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NCT06101069 · ClinicalTrials.gov registry record · NA
Development of MRF for Characterization of Brain Tumors After Radiotherapy
A NA study of Glioma and Brain Tumor, sponsored by Case Comprehensive Cancer Center.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 2
- Study locations
NCT06101069: Recruiting NA study of Glioma and Brain Tumor, sponsored by Case Comprehensive Cancer Center.
NCT06101069 is a NA study of Glioma and Brain Tumor that is actively recruiting participants, run by Case Comprehensive Cancer Center. The registered enrollment target is 60 participants, below the 209-participant average among 87 other Glioma trials with a reported enrollment target (71% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06101069, a NA study of Glioma and Brain Tumor, is actively recruiting participants, sponsored by Case Comprehensive Cancer Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short scan time of 5 min for viewing the entire brain. This is an advanced quantitative assessment of brain tissues. This method is being applied with IVIM MRI to be able to tell the difference between a brain with radiation necrosis and a brain with tumor recurrence. Participants will consist of individuals who have received radiation therapy in the past and were diagnosed with radiation necrosis, individuals with recurrent tumors, individuals with previously untreated tumors, and healthy individuals who have no brain diseases and have not had radiation treatment to the brain. Participants will undergo an MRI scan at a one-time research study visit; no extra tests or procedures will be required for this research study. The primary objectives of this study are: * To demonstrate the clinical feasibility of combining MRF with state-of-the-art parallel imaging techniques to achieve high-resolution quantitative imaging within a reasonable scan time of 5 min for whole brain coverage. * To apply the developed quantitative approach in combination with IVIM MRI for differentiation of tumor recurrence and radiation necrosis. * To investigate the effect of radiation dose on the development of radiation necrosis and tumor recurrence.
Primary Outcome
The primary objective is to use MRF and IVIM MRI to demonstrate clinical feasibility and differentiation of tumor recurrence and radiation necrosis. This will be measured by the 3D-MRF T1 relaxation times. The difference in mean T1 between each cohort of participants will be measured.
Conditions Studied
Interventions
- PROCEDURE MRF in conjunction with IVIM MRI without contrast
Study Locations (2)
Ohio
- University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center - Cleveland
- Cleveland Clinic Taussig Cancer Center - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-10-14 |
| Est. Completion | 2026-09 |
| Phase | NA |
What NCT06101069 shows while recruiting
NCT06101069 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 209-participant average among 87 other Glioma trials with a reported enrollment target (71% lower).
The record links to 4 conditions, with Glioma appearing as the primary indexed condition, and to 1 intervention - of which MRF in conjunction with IVIM MRI without contrast is the first listed.
NCT06101069 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06101069 about?
NCT06101069 is a clinical study titled "Development of MRF for Characterization of Brain Tumors After Radiotherapy". The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short scan time of 5 min for viewing the entire brain. This is an advanced quan...
What is the current status of trial NCT06101069?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-10-14. Estimated completion is 2026-09.
What conditions does trial NCT06101069 study?
This clinical trial studies the following conditions: Glioma, Brain Tumor, Brain Metastases, Brain Necrosis.
What interventions are being tested in trial NCT06101069?
The interventions under investigation include: MRF in conjunction with IVIM MRI without contrast (PROCEDURE).
Who is sponsoring clinical trial NCT06101069?
This trial is sponsored by Case Comprehensive Cancer Center, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06101069 being conducted?
This trial has 2 study locations across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06101069's enrollment target sits among peer trials
60 30th of 87 higher than 57 of 87 other Glioma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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