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NCT02122198 · ClinicalTrials.gov registry record · NA
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
A NA study of Cardiovascular Disease and Cognitive Impairment, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
- 2
- Study locations
NCT02122198 is a NA study of Cardiovascular Disease and Cognitive Impairment that has completed, run by University of Colorado, Denver. The registered enrollment target is 17 participants, below the 2,713-participant average among 136 other Cardiovascular Disease trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT02122198, a NA study of Cardiovascular Disease and Cognitive Impairment, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
- 2
- Study locations
Study Summary
Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and function occur when estrogen levels are decreased. Estrogen is also important for maintaining healthy blood vessels which also support normal cognitive function. In Alzheimer's disease and other types of dementia, there is significant damage to the blood vessels in the brain. This study will test whether changes in brain activity and function with the loss of estrogen are related to changes in vascular function. The investigators will measure vascular function using ultrasound, and brain activity using MRI scans in women who are enrolled in the Females, Aging, Metabolism and Exercise (FAME) study (NCT01712230). In the FAME study, healthy premenopausal women either take a medication to decrease their estrogen levels, or a placebo. This sub-study may provide new information about how estrogen affects vascular function and cognitive function, and lead to new ways to prevent or delay cognitive impairment or dementia.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Leuprolide acetate
- DRUG Estradiol
- DRUG Medroxyprogesterone
Study Locations (2)
Colorado
- University of Colorado Anschutz Medical Campus - Aurora
- University of Colorado Boulder Intermountain Neuroimaging Consortium - Boulder
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2014-09-08 |
| Est. Completion | 2017-09-15 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02122198
The ClinicalTrials.gov registry entry for NCT02122198 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 17 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,713-participant average among 136 other Cardiovascular Disease trials with a reported enrollment target (99% lower). The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Cardiovascular Disease appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT02122198 reports 2 study locations spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT02122198 about?
NCT02122198 is a clinical study titled "Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women". Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and function occur when estrogen levels are decreased. Estrogen is also im...
What is the current status of trial NCT02122198?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2014-09-08. Estimated completion is 2017-09-15.
What conditions does trial NCT02122198 study?
This clinical trial studies the following conditions: Cardiovascular Disease, Cognitive Impairment, Endothelial Dysfunction, Executive Dysfunction.
What interventions are being tested in trial NCT02122198?
The interventions under investigation include: Placebo (DRUG), Leuprolide acetate (DRUG), Estradiol (DRUG), Medroxyprogesterone (DRUG).
Who is sponsoring clinical trial NCT02122198?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02122198 being conducted?
This trial has 2 study locations across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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