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2026 data Public-data reference. official source

Hematologic Malignancies

Open-data reference.

46 US clinical trials · 22 currently recruiting

Active & Recent Trials

RECRUITING 99,999 participants

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Center for International Blood and Marrow Transplant Research

NCT01351545

RECRUITING Phase 3 3,500 participants

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Merck Sharp & Dohme

NCT03486873

RECRUITING NA 500 participants

DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

UNC Lineberger Comprehensive Cancer Center

NCT06296368

RECRUITING Phase 2 490 participants

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Merck Sharp & Dohme

NCT04728893

RECRUITING Phase 1 280 participants

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Incyte Corporation

NCT07195916

RECRUITING Phase 1 265 participants

Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...

National Cancer Institute (NCI)

NCT05470491

RECRUITING Phase 3 190 participants

Digital Health Intervention for Self-Management and Telemonitoring in Chimeric Antigen Receptor (CAR-T) Therapy

City of Hope Medical Center

NCT07186192

RECRUITING Phase 1 160 participants

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

Sellas Life Sciences Group

NCT04588922

RECRUITING Phase 1 155 participants

Phase I Trial Integrating HLA-Haploidentical Anti-CD19 CAR-T Cells With Post-Transplantation Cyclophosphamide-Based HLA-Haploidentical Hematopoietic Cell Transplantation

National Cancer Institute (NCI)

NCT07162038

RECRUITING Phase 2 150 participants

IVIG for Infection Prevention After CAR-T-Cell Therapy

Fred Hutchinson Cancer Center

NCT05952804

RECRUITING 135 participants

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

National Heart, Lung, and Blood Institute (NHLBI)

NCT05724121

RECRUITING Phase 1 122 participants

A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

Kumquat Biosciences

NCT06645886

RECRUITING Phase 1 117 participants

A Phase 1 Study of IM-1021 in Participants With Advanced Cancer

Immunome

NCT06823167

RECRUITING Phase 2 100 participants

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

Pulmotect

NCT06665100

RECRUITING Early Phase 1 90 participants

APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies

Ascentage Pharma Group

NCT03537482

RECRUITING Phase 2 60 participants

Risk-ADAPTed Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation

University of California, Irvine

NCT06028828

RECRUITING Phase 2 40 participants

A Study of Ruxolitinib for Preventing Graft-Versus-Host Disease in People With a Hematologic Malignancy Who Will Receive a Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT07359859

RECRUITING NA 38 participants

Prophylactic TCRaB+ and CD19+ Depleted Donor Lymphocyte Infusion After Allogeneic Stem Cell Transplant in High-Risk Patients With Hematologic Malignancies

University of Wisconsin, Madison

NCT07285668

RECRUITING Phase 2 35 participants

Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

M.D. Anderson Cancer Center

NCT06807606

RECRUITING Phase 1 26 participants

Post-Transplant Cyclophosphamide in Patients Aged >/= 65 Years Undergoing Haploidentical Transplant

Ronald Paquette

NCT05849207

RECRUITING Phase 1 24 participants

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

Acrotech Biopharma

NCT07036133

RECRUITING Phase 1 12 participants

A Study to Assess the Effect of Venetoclax on Ethinyl Estradiol and Levonorgestrel in Female Participants With Different Hematological Malignancies

AbbVie

NCT03557619

ACTIVE NOT RECRUITING 14,266 participants

Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study

Mayo Clinic

NCT02457962

ACTIVE NOT RECRUITING Phase 2 270 participants

Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord Transplantation

Weill Medical College of Cornell University

NCT01810588

ACTIVE NOT RECRUITING Phase 2 60 participants

Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies with Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device

Julie-An M. Talano

NCT02600208

ACTIVE NOT RECRUITING Phase 1 39 participants

Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT04098393

COMPLETED 252 participants

Associations Between Pre-transplant Comorbidities and Post-transplant Toxicities and Quality of Life

Fred Hutchinson Cancer Center

NCT01930981

COMPLETED Phase 2 57 participants

Study of AP23573 in Patients With Relapsed or Refractory Hematologic Malignancies (8669-024)(COMPLETED)

Merck Sharp & Dohme

NCT00086125

COMPLETED Phase 2 56 participants

Adult Double Cord Blood Transplant Study

Center for International Blood and Marrow Transplant Research

NCT00514579

COMPLETED Phase 2 55 participants

Allogeneic Bone Marrow Transplantation With Matched Unrelated Donors for Patients With Hematologic Malignancies

Emory University

NCT00208923

COMPLETED Phase 1 53 participants

Phase 1/2 Study of Carfilzomib for the Prevention of Relapse and GVHD in Allo-HCT for Hematologic Malignancies

University of Michigan Rogel Cancer Center

NCT02145403

COMPLETED NA 47 participants

Infection Rates of Myeloablative Allo SCT Recipients Receiving Neutropenic Diets Versus Non-Neutropenic Diets

Duke University

NCT01687231

COMPLETED Phase 1 47 participants

A Study Of PF-04449913 In Select Hematologic Malignancies

Pfizer

NCT00953758

COMPLETED Phase 3 46 participants

Oral Posaconazole Three Times Per Day vs Weekly High Dose Amphotericin B Lipid Complex (ABLC)

M.D. Anderson Cancer Center

NCT00750737

COMPLETED Phase 1 45 participants

Bortezomib Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease (GVHD) After Mismatched Allogeneic Non-Myeloablative Blood Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT00369226

COMPLETED Phase 1 36 participants

Safety Study of MultiStem® in Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplasia

Healios K.K.

NCT00677859

COMPLETED Phase 1 34 participants

Haploidentical Hematopoietic Stem Cell Transplantation Using A Novel Clofarabine Containing Conditioning Regimen For Patients With Refractory Hematologic Malignancies

St. Jude Children's Research Hospital

NCT00824135

COMPLETED Phase 1 32 participants

Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02342613

COMPLETED NA 28 participants

IUdR/BUdR Cell Cycle Labelling

M.D. Anderson Cancer Center

NCT00042250

COMPLETED Phase 1 27 participants

A Two-Step Approach to Bone Marrow Transplant Using Cells From A Partially-Matched Relative

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT00429143

COMPLETED 25 participants

Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

University of California, San Francis

NCT03609827

COMPLETED Phase 1 20 participants

Triciribine Phosphate Monohydrate (TCN-PM, VD-0002) in Adult Patients With Advanced Hematologic Malignancies

Prescient Therapeutics

NCT00642031

COMPLETED Phase 1 19 participants

Phase I Study of Continuous Infusion Schedule of FMdC in Hematologic Malignancies

M.D. Anderson Cancer Center

NCT00061620

COMPLETED Phase 2 14 participants

A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies

Yale University

NCT00402714

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

COMPLETED NA 10 participants

Granulocyte Colony Stimulating Factor (G-CSF) for Bone Marrow Transplant (BMT)

Emory University

NCT00231309

Phase Distribution

PhaseTrial count
Early Phase 1 21
Phase 2 12
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hematologic Malignancies Trial Landscape

ClinicalTrials.gov lists 46 US studies indexed under Hematologic Malignancies, and 22 of those are currently open to recruitment — roughly 48% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hematologic Malignancies shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 33 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hematologic Malignancies is led by M.D. Anderson Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 46 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hematologic Malignancies?

PlainTrial tracks 46 US clinical trials for Hematologic Malignancies, of which 22 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hematologic Malignancies?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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