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NCT05773326 · ClinicalTrials.gov registry record · Early Phase 1
Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG
A Early Phase 1 study of Glioblastoma and Glioma, sponsored by Nader Sanai.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT05773326: Recruiting Early Phase 1 study of Glioblastoma and Glioma, sponsored by Nader Sanai.
NCT05773326 is a Early Phase 1 study of Glioblastoma and Glioma that is actively recruiting participants, run by Nader Sanai. The registered enrollment target is 12 participants, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05773326, a Early Phase 1 study of Glioblastoma and Glioma, is actively recruiting participants, sponsored by Nader Sanai.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single-center, open-label, dose-escalating Phase 0 trial that will enroll participants with a confirmed diagnosed recurrent high-grade glioma (grade 3 or 4 per WHO criteria) targeting the mTOR pathway. Eligible participants will be administered a single infusion of temsirolimus through super-selective intra-arterial infusion or intravenous infusion. Participants will receive the study drug administration on the same day as the planned surgical resection of the tumor.
Primary Outcome
Total and unbound temsirolimus concentration in tumor tissue.
Conditions Studied
Interventions
- DRUG Temsirolimus
Study Locations (1)
Arizona
- St. Joseph's Hospital and Medical Center - Phoenix
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2023-05-15 |
| Est. Completion | 2028-05 |
| Phase | Early Phase 1 |
What NCT05773326 shows while recruiting
NCT05773326 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (89% lower).
The record links to 4 conditions, with Glioblastoma appearing as the primary indexed condition, and to 1 intervention - of which Temsirolimus is the first listed.
NCT05773326 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT05773326 about?
NCT05773326 is a clinical study titled "Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG". This is a single-center, open-label, dose-escalating Phase 0 trial that will enroll participants with a confirmed diagnosed recurrent high-grade glioma (grade 3 or 4 per WHO criteria) targeting the mTOR pathway. Eligible participants will be administered a single infusion of temsirolimus through sup...
What is the current status of trial NCT05773326?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 12 participants. The study started on 2023-05-15. Estimated completion is 2028-05.
What conditions does trial NCT05773326 study?
This clinical trial studies the following conditions: Glioblastoma, Glioma, High Grade Glioma, Glioma, Malignant.
What interventions are being tested in trial NCT05773326?
The interventions under investigation include: Temsirolimus (DRUG).
Who is sponsoring clinical trial NCT05773326?
This trial is sponsored by Nader Sanai, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05773326 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05773326's enrollment target sits among peer trials
12 180th of 199 higher than 13 of 199 other Glioblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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