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Epilepsy: early-phase trial registry
78 of 164 indexed Epilepsy trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #65 of 28,707 conditions by registered trial count.
164 US clinical trials · 78 currently recruiting · #65 of 28,707 conditions by registered trial count
Epilepsy: 164 US clinical trials tracked, 78 recruiting.
Epilepsy is the subject of 164 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 39 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Neurological Disorders and Stroke (NINDS), running 9 of these trials.
Enrollment posture brief
Registry condition epilepsy
OPEN 78 | RECR 48% | LATE 21 | EARLY 39 | RANK #65 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Microbial Colonization (48% recruiting · 21 trials)
Epilepsy lists 78 open slots (48% of 164 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Epilepsy on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Epilepsy is recruiting above its size-band peers.
78 of 164 indexed trials (47.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Epilepsy trials is spread across many organizations.
National Institute of Neurological Disorders and Stroke (NINDS) accounts for 9 of 164 trials (5.5%). 95 distinct sponsors appear on at least one study for this condition label.
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Most Epilepsy trials plan to enrol fewer than 100 people.
Median target enrolment is 60 among the 161 trials that report a genuine target (sentinel values excluded). 103 of those (64%) plan for fewer than 100 participants.
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Epilepsy research is mostly interventional.
120 interventional and 44 observational studies make up this index (73.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
164 total, page 2 of 4
Prediction of Anxiety and Memory State
Columbia University
NCT06551090
Ear-Seizure Detection (EarSD) Study
Felicia Chu
NCT06598189
Computational Neuroscience of Language Processing in the Human Brain
Massachusetts General Hospital
NCT05222594
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02531880
Effect of Rose Odor Exposure on Ictal Apnea
Vanderbilt University Medical Center
NCT07116421
A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
University of Colorado, Denver
NCT04515316
Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care
University Hospitals Cleveland Medical Center
NCT06346262
PET/MRI/EEG Imaging Study in Epilepsy
Massachusetts General Hospital
NCT06974305
A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
Rapport Therapeutics
NCT07219407
VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems
University of Louisville
NCT03953768
Invasive Brain-Computer Interfaces for Attention
University of Texas at Austin
NCT06940089
Stimulation-Induced Changes in Fronto-Limbic Network
University of Alabama at Birmingham
NCT05854160
Intracranial Stimulation Mapping In Epilepsy
University of Minnesota
NCT05290610
Lemborexant Treatment of Insomnia Linked to Epilepsy
University of Manitoba
NCT06262594
Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application
Dartmouth-Hitchcock Medical Center
NCT06425029
Effects of Social Feedback on Intracranial EEG
Trustees of Dartmouth College
NCT06975800
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome
Royal Devon and Exeter NHS Foundation Trust
NCT05751525
Brain Metabolism Observed at 7 Tesla
University of Texas Southwestern Medical Center
NCT05085704
Understanding Ketamine's Dissociative Effects (KD Study)
Stanford University
NCT04861051
Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
The University of Texas Health Science Center, Houston
NCT06695767
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Mayo Clinic
NCT06038929
SeizEAR Safety Study
Icahn School of Medicine at Mount Sinai
NCT07088835
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients with Acupuncture Treatment
The University of Texas Health Science Center, Houston
NCT04677751
Behavioral and Neuronal Correlates of Human Mood States
Stanford University
NCT06159595
Effects of Recorded Music on Clinical and EEG Seizure Activity
Johns Hopkins University
NCT05289934
Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042
NeuroPro Therapeutics
NCT07222878
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
NaviFUS Corporation
NCT06388707
Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery
Sanjeet S. Grewal
NCT06280092
RNS® System Epilepsy Post-Approval Study
NeuroPace
NCT02403843
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
University of California, San Francisco
NCT05361070
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
MedtronicNeuro
NCT03900468
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Johns Hopkins University
NCT02694094
RNS System NAUTILUS Study
NeuroPace
NCT05147571
Neural Circulatory Control and SUDEP Risk.
Mayo Clinic
NCT02813980
Acoustic Stimulation for Seizure Suppression
NYU Langone Health
NCT03198494
RNS System LGS Feasibility Study
NeuroPace
NCT05339126
Neuroliten MVP System Clinical Observation Study
Enliten AI
NCT05520476
Acute Recording of Stereotyped High-Frequency Oscillations
Mayo Clinic
NCT05439655
Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy
Mayo Clinic
NCT03946618
BHV-7000 Responsive Neurostimulation System (RNS) Study
Yale University
NCT07125261
Brivaracetam Safety and Efficacy Follow-up Study in Subjects With Epilepsy
UCB Biosciences
NCT01339559
Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)
Stanford University
NCT01730170
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study
Children's Hospital Medical Center, Cincinnati
NCT00088452
Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures
UCB Biosciences
NCT00520741
Rufinamide Given as Adjunctive Therapy in Participants With Refractory Partial Seizures
Eisai
NCT00334958
Brain Blood Flow Studies of Language and Memory
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001288
Epilepsy Adherence in Children and Technology (eACT)
Children's Hospital Medical Center, Cincinnati
NCT03817229
Study to Evaluate the Safety and Effectiveness of USL255 in Patients With Refractory Partial-onset Seizures
Upsher-Smith Laboratories
NCT01142193
Clobazam in Patients With Lennox-Gastaut Syndrome
Lundbeck
NCT00518713
Bioequivalence and Food Effect of 250mg of Lamotrigine XR
GlaxoSmithKline
NCT00605371
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 23 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Epilepsy records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Epilepsy trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Epilepsy page
164 registered trials, 78 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 78 Epilepsy trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Neurological Disorders and Stroke (NINDS) sponsors the most Epilepsy trials on record, review their full trial history before evaluating a specific study. See National Institute of Neurological Disorders and Stroke (NINDS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Epilepsy condition card totals 164 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.