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NCT03728673 · ClinicalTrials.gov registry record · Phase 2
A Study Utilizing Escitalopram in Glioma Patients
A Phase 2 study of Glioma and Glioma of Brain, sponsored by University of Nebraska.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT03728673: Recruiting Phase 2 study of Glioma and Glioma of Brain, sponsored by University of Nebraska.
NCT03728673 is a Phase 2 study of Glioma and Glioma of Brain that is actively recruiting participants, run by University of Nebraska. The registered enrollment target is 20 participants, below the 210-participant average among 87 other Glioma trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03728673, a Phase 2 study of Glioma and Glioma of Brain, is actively recruiting participants, sponsored by University of Nebraska.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Glioma is a cancer of glial cells, a class of tissue supporting neuronal function in the brain. As many as 85% of glioma patients experience cognitive impairment. This is not only from direct tumor involvement, but also from therapy such as cranial radiation and chemotherapy, which degrades neuronal function. There is evidence that serotonin selective reuptake inhibitors (SSRIs), such as escitalopram, improve cognition or prevent cognitive decline and may also improve outcomes critical to overall survival including functional independence, psychosocial stability, and quality of life. This pilot study will evaluate the effectiveness of the selective serotonin reuptake inhibitor (SSRI) escitalopram for treating cognitive impairment in newly diagnosed grade IV glioma over a 17 week treatment period.
Primary Outcome
Changes in cognition will be measured using the NIH Toolbox neurocognitive assessments. The NIH Toolbox has excellent test / re-test reliability across composite domain scores r = .86 - .9263. It has also shown strong convergent (r = .78 - .9) and discriminant (r = .19 - .39) validities. It has been validated on groups of patients with Spinal Cord Injuries, Traumatic Brain Injury and Stroke. More recently a small group of patients diagnosed with diffuse glioma completed the NIH Toolkit Cognitive
Conditions Studied
Interventions
- DRUG Escitalopram Oral Capsules
Study Locations (1)
Nebraska
- University of Nebraska Medical Center - Omaha
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2019-03-06 |
| Est. Completion | 2027-08 |
| Phase | Phase 2 |
What NCT03728673 shows while recruiting
NCT03728673 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 210-participant average among 87 other Glioma trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Glioma appearing as the primary indexed condition, and to 1 intervention - of which Escitalopram Oral Capsules is the first listed.
NCT03728673 reports a single indexed study location in Nebraska.
Frequently Asked Questions
What is clinical trial NCT03728673 about?
NCT03728673 is a clinical study titled "A Study Utilizing Escitalopram in Glioma Patients". Glioma is a cancer of glial cells, a class of tissue supporting neuronal function in the brain. As many as 85% of glioma patients experience cognitive impairment. This is not only from direct tumor involvement, but also from therapy such as cranial radiation and chemotherapy, which degrades neuronal...
What is the current status of trial NCT03728673?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2019-03-06. Estimated completion is 2027-08.
What conditions does trial NCT03728673 study?
This clinical trial studies the following conditions: Glioma, Glioma of Brain.
What interventions are being tested in trial NCT03728673?
The interventions under investigation include: Escitalopram Oral Capsules (DRUG).
Who is sponsoring clinical trial NCT03728673?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03728673 being conducted?
This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glioma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03728673's enrollment target sits among peer trials
20 65th of 87 higher than 18 of 87 other Glioma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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