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Cognitive Dysfunction: early-phase trial registry
23 of 46 indexed Cognitive Dysfunction trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #312 of 28,707 conditions by registered trial count.
46 US clinical trials · 23 currently recruiting · #312 of 28,707 conditions by registered trial count
Cognitive Dysfunction: 46 US clinical trials tracked, 23 recruiting.
Cognitive Dysfunction is the subject of 46 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Dartmouth-Hitchcock Medical Center, running 5 of these trials.
Enrollment posture brief
Registry condition cognitive-dysfunction
OPEN 23 | RECR 50% | LATE 1 | EARLY 8 | RANK #312 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)
Cognitive Dysfunction lists 23 open slots (50% of 46 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cognitive Dysfunction on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cognitive Dysfunction is recruiting above its size-band peers.
23 of 46 indexed trials (50%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cognitive Dysfunction trials is spread across many organizations.
Dartmouth-Hitchcock Medical Center accounts for 5 of 46 trials (10.9%). 34 distinct sponsors appear on at least one study for this condition label.
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Typical Cognitive Dysfunction enrolment sits around 75 participants.
Median target enrolment is 75 among the 46 trials that report a genuine target (sentinel values excluded). 25 of those (54.3%) plan for fewer than 100 participants.
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Cognitive Dysfunction research is mostly interventional.
34 interventional and 12 observational studies make up this index (73.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
46 total, page 1 of 1
PREsurgical Cognitive Evaluation Via Digital clockfacEdrawing
University of Florida
NCT03175302
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
University of Washington
NCT05596760
Vanderbilt Memory and Aging Project
Vanderbilt University Medical Center
NCT05372159
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Polyphenols and Cognitive Decline
University of California, Los Angeles
NCT06507254
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
University of Virginia
NCT05565833
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
Dartmouth-Hitchcock Medical Center
NCT06930846
HOBSCOTCH-MS-Efficacy Trial
Dartmouth-Hitchcock Medical Center
NCT06951919
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
University of Florida
NCT05830942
Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond
VA Office of Research and Development
NCT04109027
Cognitive Remediation
Cutter Lindbergh
NCT07171450
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
University of California, Los Angeles
NCT04558164
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
University of Alabama at Birmingham
NCT05965518
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Joseph McCollom
NCT05014399
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
Mclean Hospital
NCT05245903
The Better, Harder, Faster, Stronger Study
Wake Forest University Health Sciences
NCT07220512
Surviving Daily Life
Thomas Jefferson University
NCT07054723
Long COVID Brain Fog: Cognitive Rehabilitation Trial
University of Alabama at Birmingham
NCT06095297
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
Portland VA Medical Center
NCT06728774
A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
Kessler Foundation
NCT06238492
Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study
Kessler Foundation
NCT06452264
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
Michal Schnaider Beeri, Ph.D.
NCT07392723
Stem Cell Therapy for Early Alzheimer's Disease
Paul E Schulz
NCT06775964
ToolBox Detect: Low Cost Detection of Cognitive Decline in Primary Care Settings
Northwestern University
NCT04852601
Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias
Anne Murray
NCT07224139
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease
Janssen Research & Development
NCT04619420
Improving Cognition After Cancer
University of California, San Diego
NCT04049695
Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-Life Depression
University of Illinois at Chicago
NCT05331599
Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia
University of Texas Southwestern Medical Center
NCT04951700
Transferring Speed of Processing Gains to Everyday Cognitive Tasks After Stroke
University of Alabama at Birmingham
NCT05162781
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
New York State Psychiatric Institute
NCT05690503
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS)
Dartmouth-Hitchcock Medical Center
NCT06145737
HOBSCOTCH for People With Post Acute COVID-19 Syndrome (PACS)
Dartmouth-Hitchcock Medical Center
NCT06391489
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Parkinson's)
Dartmouth-Hitchcock Medical Center
NCT06260228
Characteristics and Outcomes of a Capacity-to-Consent Assessment Service
National Institutes of Health Clinical Center (CC)
NCT03258606
Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia
Targacept
NCT01488929
Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil
Wake Forest University Health Sciences
NCT02822573
A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research
University of Wisconsin, Madison
NCT05444244
Noninvasive Brain Stimulation for Mild Cognitive Impairment
Palo Alto Veterans Institute for Research
NCT03331796
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
University of Colorado, Denver
NCT04600323
Humanity Neurotech Device Clinical Trial in Adults With Long COVID Cognitive Dysfunction
Icahn School of Medicine at Mount Sinai
NCT06739668
Docosahexaenoic Acid (DHA) To Prevent Development of Cognitive Dysfunction Due to Chemotherapy
Carol Fabian, MD
NCT02517502
Brain Vascular and Neurocognitive Health
The University of Texas at Arlington
NCT06497413
Computer Cognitive Training for Post-acute COVID-19 Syndrome
Nova Southeastern University
NCT05338749
A Pilot Randomized Controlled Trial: CoINTEGRATE
University of Michigan
NCT05732285
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Cognitive Dysfunction records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cognitive Dysfunction trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cognitive Dysfunction page
46 registered trials, 23 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 23 Cognitive Dysfunction trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Dartmouth-Hitchcock Medical Center sponsors the most Cognitive Dysfunction trials on record, review their full trial history before evaluating a specific study. See Dartmouth-Hitchcock Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cognitive Dysfunction condition card totals 46 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.