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NCT07227740 · ClinicalTrials.gov registry record
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
A clinical trial of Spinal Cord Injuries and Endothelial Dysfunction, sponsored by Craig Hospital.
- Recruiting
- Registry status
- 48
- Enrollment target
- 1
- Study location
NCT07227740 is a study of Spinal Cord Injuries and Endothelial Dysfunction that is actively recruiting participants, run by Craig Hospital. The registered enrollment target is 48 participants, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (21% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07227740, a study of Spinal Cord Injuries and Endothelial Dysfunction, is actively recruiting participants, sponsored by Craig Hospital.
- RECRUITING
- Registry status
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly understood. The investigators aim to uncover why this happens and find ways to prevent it. Our research focuses on how important cells which line blood vessels, called endothelial cells, function after SCI. The investigators test endothelial function in live conscious people with SCI. The investigators also study signaling molecules endothelial cells release called endothelial cell derived microvesicles (EMVs), which the investigators can measure in blood to tell us the health of endothelial cells. By using these rigorous tests of vascular function, the investigators have determined that endothelial cells appear dysfunctional after SCI. The investigators also know that many men with SCI have low testosterone levels. Our team has studied testosterone's effects on endothelial dysfunction and believe low testosterone may be contributing to endothelial dysfunction after SCI. By understanding these mechanisms, the investigators hope to improve the lives of those living with SCI and reduce their risk for heart attacks and strokes. The investigators propose to study the influence of testosterone on endothelial function by using state-of-the-art clinical and laboratory experiments to assess endothelial function in men with SCI with low and normal testosterone levels.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Intra-arterial Infusion of Vasoactive Agents
- DIAGNOSTIC_TEST Intra-arterial Vitamin C Infusion
- DIAGNOSTIC_TEST Blood Sampling
Study Locations (1)
Colorado
- Craig Hospital - Englewood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-07-15 |
| Est. Completion | 2028-07-14 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07227740
The ClinicalTrials.gov registry entry for NCT07227740 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (21% lower). The listed sponsor is Craig Hospital, which has 29 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 3 interventions - of which Intra-arterial Infusion of Vasoactive Agents is the first listed.
NCT07227740 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT07227740 about?
NCT07227740 is a clinical study titled "Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury". Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly under...
What is the current status of trial NCT07227740?
This trial is currently recruiting. The enrollment target is 48 participants. The study started on 2025-07-15. Estimated completion is 2028-07-14.
What conditions does trial NCT07227740 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency.
What interventions are being tested in trial NCT07227740?
The interventions under investigation include: Intra-arterial Infusion of Vasoactive Agents (DIAGNOSTIC_TEST), Intra-arterial Vitamin C Infusion (DIAGNOSTIC_TEST), Blood Sampling (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07227740?
This trial is sponsored by Craig Hospital, which has 29 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07227740 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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