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ClinicalTrials.gov 78 recruiting now official registry

Epilepsy clinical trials

78 of 164 indexed Epilepsy trials are currently recruiting.

164 US clinical trials · 78 currently recruiting

Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.

The research picture

Epilepsy has 164 registered US clinical trials, 78 of them open to new participants right now, about 48% of the total.

78
recruiting participants now
48%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
9
top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Phase 123Phase 216Phase 314Phase 47

Active & Recent Trials

164 total, page 2 of 4

RECRUITING NA 40 participants

Prediction of Anxiety and Memory State

Columbia University

NCT06551090

RECRUITING NA 40 participants

Ear-Seizure Detection (EarSD) Study

Felicia Chu

NCT06598189

RECRUITING NA 40 participants

Computational Neuroscience of Language Processing in the Human Brain

Massachusetts General Hospital

NCT05222594

RECRUITING Phase 1 40 participants

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02531880

RECRUITING Early Phase 1 40 participants

Effect of Rose Odor Exposure on Ictal Apnea

Vanderbilt University Medical Center

NCT07116421

RECRUITING NA 40 participants

A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures

University of Colorado, Denver

NCT04515316

RECRUITING Phase 4 30 participants

Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care

University Hospitals Cleveland Medical Center

NCT06346262

RECRUITING 30 participants

PET/MRI/EEG Imaging Study in Epilepsy

Massachusetts General Hospital

NCT06974305

RECRUITING Phase 2 30 participants

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

Rapport Therapeutics

NCT07219407

RECRUITING NA 30 participants

VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

University of Louisville

NCT03953768

RECRUITING NA 30 participants

Invasive Brain-Computer Interfaces for Attention

University of Texas at Austin

NCT06940089

RECRUITING NA 30 participants

Stimulation-Induced Changes in Fronto-Limbic Network

University of Alabama at Birmingham

NCT05854160

RECRUITING NA 30 participants

Intracranial Stimulation Mapping In Epilepsy

University of Minnesota

NCT05290610

RECRUITING Phase 3 26 participants

Lemborexant Treatment of Insomnia Linked to Epilepsy

University of Manitoba

NCT06262594

RECRUITING NA 24 participants

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

Dartmouth-Hitchcock Medical Center

NCT06425029

RECRUITING NA 24 participants

Effects of Social Feedback on Intracranial EEG

Trustees of Dartmouth College

NCT06975800

RECRUITING 21 participants

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome

Royal Devon and Exeter NHS Foundation Trust

NCT05751525

RECRUITING 20 participants

Brain Metabolism Observed at 7 Tesla

University of Texas Southwestern Medical Center

NCT05085704

RECRUITING Phase 1 20 participants

Understanding Ketamine's Dissociative Effects (KD Study)

Stanford University

NCT04861051

RECRUITING NA 16 participants

Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder

The University of Texas Health Science Center, Houston

NCT06695767

RECRUITING NA 16 participants

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Mayo Clinic

NCT06038929

RECRUITING NA 15 participants

SeizEAR Safety Study

Icahn School of Medicine at Mount Sinai

NCT07088835

RECRUITING NA 10 participants

Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients with Acupuncture Treatment

The University of Texas Health Science Center, Houston

NCT04677751

RECRUITING NA 10 participants

Behavioral and Neuronal Correlates of Human Mood States

Stanford University

NCT06159595

RECRUITING NA 10 participants

Effects of Recorded Music on Clinical and EEG Seizure Activity

Johns Hopkins University

NCT05289934

RECRUITING Phase 1 8 participants

Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042

NeuroPro Therapeutics

NCT07222878

RECRUITING Phase 1 8 participants

A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

NaviFUS Corporation

NCT06388707

RECRUITING Early Phase 1 5 participants

Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery

Sanjeet S. Grewal

NCT06280092

ACTIVE NOT RECRUITING 375 participants

RNS® System Epilepsy Post-Approval Study

NeuroPace

NCT02403843

ACTIVE NOT RECRUITING 300 participants

Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy

University of California, San Francisco

NCT05361070

ACTIVE NOT RECRUITING NA 140 participants

Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)

MedtronicNeuro

NCT03900468

ACTIVE NOT RECRUITING 105 participants

Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy

Johns Hopkins University

NCT02694094

ACTIVE NOT RECRUITING Phase 3 100 participants

RNS System NAUTILUS Study

NeuroPace

NCT05147571

ACTIVE NOT RECRUITING 39 participants

Neural Circulatory Control and SUDEP Risk.

Mayo Clinic

NCT02813980

ACTIVE NOT RECRUITING NA 36 participants

Acoustic Stimulation for Seizure Suppression

NYU Langone Health

NCT03198494

ACTIVE NOT RECRUITING Phase 2 24 participants

RNS System LGS Feasibility Study

NeuroPace

NCT05339126

ACTIVE NOT RECRUITING 20 participants

Neuroliten MVP System Clinical Observation Study

Enliten AI

NCT05520476

ACTIVE NOT RECRUITING NA 12 participants

Acute Recording of Stereotyped High-Frequency Oscillations

Mayo Clinic

NCT05439655

ACTIVE NOT RECRUITING NA 5 participants

Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

Mayo Clinic

NCT03946618

ACTIVE NOT RECRUITING Phase 1 5 participants

BHV-7000 Responsive Neurostimulation System (RNS) Study

Yale University

NCT07125261

COMPLETED Phase 3 767 participants

Brivaracetam Safety and Efficacy Follow-up Study in Subjects With Epilepsy

UCB Biosciences

NCT01339559

COMPLETED 565 participants

Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)

Stanford University

NCT01730170

COMPLETED Phase 3 453 participants

Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study

Children's Hospital Medical Center, Cincinnati

NCT00088452

COMPLETED Phase 3 426 participants

Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures

UCB Biosciences

NCT00520741

COMPLETED Phase 3 356 participants

Rufinamide Given as Adjunctive Therapy in Participants With Refractory Partial Seizures

Eisai

NCT00334958

COMPLETED 303 participants

Brain Blood Flow Studies of Language and Memory

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001288

COMPLETED NA 268 participants

Epilepsy Adherence in Children and Technology (eACT)

Children's Hospital Medical Center, Cincinnati

NCT03817229

COMPLETED Phase 3 249 participants

Study to Evaluate the Safety and Effectiveness of USL255 in Patients With Refractory Partial-onset Seizures

Upsher-Smith Laboratories

NCT01142193

COMPLETED Phase 3 238 participants

Clobazam in Patients With Lennox-Gastaut Syndrome

Lundbeck

NCT00518713

COMPLETED Phase 1 209 participants

Bioequivalence and Food Effect of 250mg of Lamotrigine XR

GlaxoSmithKline

NCT00605371

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Phase Distribution

PhaseTrial count
Phase 1 23
Phase 2 16
Phase 3 14
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Epilepsy Trial Landscape

164 indexed Epilepsy studies · 78 recruiting (48%).

Phase mix: 21 late (III/IV) vs 39 early (I/II).

Top sponsor: National Institute of Neurological Disorders and Stroke (NINDS) (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Epilepsy?

PlainTrial tracks 164 US clinical trials for Epilepsy, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Epilepsy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.