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Epilepsy clinical trials
78 of 164 indexed Epilepsy trials are currently recruiting.
164 US clinical trials · 78 currently recruiting
Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.
The research picture
Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.
- 78
- recruiting participants now
- 48%
- of trials open to enrollment
- 21
- in Phase 3–4 (later-stage)
- 9
- top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Active & Recent Trials
164 total, page 1 of 4
Epilepsy Learning Healthcare System (ELHS)
Epilepsy Foundation of America
NCT06265103
De-identified UNMH EEG Corpus Database Creation With Fully De-identified Clinical Information
University of New Mexi
NCT05140265
Genetics of Epilepsy and Related Disorders
Boston Children's Hospital
NCT01858285
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
Human Epilepsy Genetics--Neuronal Migration Disorders Study
Harvard University Faculty of Medicine
NCT00041600
Investigating Epilepsy: Screening and Evaluation
National Institute of Neurological Disorders and Stroke (NINDS)
NCT03478852
Patterns of Neurodevelopmental Disorders
Richard Frye
NCT06213090
Registry and Natural History of Epilepsy-Dyskinesia Syndromes
Boston Children's Hospital
NCT06967727
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02107989
Genetic Markers of Cardiovascular Disease in Epilepsy
Mayo Clinic
NCT02824822
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
Boston Children's Hospital
NCT06585605
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
Southwest Autism Research & Resource Center
NCT04322734
Carbon Dioxide (CO2) Chemosensitivity and SUDEP
University of Iowa
NCT04134754
Surgery as a Treatment for Medically Intractable Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01273129
Localizing Epileptic Networks Using MRI and iEEG
University of Pennsylvania
NCT04649008
Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
VA Office of Research and Development
NCT04419272
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
Epiminder America
NCT07110454
Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
Baylor College of Medicine
NCT05283811
AI-Based Mobile Intervention on Medication Non-Adherence and Transition
University of Central Florida
NCT07445074
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
Neuroelectrics Corporation
NCT04770337
Human Intracranial Electrophysiology
Dartmouth-Hitchcock Medical Center
NCT05529264
Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy)
Kayela Arrotta
NCT05954182
MEHMO Natural History and Biomarkers
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT06019182
Research Evaluating Vagal Excitation AND Anatomical Links
University of Minnesota
NCT06143293
Telephone-Based Support Programs for People With Epilepsy
NYU Langone Health
NCT05082181
Tumor Related Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02639325
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
University of Missouri-Columbia
NCT07329257
Sleep Spindles and Memory in Rolandic Epilepsy
Massachusetts General Hospital
NCT04569708
Amygdala Memory Enhancement
Washington University School of Medicine
NCT05065450
Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
CREmedical
NCT05944692
ESIS in Pediatric DRE
Sarah Katie Ihnen
NCT05469373
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Baylor College of Medicine
NCT05418894
Functional Brain Mapping for Patients with Epilepsy
Wayne State University
NCT05755919
Mapping of Human Cognition
The University of Texas Health Science Center, Houston
NCT05989893
Subcortical Arousal in Perceptual Awareness
Yale University
NCT06934356
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam
NCT07051629
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
UCB Biopharma SRL
NCT04715646
Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.
Epitel
NCT06027749
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
Darcy Krueger
NCT05104983
Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery
Kayela Arrotta
NCT05992402
Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding
University of Pittsburgh
NCT05450978
Implementation and Cost Evaluation of Project UPLIFT
Emory University
NCT06865820
A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy
Praxis Precision Medicines
NCT05737784
Collaborative Care for Anxiety and Depression in Epilepsy
Wake Forest University Health Sciences
NCT05559749
Microelectrode Recordings From the Vagus Nerve in Awake Humans
University of Minnesota
NCT06016686
Pharmacological Modulation of Brain Oscillations in Memory Processing
University of Texas Southwestern Medical Center
NCT05594017
Intracranial Investigation of Neural Circuity Underlying Human Mood
Baylor College of Medicine
NCT05871372
Hippocampal Oscillations During Exploration
NYU Langone Health
NCT07224191
Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings
University of Utah
NCT06883981
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Stanford University
NCT05996900
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 23 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Epilepsy Trial Landscape
164 indexed Epilepsy studies · 78 recruiting (48%).
Phase mix: 21 late (III/IV) vs 39 early (I/II).
Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Epilepsy?
PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Epilepsy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.