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NCT03778307 · ClinicalTrials.gov registry record
Key Dimensions of PTSD and ED
A clinical trial of PTSD and Trauma, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- 168
- Enrollment target
- 1
- Study location
NCT03778307: Completed study of PTSD and Trauma, sponsored by University of California, Los Angeles.
NCT03778307 is a study of PTSD and Trauma that has completed, run by University of California, Los Angeles. The registered enrollment target is 168 participants, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (44% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03778307, a study of PTSD and Trauma, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- 168 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will test whether endothelial dysfunction could be the early subclinical mechanism by which posttraumatic stress disorder (PTSD) increases cardiovascular disease (CVD) risk, and whether posttraumatic fear-a key component of PTSD-or another PTSD dimension could be the target to offset that risk. The results of this study may help trauma-exposed individuals who are at risk of having CVD events.
Primary Outcome
FMD is the percent difference in diameter of the brachial artery, before and after occlusion. Impaired endothelial function occurs when blood vessels are unable to dilate fully in response to nitric oxide synthesis and release, which is manifested as impaired endothelium-dependent vasodilation (i.e., lower FMD). Lower FMD has been associated with the degree of coronary atherosclerosis and predicts CVD events.
Conditions Studied
Interventions
- BEHAVIORAL Psychophysiological fear conditioning and extinction task
- BEHAVIORAL Eyetracking task
Study Locations (1)
California
- UCLA - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2019-11-20 |
| Est. Completion | 2025-06-30 |
What the finished NCT03778307 record still lists
NCT03778307 is an observational study that tracks outcomes without assigning an intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (44% lower).
The record links to 3 conditions, with PTSD appearing as the primary indexed condition, and to 2 interventions - of which Psychophysiological fear conditioning and extinction task is the first listed.
NCT03778307 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03778307 about?
NCT03778307 is a clinical study titled "Key Dimensions of PTSD and ED". This study will test whether endothelial dysfunction could be the early subclinical mechanism by which posttraumatic stress disorder (PTSD) increases cardiovascular disease (CVD) risk, and whether posttraumatic fear-a key component of PTSD-or another PTSD dimension could be the target to offset that...
What is the current status of trial NCT03778307?
This trial is currently completed. The enrollment target is 168 participants. The study started on 2019-11-20. Estimated completion is 2025-06-30.
What conditions does trial NCT03778307 study?
This clinical trial studies the following conditions: PTSD, Trauma, Endothelial Dysfunction.
What interventions are being tested in trial NCT03778307?
The interventions under investigation include: Psychophysiological fear conditioning and extinction task (BEHAVIORAL), Eyetracking task (BEHAVIORAL).
Who is sponsoring clinical trial NCT03778307?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03778307 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03778307's enrollment target sits among peer trials
168 37th of 154 higher than 116 of 154 other PTSD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PTSD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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