Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Endothelial Dysfunction clinical trials
Every US clinical trial registered for Endothelial Dysfunction — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
46 US clinical trials · 21 currently recruiting
The research picture
Endothelial Dysfunction has 46 registered US clinical trials, 21 of them open to new participants right now — about 46% of the total.
- 21
- recruiting participants now
- 46%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 6
- top sponsor: University of Colorado, Denver
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
National Institutes of Health Clinical Center (CC)
NCT03253705
Sodium Lowering Vascular Effects Trial
Tulane University
NCT05388032
SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
Vanderbilt University Medical Center
NCT05812755
NightWare and Cardiovascular Health in Veterans With PTSD
VA Office of Research and Development
NCT06419959
EndoPAT Device for Endothelial Dysfunction in ED
University of California, Irvine
NCT06720597
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
University of Colorado, Boulder
NCT05000515
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Nathaniel Jenkins
NCT06454344
Bright Light Exposure in Surgical Patients
University of Colorado, Denver
NCT03822949
Optimizing Pulsatility During Cardiopulmonary Bypass
University of Colorado, Denver
NCT05344573
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Kalie Tommerdahl
NCT05065372
Role of Endothelial Function in SCI CVD Risk
Craig Hospital
NCT06443151
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Medical College of Wisconsin
NCT05808686
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Craig Hospital
NCT07227740
Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
Anna Stanhewicz, PhD
NCT06547619
Endothelial Dysfunction After SCI
Craig Hospital
NCT07227727
Effect of a Daily Supplement on Plasma PAI-1 Levels
University of California, Los Angeles
NCT07469475
Puberty Suppression and Cardiometabolic Health
University of Colorado, Denver
NCT04482374
ACEs, SIRT1, and Premature Vascular Aging in Humans
Nathaniel Jenkins
NCT07073352
Microvascular Dysfunction in Obesity
Florida State University
NCT04087655
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
University of Iowa
NCT06489249
B-Complex: A Nutraceutical SANS Countermeasure
National Aeronautics and Space Administration (NASA)
NCT05366933
The DISCOVER INOCA Prospective Multi-center Registry
Yale University
NCT05288361
Fisetin to Improve Vascular Function in Older Adults
University of Colorado, Boulder
NCT06133634
Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women
Colorado State University
NCT04530916
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Vanderbilt University Medical Center
NCT04769206
Correlation of Endothelial Function and Early Coronary Artery Disease in Humans
Mayo Clinic
NCT00271492
Key Dimensions of PTSD and ED
University of California, Los Angeles
NCT03778307
Vitamin D Repletion in Coronary Artery Disease
Seth I. Sokol, M.D.
NCT01570309
Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls
University Hospitals Cleveland Medical Center
NCT02324179
Effect of Inorganic Nitrate Supplement on Blood Pressure
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NCT03909789
Targeting Inflammation to Treat Cardiovascular Aging
Gary L. Pierce
NCT01775865
NightWare and Cardiovascular Health in Adults With PTSD
University of Colorado, Denver
NCT05365607
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
University Hospitals Cleveland Medical Center
NCT01046682
Electronic Hookah and Endothelial Cell Function
University of California, Los Angeles
NCT04133376
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
Ohio State University
NCT03624569
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
University of Utah
NCT00859833
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
Cedars-Sinai Medical Center
NCT03018366
N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults
Indiana University
NCT01962961
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Colorado State University
NCT03824041
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
Ball State University
NCT05872139
A Phase 1/ Phase 2 Study of TTHX1114(NM141)
Trefoil Therapeutics
NCT04520321
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
University of Colorado, Denver
NCT03112226
Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
Mayo Clinic
NCT01746264
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
University of Colorado, Denver
NCT02122198
Creatine Monohydrate Supplementation and Vascular Endothelial Health
Florida State University
NCT05014659
Trial of Oral Glutamine on Mitochondrial Function in CKD
University of Washington
NCT02838979
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 5 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Endothelial Dysfunction Trial Landscape
ClinicalTrials.gov lists 46 US studies indexed under Endothelial Dysfunction, and 21 of those are currently open to recruitment — roughly 46% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Endothelial Dysfunction shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 16 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Endothelial Dysfunction is led by University of Colorado, Denver with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 46 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Endothelial Dysfunction?
PlainTrial tracks 46 US clinical trials for Endothelial Dysfunction, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Endothelial Dysfunction?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.