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NCT06080646 · ClinicalTrials.gov registry record
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
A clinical trial of Depression and Major Depressive Disorder, sponsored by San Francisco Veterans Affairs Medical Center.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT06080646 is a study of Depression and Major Depressive Disorder that is actively recruiting participants, run by San Francisco Veterans Affairs Medical Center. The registered enrollment target is 150 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06080646, a study of Depression and Major Depressive Disorder, is actively recruiting participants, sponsored by San Francisco Veterans Affairs Medical Center.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.
Conditions Studied
Interventions
- OTHER cross-sectional MRI and EEG assessments (NO INTERVENTION)
Study Locations (1)
California
- San Francisco Healthcare System - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2021-06-01 |
| Est. Completion | 2025-09-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06080646
The ClinicalTrials.gov registry entry for NCT06080646 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (81% lower). The listed sponsor is San Francisco Veterans Affairs Medical Center, which has 15 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which cross-sectional MRI and EEG assessments (NO INTERVENTION) is the first listed.
NCT06080646 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06080646 about?
NCT06080646 is a clinical study titled "Reward Processing and Depressive Subtypes: Identifying Neural Biotypes". Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mecha...
What is the current status of trial NCT06080646?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2021-06-01. Estimated completion is 2025-09-01.
What conditions does trial NCT06080646 study?
This clinical trial studies the following conditions: Depression, Major Depressive Disorder, Depressive Symptoms, Depressive Disorder, Anhedonia.
What interventions are being tested in trial NCT06080646?
The interventions under investigation include: cross-sectional MRI and EEG assessments (NO INTERVENTION) (OTHER).
Who is sponsoring clinical trial NCT06080646?
This trial is sponsored by San Francisco Veterans Affairs Medical Center, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06080646 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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