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NCT06443151 · ClinicalTrials.gov registry record
Role of Endothelial Function in SCI CVD Risk
A clinical trial of Cardiovascular Diseases and Spinal Cord Injuries, sponsored by Craig Hospital.
- Recruiting
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT06443151: Recruiting study of Cardiovascular Diseases and Spinal Cord Injuries, sponsored by Craig Hospital.
NCT06443151 is a study of Cardiovascular Diseases and Spinal Cord Injuries that is actively recruiting participants, run by Craig Hospital. The registered enrollment target is 60 participants, below the 26,974-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06443151, a study of Cardiovascular Diseases and Spinal Cord Injuries, is actively recruiting participants, sponsored by Craig Hospital.
- RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in the body and plays an important role in vessel health. Damage to endothelial cells is known to lead to heart attacks and strokes. Past studies on endothelial cells of people with spinal cord injury have been unclear. The investigators have new data that these cells are unhealthy after spinal cord injury a measurement. This includes measuring endothelial health by directly altering its function using a catheter in the arm and measuring small particles in blood called endothelial microvesicles. If the project is successful, the investigators will learn important information on the health of endothelial cells after spinal cord injury. The investigators will also be able to use these markers of endothelial cell function to create treatments to improve vessel health and prevent heart attacks and strokes later in life in people with spinal cord injury.
Primary Outcome
Total forearm blood flow with be measured by strain gauge venous plethysmography under baseline conditions and under pharmacological manipulation with acetylcholine at increasing concentrations (8, 16, 32ug/ml).
Conditions Studied
Interventions
- PROCEDURE Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid)
- PROCEDURE venous occlusion plethysmography
- DRUG Acetylcholine
- DRUG Sodium Nitroprusside
- DRUG Ascorbic acid
Study Locations (1)
Colorado
- Craig Hospital - Englewood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-09-01 |
| Est. Completion | 2027-03-30 |
What NCT06443151 shows while recruiting
NCT06443151 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 26,974-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (100% lower).
The record links to 3 conditions, with Cardiovascular Diseases appearing as the primary indexed condition, and to 5 interventions - of which Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid) is the first listed.
NCT06443151 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06443151 about?
NCT06443151 is a clinical study titled "Role of Endothelial Function in SCI CVD Risk". Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabe...
What is the current status of trial NCT06443151?
This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2024-09-01. Estimated completion is 2027-03-30.
What conditions does trial NCT06443151 study?
This clinical trial studies the following conditions: Cardiovascular Diseases, Spinal Cord Injuries, Endothelial Dysfunction.
What interventions are being tested in trial NCT06443151?
The interventions under investigation include: Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid) (PROCEDURE), venous occlusion plethysmography (PROCEDURE), Acetylcholine (DRUG), Sodium Nitroprusside (DRUG), Ascorbic acid (DRUG).
Who is sponsoring clinical trial NCT06443151?
This trial is sponsored by Craig Hospital, which has 29 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06443151 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06443151's enrollment target sits among peer trials
60 222nd of 300 higher than 69 of 300 other Cardiovascular Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cardiovascular Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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