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NCT05283811 · ClinicalTrials.gov registry record · NA
Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
A NA study of Epilepsy, sponsored by Baylor College of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 205
- Enrollment target
- 3
- Study locations
NCT05283811 is a NA study of Epilepsy that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 205 participants, below the 951-participant average among 160 other Epilepsy trials with a reported enrollment target (78% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT05283811, a NA study of Epilepsy, is actively recruiting participants, sponsored by Baylor College of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 205 participants
- Enrollment target
- 3
- Study locations
Study Summary
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad hoc self-programming': 'ad hoc' because these new behavioral repertoires are cobbled together on the fly, based on immediate demand, and then discarded when no longer necessary; 'self-programming' because the brain has to configure itself appropriately based on task demands and some combination of prior experience and/or instruction. The overall goal of our research effort is to understand the neurophysiological and computational basis for ad hoc self-programmed behavior. The previous U01 project (NS 108923) focused on how these programs of action are initially created. The results thus far have revealed tantalizing notions of how the brain represents these programs and navigates through the programs. In this proposal, therefore, the investigators focus on the question of how these mental programs are executed. Based on the preliminary findings and critical conceptual work, the investigators propose that the medial temporal lobe (MTL) and ventral prefrontal cortex (vPFC) creates representations of the critical elements of these mental programs, including concepts such as 'rules' and 'locations', to allow for effective navigation through the algorithm. These data suggest the existence of an 'algorithmic state space' represented in medial temporal and prefrontal regions. This proposal aims to understand the neurophysiological underpinnings of this algorithmic state space in humans. By studying humans, the investigators will profit from our species' powerful capacity for generalization to understand how such state spaces are constructed. The investigators therefore leverage the unique opportunities available in human neuroscience research to record from single cells and popula
Conditions Studied
Interventions
- DEVICE NEUROPACE RNS SYSTEM
- BEHAVIORAL EMU
Study Locations (3)
California
- University of California, Los Angeles - Los Angeles
Texas
- Baylor College of Medicine - Houston
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 205 participants |
| Start Date | 2021-06-01 |
| Est. Completion | 2026-03-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05283811
The ClinicalTrials.gov registry entry for NCT05283811 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 205 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 951-participant average among 160 other Epilepsy trials with a reported enrollment target (78% lower). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Epilepsy appearing as the primary indexed condition, and to 2 interventions - of which NEUROPACE RNS SYSTEM is the first listed.
NCT05283811 reports 3 study locations spanning 3 distinct geographic areas - top geographies include California, Texas, Utah.
Frequently Asked Questions
What is clinical trial NCT05283811 about?
NCT05283811 is a clinical study titled "Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients". Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad ho...
What is the current status of trial NCT05283811?
This trial is currently recruiting. It is a NA study. The enrollment target is 205 participants. The study started on 2021-06-01. Estimated completion is 2026-03-31.
What conditions does trial NCT05283811 study?
This clinical trial studies the following conditions: Epilepsy.
What interventions are being tested in trial NCT05283811?
The interventions under investigation include: NEUROPACE RNS SYSTEM (DEVICE), EMU (BEHAVIORAL).
Who is sponsoring clinical trial NCT05283811?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05283811 being conducted?
This trial has 3 study locations across California, Texas, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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