use on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance Use is recruiting above its size-band peers.
42 of 89 indexed trials (47.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Substance Use trials is spread across many organizations.
Johns Hopkins Bloomberg School of Public Health accounts for 6 of 89 trials (6.7%). 56 distinct sponsors appear on at least one study for this condition label.
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Typical Substance Use enrolment sits around 224 participants.
Median target enrolment is 224 among the 89 trials that report a genuine target (sentinel values excluded). 26 of those (29.2%) plan for fewer than 100 participants.
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Substance Use research is mostly interventional.
84 interventional and 5 observational studies make up this index (94.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
89 total, page 1 of 2
Primary Connections for Youth and Families
The National Center on Addiction and Substance Abuse at Columbia University
NCT05964010
M2VA Pain Care Pathway
Yale University
NCT06526143
Parenting in 2 Worlds Multisite Trial
Arizona State University
NCT06324318
An Evaluation of the Pink Cloud Application in Post- Treatment Substance Use Disorder Support
Loyola Marymount University
NCT07042451
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
University of Pittsburgh
NCT05404750
Health and Resilience Projects: Foundations
University of Georgia
NCT05253235
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Wake Forest University Health Sciences
NCT04927143
Culturally Responsive Community Driven Substance Use Recovery for Black and Latinx Population
Yale University
NCT05260047
Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples
Hunter College of City University of New York
NCT06307977
Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)
NYU Langone Health
NCT06116266
J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations
University of Chicago
NCT06477588
Gii'Igoshimong: Sitting With Your First Family
Johns Hopkins Bloomberg School of Public Health
NCT07075081
Women Focused Encounters for Resilience Independence Strength and Eudaimonia
University of California, San Diego
NCT06216600
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
Massachusetts General Hospital
NCT06115746
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
University of Michigan
NCT07094061
The Collaborative Care PrTNER Study
Children's Hospital of Philadelphia
NCT06585631
Journey of Transformation Curriculum for Native American Youth
University of Washington
NCT05731713
A Regional Partnership to Improve Outcomes Through Fatherhood Engagement
Montefiore Medical Center
NCT05562557
Recovery Finance: Financial Health and Mental Health After Incarceration
Yale University
NCT06914856
Teen Health Choices & Wellness
Brown University
NCT06822569
Parent SMART (Substance Misuse in Adolescents in Residential Treatment)
Brown University
NCT05169385
Enhancing Wellness Through Affirming Services and Education
Duke University
NCT05700474
Family Spirit Strengths
Johns Hopkins Bloomberg School of Public Health
NCT05836090
Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)
University of Maryland, Baltimore
NCT06501781
Adverse Adolescent Pathways to Substance Use
University of North Carolina, Chapel Hill
NCT06977178
The Hastiin Bidziil (Strong Man) Intervention
Johns Hopkins Bloomberg School of Public Health
NCT06559774
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use
Oregon Research Institute
NCT06306287
Ketamine for Methamphetamine Use Disorder
University of Texas Southwestern Medical Center
NCT06496750
Substance Use Treatment and Its Role in Supporting Social Cognition
Nova Southeastern University
NCT06535919
Adaptation and Evaluation of Bright Horizons
Johns Hopkins Bloomberg School of Public Health
NCT05743699
ANCHORS Alcohol & Sexual Health Study: UH3 Project
University of Florida
NCT04331704
MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
Medical University of South Carolina
NCT04998916
Native Spirit: Significant Aim 3: Intervention
Arizona State University
NCT06785311
Pre-exposure Prophylaxis (PrEP) Uptake and Adherence Intervention for Women with Trauma-related Conditions
The University of Texas Health Science Center, Houston
NCT06558825
Single Session Narrative Therapy Study
University of Washington
NCT06479980
Pre-exposure Prophylaxis (PrEP) Adherence Intervention for Women with Substance Use Disorders
The University of Texas Health Science Center, Houston
NCT06158607
Cultural Adaptation of Drug Treatment for DJJ Youth
University of California, San Francisco
NCT06003725
CARS: Cannabis and Alcohol Reduction Study
Medical University of South Carolina
NCT05486234
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
NCT06442423
A Novel Intervention for Patients With Cancer
Dana-Farber Cancer Institute
NCT05643027
SmartSteps: A Context-Aware, PrEP Adherence Intervention for Individuals With Substance Use Disorder
Brigham and Women's Hospital
NCT05378399
Supportive Release Center Study
University of Chicago
NCT03616990
Novel Prevention Intervention Program to Reduce Risky Patterns of Substance Use Among Emerging Adults
Rutgers, The State University of New Jersey
NCT06287203
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
Yale University
NCT05286879
Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement
University of Michigan
NCT04850274
Assessing the PrEP Care Cascade Among Black Men and Transwomen in the Southeastern US
University of Connecticut
NCT04832477
Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
Hunter College of City University of New York
NCT05000866
The Substance Abuse Treatment to HIV Care II (SAT2HIV-II) Project
Ohio State University
NCT04687917
FostrSpace-CASA R61/R33
University of California, San Francisco
NCT06875323
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Use records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Use trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Use page
89 registered trials, 42 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 42 Substance Use trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins Bloomberg School of Public Health sponsors the most Substance Use trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins Bloomberg School of Public Health's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Use condition card totals 89 registered trials; most-linked intervention Treatment as Usual; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.