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ClinicalTrials.gov 37 recruiting now official registry

Glioblastoma Multiforme clinical trials

37 of 89 indexed Glioblastoma Multiforme trials are currently recruiting.

89 US clinical trials · 37 currently recruiting

Glioblastoma Multiforme is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Northwell Health, running 6 of these trials.

The research picture

Glioblastoma Multiforme has 89 registered US clinical trials, 37 of them open to new participants right now, about 42% of the total.

37
recruiting participants now
42%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
6
top sponsor: Northwell Health
Phase 148Phase 226Phase 31

Active & Recent Trials

89 total, page 1 of 2

RECRUITING 1,015 participants

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

Jasper Gerritsen

NCT06146738

RECRUITING 564 participants

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

Jasper Gerritsen

NCT06146725

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING 464 participants

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Jasper Gerritsen

NCT06283927

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING 350 participants

Targeted Pediatric High-Grade Glioma Therapy

Nationwide Children's Hospital

NCT05839379

RECRUITING 200 participants

Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT00083512

RECRUITING Phase 2 190 participants

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Baptist Health South Florida

NCT06991101

RECRUITING Phase 2 170 participants

A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

Cedars-Sinai Medical Center

NCT05708352

RECRUITING Phase 2 120 participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Nationwide Children's Hospital

NCT05843253

RECRUITING 120 participants

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

Baptist Health South Florida

NCT05756985

RECRUITING 100 participants

Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning

Washington University School of Medicine

NCT05864976

RECRUITING Phase 1 98 participants

Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects

VBI Vaccines

NCT03382977

RECRUITING Phase 1 66 participants

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Orbus Therapeutics

NCT05879367

RECRUITING Phase 1 62 participants

HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM

David Baskin MD

NCT03596086

RECRUITING Phase 1 54 participants

Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA

Northwell Health

NCT01269853

RECRUITING Phase 1 50 participants

Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells

Jonsson Comprehensive Cancer Center

NCT06059690

RECRUITING Phase 1 50 participants

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05083754

RECRUITING Phase 1 49 participants

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

Neonc Technologies

NCT02704858

RECRUITING NA 40 participants

Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

Washington University School of Medicine

NCT05281731

RECRUITING Phase 1 36 participants

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

UNC Lineberger Comprehensive Cancer Center

NCT05366179

RECRUITING Phase 1 36 participants

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

Boston Scientific Corporation

NCT05303467

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Phase 1 30 participants

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

University of Arizona

NCT06814496

RECRUITING Phase 1 30 participants

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

Aveta Biomics

NCT06011109

RECRUITING 30 participants

Loupe-Based Intraoperative Fluorescence Imaging

Guoqiang Yu

NCT04780009

RECRUITING Phase 1 28 participants

Study of Pembrolizumab and M032 (NSC 733972)

University of Alabama at Birmingham

NCT05084430

RECRUITING Phase 2 25 participants

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Northwestern University

NCT05864534

RECRUITING Phase 1 24 participants

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

M.D. Anderson Cancer Center

NCT03911388

RECRUITING Phase 1 20 participants

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

University of Miami

NCT05956821

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 2 16 participants

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

Leland Metheny

NCT05052957

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

RECRUITING Early Phase 1 12 participants

Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme

Stony Brook University

NCT05423210

RECRUITING Phase 1 11 participants

Sonodynamic Therapy in Patients With Recurrent GBM

Shayan Moosa, MD

NCT06039709

RECRUITING Phase 1 10 participants

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Chirag G. Patil

NCT04977375

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

ACTIVE NOT RECRUITING NA 981 participants

Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM

NovoCure

NCT04471844

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 2 103 participants

Nivolumab and Temozolomide Versus Temozolomide Alone in Newly Diagnosed Elderly Patients With GBM

University of Sydney

NCT04195139

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING Phase 2 90 participants

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

Bryan Allen

NCT02344355

ACTIVE NOT RECRUITING Phase 2 87 participants

A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

NuvOx

NCT03862430

ACTIVE NOT RECRUITING Phase 1 63 participants

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Patrick Wen, MD

NCT04606316

ACTIVE NOT RECRUITING Phase 2 60 participants

Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02177578

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Phase 1 52 participants

A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)

Katmai Pharmaceuticals

NCT05222802

ACTIVE NOT RECRUITING Phase 2 50 participants

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

BPGbio

NCT04752813

ACTIVE NOT RECRUITING Early Phase 1 48 participants

Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients

Nader Sanai

NCT02933736

ACTIVE NOT RECRUITING Early Phase 1 45 participants

Study of Pamiparib in Newly Diagnosed and rGBM

Nader Sanai

NCT04614909

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Phase Distribution

PhaseTrial count
Phase 1 48
Phase 2 26
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Multiforme Trial Landscape

89 indexed Glioblastoma Multiforme studies · 37 recruiting (42%).

Phase mix: 1 late (III/IV) vs 74 early (I/II).

Top sponsor: Northwell Health (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma Multiforme?

PlainTrial tracks 89 US clinical trials for Glioblastoma Multiforme, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma Multiforme?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.