Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings

Study Summary

The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, eye tracking) synchronized with invasive neural recordings. Researchers will analyze these multimodal data streams to develop new analytic approaches for studying memory formation in naturalistic settings, with the long-term goal of informing neuromodulation-based memory enhancement treatments for individuals with memory disorders.

Primary Outcome

iEEG power in the theta band between 4-8 Hz, will be assessed to identify the real-world experience features that contribute to changes in this important neural power band for memory encoding.

Conditions Studied

Interventions

• BEHAVIORAL Free and Cued Recall Memory. Temporal Sequence and Spatial Memory

Study Locations (1)