Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07227727 · ClinicalTrials.gov registry record
Endothelial Dysfunction After SCI
A clinical trial of Spinal Cord Injuries and Endothelial Dysfunction, sponsored by Craig Hospital.
- Recruiting
- Registry status
- 40
- Enrollment target
- 1
- Study location
NCT07227727: Recruiting study of Spinal Cord Injuries and Endothelial Dysfunction, sponsored by Craig Hospital.
NCT07227727 is a study of Spinal Cord Injuries and Endothelial Dysfunction that is actively recruiting participants, run by Craig Hospital. The registered enrollment target is 40 participants, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (34% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07227727, a study of Spinal Cord Injuries and Endothelial Dysfunction, is actively recruiting participants, sponsored by Craig Hospital.
- RECRUITING
- Registry status
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
Primary Outcome
Total forearm blood flow with be measured by strain gauge venous plethysmography under baseline conditions and under pharmacological manipulation with acetylcholine and isoproterenol at increasing concentrations.
Conditions Studied
Interventions
- PROCEDURE Intra-arterial Infusion of Vasoactive Agents
- PROCEDURE Intra-arterial Vitamin C Infusion
- PROCEDURE Blood Sampling
Study Locations (1)
Colorado
- Craig Hospital - Englewood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-07-31 |
| Est. Completion | 2027-07-30 |
What NCT07227727 shows while recruiting
NCT07227727 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (34% lower).
The record links to 2 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 3 interventions - of which Intra-arterial Infusion of Vasoactive Agents is the first listed.
NCT07227727 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT07227727 about?
NCT07227727 is a clinical study titled "Endothelial Dysfunction After SCI". This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord ...
What is the current status of trial NCT07227727?
This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2025-07-31. Estimated completion is 2027-07-30.
What conditions does trial NCT07227727 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Endothelial Dysfunction.
What interventions are being tested in trial NCT07227727?
The interventions under investigation include: Intra-arterial Infusion of Vasoactive Agents (PROCEDURE), Intra-arterial Vitamin C Infusion (PROCEDURE), Blood Sampling (PROCEDURE).
Who is sponsoring clinical trial NCT07227727?
This trial is sponsored by Craig Hospital, which has 29 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07227727 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07227727's enrollment target sits among peer trials
40 72nd of 202 higher than 124 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
RECRUITING · NA
-
Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury
RECRUITING · NA
-
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
RECRUITING · NA
-
Transcutaneous Spinal Stimulation and Exercise for Locomotion
RECRUITING · NA
-
HAPPINESS: cHAnging the Perceived Pain INtEnSity in Populations With Spinal Cord Injury and With Health Disparities: A Feasibility Study
RECRUITING · NA
-
Effectiveness of the Collaborative Community Clinic for Persons With Spinal Cord Injury and Disease
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT06358040 · started 2026-10 · NA
Opioid Dispenser for Microdiscectomy/Laminectomy