Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Glioblastoma Multiforme

Open-data reference.

89 US clinical trials · 37 currently recruiting

Active & Recent Trials

RECRUITING 1,015 participants

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

Jasper Gerritsen

NCT06146738

RECRUITING 564 participants

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

Jasper Gerritsen

NCT06146725

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING 464 participants

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Jasper Gerritsen

NCT06283927

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING 350 participants

Targeted Pediatric High-Grade Glioma Therapy

Nationwide Children's Hospital

NCT05839379

RECRUITING 200 participants

Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT00083512

RECRUITING Phase 2 190 participants

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Baptist Health South Florida

NCT06991101

RECRUITING Phase 2 170 participants

A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

Cedars-Sinai Medical Center

NCT05708352

RECRUITING Phase 2 120 participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Nationwide Children's Hospital

NCT05843253

RECRUITING 120 participants

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

Baptist Health South Florida

NCT05756985

RECRUITING 100 participants

Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning

Washington University School of Medicine

NCT05864976

RECRUITING Phase 1 98 participants

Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects

VBI Vaccines

NCT03382977

RECRUITING Phase 1 66 participants

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Orbus Therapeutics

NCT05879367

RECRUITING Phase 1 62 participants

HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

David Baskin MD

NCT03596086

RECRUITING Phase 1 54 participants

Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA

Northwell Health

NCT01269853

RECRUITING Phase 1 50 participants

Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells

Jonsson Comprehensive Cancer Center

NCT06059690

RECRUITING Phase 1 50 participants

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05083754

RECRUITING Phase 1 49 participants

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

Neonc Technologies

NCT02704858

RECRUITING NA 40 participants

Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

Washington University School of Medicine

NCT05281731

RECRUITING Phase 1 36 participants

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

UNC Lineberger Comprehensive Cancer Center

NCT05366179

RECRUITING Phase 1 36 participants

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

Boston Scientific Corporation

NCT05303467

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Phase 1 30 participants

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

University of Arizona

NCT06814496

RECRUITING Phase 1 30 participants

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

Aveta Biomics

NCT06011109

RECRUITING 30 participants

Loupe-Based Intraoperative Fluorescence Imaging

Guoqiang Yu

NCT04780009

RECRUITING Phase 1 28 participants

Study of Pembrolizumab and M032 (NSC 733972)

University of Alabama at Birmingham

NCT05084430

RECRUITING Phase 2 25 participants

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Northwestern University

NCT05864534

RECRUITING Phase 1 24 participants

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

M.D. Anderson Cancer Center

NCT03911388

RECRUITING Phase 1 20 participants

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

University of Miami

NCT05956821

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 2 16 participants

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

Leland Metheny

NCT05052957

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

RECRUITING Early Phase 1 12 participants

Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme

Stony Brook University

NCT05423210

RECRUITING Phase 1 11 participants

Sonodynamic Therapy in Patients With Recurrent GBM

Shayan Moosa, MD

NCT06039709

RECRUITING Phase 1 10 participants

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Chirag G. Patil

NCT04977375

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

ACTIVE NOT RECRUITING NA 981 participants

Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM

NovoCure

NCT04471844

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 2 103 participants

Nivolumab and Temozolomide Versus Temozolomide Alone in Newly Diagnosed Elderly Patients With GBM

University of Sydney

NCT04195139

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING Phase 2 90 participants

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

Bryan Allen

NCT02344355

ACTIVE NOT RECRUITING Phase 2 87 participants

A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

NuvOx

NCT03862430

ACTIVE NOT RECRUITING Phase 1 63 participants

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Patrick Wen, MD

NCT04606316

ACTIVE NOT RECRUITING Phase 2 60 participants

Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02177578

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Phase 1 52 participants

A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

Katmai Pharmaceuticals

NCT05222802

ACTIVE NOT RECRUITING Phase 2 50 participants

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

BPGbio

NCT04752813

ACTIVE NOT RECRUITING Early Phase 1 48 participants

Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients

Nader Sanai

NCT02933736

ACTIVE NOT RECRUITING Early Phase 1 45 participants

Study of Pamiparib in Newly Diagnosed and rGBM

Nader Sanai

NCT04614909

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 2 40 participants

Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)

University of Florida

NCT05120284

ACTIVE NOT RECRUITING Early Phase 1 39 participants

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

Sumitomo Pharma America

NCT05023551

ACTIVE NOT RECRUITING Phase 1 39 participants

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

University of Florida

NCT05353530

ACTIVE NOT RECRUITING Phase 1 35 participants

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Children's Oncology Group

NCT04978727

ACTIVE NOT RECRUITING Phase 1 32 participants

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Pediatric Brain Tumor Consortium

NCT03389802

ACTIVE NOT RECRUITING Phase 1 24 participants

A Phase 1b/2, Multicenter, Open-label Study of ACP-196 in Subjects With Recurrent Glioblastoma Multiforme (GBM)

Acerta Pharma

NCT02586857

ACTIVE NOT RECRUITING Phase 1 17 participants

A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma

Bryan Allen

NCT04900792

ACTIVE NOT RECRUITING Phase 1 16 participants

Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma

Oblato

NCT05561374

ACTIVE NOT RECRUITING Phase 1 16 participants

Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03961971

ACTIVE NOT RECRUITING NA 12 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Northwell Health

NCT03630289

ACTIVE NOT RECRUITING 2 participants

Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients

AdventHealth Translational Research Institute

NCT06054529

COMPLETED Phase 1 226 participants

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Celgene

NCT01177397

COMPLETED Phase 2 112 participants

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

National Cancer Institute (NCI)

NCT00995007

COMPLETED Phase 1 88 participants

Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme

SCRI Development Innovations

NCT01349660

COMPLETED Phase 2 81 participants

Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)

EMD Serono

NCT00093964

COMPLETED Phase 2 75 participants

6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients

M.D. Anderson Cancer Center

NCT00504660

COMPLETED Phase 2 67 participants

Ph. II Temozolomide + O6-BG in Treatment of Pts w Temozolomide-Resistant Malignant Glioma

Duke University

NCT00613093

COMPLETED Phase 2 63 participants

PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation

Brown University

NCT01402063

COMPLETED Phase 2 58 participants

PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma

Massachusetts General Hospital

NCT01112527

COMPLETED Phase 2 56 participants

Phase 2 Study MPC-6827 for Recurrent Glioblastoma Multiforme

Myrexis

NCT00892931

COMPLETED Phase 2 42 participants

Temozolomide Chronotherapy for High Grade Glioma

Washington University School of Medicine

NCT02781792

COMPLETED Phase 2 41 participants

Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Katy Peters

NCT00979017

COMPLETED Phase 2 41 participants

Dose Confirmation Study of Cotara for the Treatment of Glioblastoma Multiforme at First Relapse

Peregrine Pharmaceuticals

NCT00677716

COMPLETED Phase 1 40 participants

A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma

Alaunos Therapeutics

NCT02026271

COMPLETED Phase 1 37 participants

A Dose Per Fraction Escalation Trial of Hypofractionated IMRT With Temozolomide for Newly Diagnosed Glioblastoma

University of Colorado, Denver

NCT00792012

COMPLETED Phase 1 36 participants

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Julie Krystal

NCT01837862

COMPLETED Phase 2 36 participants

AMG 102 and Avastin for Recurrent Malignant Glioma

Katy Peters

NCT01113398

COMPLETED Phase 1 35 participants

Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Washington University School of Medicine

NCT02715609

COMPLETED Phase 1 32 participants

AMG 595 First-in-Human in Recurrent Gliomas

Amgen

NCT01475006

COMPLETED Phase 2 22 participants

A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma

Tracon Pharmaceuticals

NCT01564914

COMPLETED Phase 1 22 participants

AZD8055 for Adults With Recurrent Gliomas

National Cancer Institute (NCI)

NCT01316809

COMPLETED Phase 1 12 participants

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Biogen

NCT00031083

COMPLETED Phase 1 11 participants

Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma

Northwell Health

NCT00301418

COMPLETED Phase 1 10 participants

Monteris AutoLITT™ FIM Safety Trial for Recurrent/Progressive Brain Tumors

Monteris Medical

NCT00747253

COMPLETED Phase 1 10 participants

Cellular Immunotherapy Study for Brain Cancer

Jonsson Comprehensive Cancer Center

NCT01144247

COMPLETED Phase 1 9 participants

Cancer Stem Cell High-Throughput Drug Screening Study

Swedish Medical Center

NCT02654964

COMPLETED Phase 2 9 participants

GW572016 to Treat Recurrent Malignant Brain Tumors

National Cancer Institute (NCI)

NCT00107003

COMPLETED Phase 2 7 participants

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT03027388

Phase Distribution

PhaseTrial count
Early Phase 1 48
Phase 2 26
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Multiforme Trial Landscape

ClinicalTrials.gov lists 89 US studies indexed under Glioblastoma Multiforme, and 37 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Glioblastoma Multiforme shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 74 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Glioblastoma Multiforme is led by Northwell Health with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 89 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma Multiforme?

PlainTrial tracks 89 US clinical trials for Glioblastoma Multiforme, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma Multiforme?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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