Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Endothelial Dysfunction: early-phase trial registry
21 of 46 indexed Endothelial Dysfunction trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #312 of 28,707 conditions by registered trial count.
46 US clinical trials · 21 currently recruiting · #312 of 28,707 conditions by registered trial count
Endothelial Dysfunction: 46 US clinical trials tracked, 21 recruiting.
Endothelial Dysfunction is the subject of 46 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 6 of these trials.
Enrollment posture brief
Registry condition endothelial-dysfunction
OPEN 21 | RECR 46% | LATE 2 | EARLY 16 | RANK #312 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Amyotrophic Lateral Sclerosis (46% recruiting · 103 trials)
Endothelial Dysfunction lists 21 open slots (46% of 46 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Endothelial Dysfunction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Endothelial Dysfunction is recruiting above its size-band peers.
21 of 46 indexed trials (45.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Endothelial Dysfunction trials is spread across many organizations.
University of Colorado, Denver accounts for 6 of 46 trials (13%). 30 distinct sponsors appear on at least one study for this condition label.
-
Most Endothelial Dysfunction trials plan to enrol fewer than 100 people.
Median target enrolment is 46 among the 46 trials that report a genuine target (sentinel values excluded). 38 of those (82.6%) plan for fewer than 100 participants.
-
Endothelial Dysfunction research is mostly interventional.
37 interventional and 9 observational studies make up this index (80.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
46 total, page 1 of 1
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
National Institutes of Health Clinical Center (CC)
NCT03253705
Sodium Lowering Vascular Effects Trial
Tulane University
NCT05388032
SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
Vanderbilt University Medical Center
NCT05812755
NightWare and Cardiovascular Health in Veterans With PTSD
VA Office of Research and Development
NCT06419959
EndoPAT Device for Endothelial Dysfunction in ED
University of California, Irvine
NCT06720597
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
University of Colorado, Boulder
NCT05000515
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Nathaniel Jenkins
NCT06454344
Bright Light Exposure in Surgical Patients
University of Colorado, Denver
NCT03822949
Optimizing Pulsatility During Cardiopulmonary Bypass
University of Colorado, Denver
NCT05344573
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Kalie Tommerdahl
NCT05065372
Role of Endothelial Function in SCI CVD Risk
Craig Hospital
NCT06443151
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Medical College of Wisconsin
NCT05808686
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Craig Hospital
NCT07227740
Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
Anna Stanhewicz, PhD
NCT06547619
Endothelial Dysfunction After SCI
Craig Hospital
NCT07227727
Effect of a Daily Supplement on Plasma PAI-1 Levels
University of California, Los Angeles
NCT07469475
Puberty Suppression and Cardiometabolic Health
University of Colorado, Denver
NCT04482374
ACEs, SIRT1, and Premature Vascular Aging in Humans
Nathaniel Jenkins
NCT07073352
Microvascular Dysfunction in Obesity
Florida State University
NCT04087655
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
University of Iowa
NCT06489249
B-Complex: A Nutraceutical SANS Countermeasure
National Aeronautics and Space Administration (NASA)
NCT05366933
The DISCOVER INOCA Prospective Multi-center Registry
Yale University
NCT05288361
Fisetin to Improve Vascular Function in Older Adults
University of Colorado, Boulder
NCT06133634
Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women
Colorado State University
NCT04530916
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Vanderbilt University Medical Center
NCT04769206
Correlation of Endothelial Function and Early Coronary Artery Disease in Humans
Mayo Clinic
NCT00271492
Key Dimensions of PTSD and ED
University of California, Los Angeles
NCT03778307
Vitamin D Repletion in Coronary Artery Disease
Seth I. Sokol, M.D.
NCT01570309
Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls
University Hospitals Cleveland Medical Center
NCT02324179
Effect of Inorganic Nitrate Supplement on Blood Pressure
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NCT03909789
Targeting Inflammation to Treat Cardiovascular Aging
Gary L. Pierce
NCT01775865
NightWare and Cardiovascular Health in Adults With PTSD
University of Colorado, Denver
NCT05365607
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
University Hospitals Cleveland Medical Center
NCT01046682
Electronic Hookah and Endothelial Cell Function
University of California, Los Angeles
NCT04133376
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
Ohio State University
NCT03624569
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
University of Utah
NCT00859833
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women
Cedars-Sinai Medical Center
NCT03018366
N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults
Indiana University
NCT01962961
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Colorado State University
NCT03824041
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
Ball State University
NCT05872139
A Phase 1/ Phase 2 Study of TTHX1114(NM141)
Trefoil Therapeutics
NCT04520321
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
University of Colorado, Denver
NCT03112226
Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
Mayo Clinic
NCT01746264
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
University of Colorado, Denver
NCT02122198
Creatine Monohydrate Supplementation and Vascular Endothelial Health
Florida State University
NCT05014659
Trial of Oral Glutamine on Mitochondrial Function in CKD
University of Washington
NCT02838979
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 5 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Endothelial Dysfunction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Endothelial Dysfunction trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Endothelial Dysfunction page
46 registered trials, 21 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 21 Endothelial Dysfunction trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Colorado, Denver sponsors the most Endothelial Dysfunction trials on record, review their full trial history before evaluating a specific study. See University of Colorado, Denver's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Endothelial Dysfunction condition card totals 46 registered trials; most-linked intervention Placebo; top US site state Colorado. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.