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NCT03822949 · ClinicalTrials.gov registry record · NA
Bright Light Exposure in Surgical Patients
A NA study of Critical Illness and Endothelial Dysfunction, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT03822949 is a NA study of Critical Illness and Endothelial Dysfunction that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 70 participants, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03822949, a NA study of Critical Illness and Endothelial Dysfunction, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize that light therapy leads to Per2 dependent metabolic optimization in the human cardiac tissue. Therefore, a small piece of human heart tissue from the right atrium will be collected during cardiac cannulation, which will be otherwise discarded. 2. Critical illness (being in the intensive care unit) results in circadian malfunction and vessels not working. Vessel function is controlled by the body's circadian clock. Intense light boosts the circadian clock and the vessel function in animal studies. Vessels not working well in critical ill patients results in a myriad of severe diseases (delirium, stroke, heart attack, organ damage etc). Thus we will test if intense light can be used to boost the circadian clock and the associated vessel function in critical ill patients.
Conditions Studied
Interventions
- DEVICE Day Light
- DEVICE Placebo light
- DEVICE ICU Intense Light
- DEVICE ICU Placebo light
Study Locations (1)
Colorado
- University of Colorado Denver | Anschutz Medical Campus - Denver
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2019-07-12 |
| Est. Completion | 2026-07-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03822949
The ClinicalTrials.gov registry entry for NCT03822949 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (98% lower). The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Critical Illness appearing as the primary indexed condition, and to 4 interventions - of which Day Light is the first listed.
NCT03822949 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT03822949 about?
NCT03822949 is a clinical study titled "Bright Light Exposure in Surgical Patients". 1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels...
What is the current status of trial NCT03822949?
This trial is currently recruiting. It is a NA study. The enrollment target is 70 participants. The study started on 2019-07-12. Estimated completion is 2026-07-01.
What conditions does trial NCT03822949 study?
This clinical trial studies the following conditions: Critical Illness, Endothelial Dysfunction, Myocardial Ischemia.
What interventions are being tested in trial NCT03822949?
The interventions under investigation include: Day Light (DEVICE), Placebo light (DEVICE), ICU Intense Light (DEVICE), ICU Placebo light (DEVICE).
Who is sponsoring clinical trial NCT03822949?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03822949 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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