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2026 data Public-data reference. official source

Clear Cell Renal Cell Carcinoma

Open-data reference.

46 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 1,040 participants

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Alliance for Clinical Trials in Oncology

NCT06661720

RECRUITING Phase 1 362 participants

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

Arcus Biosciences

NCT05536141

RECRUITING Phase 1 307 participants

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

Xencor

NCT05433142

RECRUITING Phase 1 224 participants

A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Pfizer

NCT07227415

RECRUITING Phase 1 115 participants

A Beta-only IL-2 ImmunoTherapY Study

Medicenna Therapeutics

NCT05086692

RECRUITING Phase 1 100 participants

Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC

M.D. Anderson Cancer Center

NCT05663710

RECRUITING Phase 2 91 participants

An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer

Jonsson Comprehensive Cancer Center

NCT06447103

RECRUITING Phase 2 89 participants

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Rahul Aggarwal

NCT03682289

RECRUITING Phase 2 72 participants

Cemiplimab or Cemiplimab and Fianlimab After Stereotactic Body Radiotherapy in Clear Cell Renal Cell Carcinoma

University of Oklahoma

NCT07223541

RECRUITING Phase 2 70 participants

Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

Karie Runcie

NCT06863311

RECRUITING Phase 1 67 participants

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Novelty Nobility

NCT06805825

RECRUITING Phase 1 35 participants

[18F]PT2385 PET/CT in Patients With Renal Cell Carcinoma

Orhan Kemal Oz

NCT04989959

RECRUITING Phase 1 30 participants

Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

Neomorph

NCT07300241

RECRUITING Phase 2 10 participants

Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal Cell Carcinoma (BLAZE)

M.D. Anderson Cancer Center

NCT07187778

ACTIVE NOT RECRUITING Phase 3 1,175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

National Cancer Institute (NCI)

NCT03793166

ACTIVE NOT RECRUITING Phase 3 681 participants

A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread

Bristol-Myers Squibb

NCT04810078

ACTIVE NOT RECRUITING 589 participants

Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study

Mayo Clinic

NCT06339138

ACTIVE NOT RECRUITING Phase 1 152 participants

Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors

National Cancer Institute (NCI)

NCT02496208

ACTIVE NOT RECRUITING Phase 1 141 participants

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

23andMe

NCT05199272

ACTIVE NOT RECRUITING Phase 2 134 participants

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

National Cancer Institute (NCI)

NCT04071223

ACTIVE NOT RECRUITING Phase 3 129 participants

Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery

National Cancer Institute (NCI)

NCT01575548

ACTIVE NOT RECRUITING Phase 1 110 participants

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)

Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT02293980

ACTIVE NOT RECRUITING Early Phase 1 104 participants

Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery

M.D. Anderson Cancer Center

NCT02210117

ACTIVE NOT RECRUITING Phase 2 62 participants

Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer

University of Southern California

NCT03092856

ACTIVE NOT RECRUITING Phase 1 60 participants

A Phase 1/2 Trial of ADI-270 in ccRCC

Adicet Therapeutics

NCT06480565

ACTIVE NOT RECRUITING Phase 2 60 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

National Cancer Institute (NCI)

NCT03284385

ACTIVE NOT RECRUITING Phase 1 57 participants

Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer

Ajjai Alva, MD

NCT03308396

ACTIVE NOT RECRUITING Phase 1 55 participants

Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab

Mohammed Milhem

NCT05363631

ACTIVE NOT RECRUITING Phase 1 51 participants

Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer

Roswell Park Cancer Institute

NCT01684397

ACTIVE NOT RECRUITING Phase 1 47 participants

Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer

National Cancer Institute (NCI)

NCT01038778

ACTIVE NOT RECRUITING Phase 2 22 participants

Prior Axitinib as a Determinant of Outcome of Renal Surgery

University of California, San Diego

NCT03438708

ACTIVE NOT RECRUITING Phase 2 22 participants

Neoadjuvant Cabozantinib in Treating Patients With Locally Advanced Kidney Cancer

Emory University

NCT04022343

ACTIVE NOT RECRUITING Phase 2 9 participants

Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer

Memorial Sloan Kettering Cancer Center

NCT05239533

COMPLETED Phase 3 1,943 participants

Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery

National Cancer Institute (NCI)

NCT00326898

COMPLETED Phase 2 291 participants

Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Children's Oncology Group

NCT00335556

COMPLETED Phase 2 157 participants

Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer

National Cancer Institute (NCI)

NCT01835158

COMPLETED Phase 1 106 participants

Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

Fred Hutchinson Cancer Center

NCT00027820

COMPLETED Phase 1 97 participants

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

MedImmune

NCT02118337

COMPLETED Phase 2 80 participants

Sorafenib Tosylate With or Without Recombinant Interferon Alfa-2b in Treating Patients With Metastatic Kidney Cancer

National Cancer Institute (NCI)

NCT00126594

COMPLETED Phase 2 69 participants

CB-839 With Everolimus vs. Placebo With Everolimus in Participants With Renal Cell Carcinoma (RCC)

Calithera Biosciences

NCT03163667

COMPLETED Early Phase 1 29 participants

Tremelimumab With or Without Cryoablation in Treating Patients With Metastatic Kidney Cancer

M.D. Anderson Cancer Center

NCT02626130

COMPLETED Phase 2 28 participants

Pazopanib Hydrochloride in Treating Patients With Stage IV Kidney Cancer

City of Hope Medical Center

NCT01157091

COMPLETED Phase 1 26 participants

Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma

Arrowhead Pharmaceuticals

NCT04169711

COMPLETED Phase 1 19 participants

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors

CRISPR Therapeutics

NCT05795595

COMPLETED Early Phase 1 17 participants

Daratumumab in Treating Patients with Muscle Invasive Bladder Cancer or Metastatic Kidney Cancer

M.D. Anderson Cancer Center

NCT03473730

COMPLETED Phase 1 12 participants

Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer

Jonsson Comprehensive Cancer Center

NCT01826877

Phase Distribution

PhaseTrial count
Early Phase 1 24
Phase 2 16
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Clear Cell Renal Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 46 US studies indexed under Clear Cell Renal Cell Carcinoma, and 14 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Clear Cell Renal Cell Carcinoma shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 40 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Clear Cell Renal Cell Carcinoma is led by National Cancer Institute (NCI) with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 46 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Clear Cell Renal Cell Carcinoma?

PlainTrial tracks 46 US clinical trials for Clear Cell Renal Cell Carcinoma, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Clear Cell Renal Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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