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NCT06080646 · ClinicalTrials.gov registry record
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
A clinical trial of Depression and Major Depressive Disorder, sponsored by San Francisco Veterans Affairs Medical Center.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT06080646: Recruiting study of Depression and Major Depressive Disorder, sponsored by San Francisco Veterans Affairs Medical Center.
NCT06080646 is a study of Depression and Major Depressive Disorder that is actively recruiting participants, run by San Francisco Veterans Affairs Medical Center. The registered enrollment target is 150 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06080646, a study of Depression and Major Depressive Disorder, is actively recruiting participants, sponsored by San Francisco Veterans Affairs Medical Center.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.
Conditions Studied
Interventions
- OTHER cross-sectional MRI and EEG assessments (NO INTERVENTION)
Study Locations (1)
California
- San Francisco Healthcare System - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2021-06-01 |
| Est. Completion | 2025-09-01 |
What NCT06080646 shows while recruiting
NCT06080646 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (81% lower).
The record links to 6 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which cross-sectional MRI and EEG assessments (NO INTERVENTION) is the first listed.
NCT06080646 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06080646 about?
NCT06080646 is a clinical study titled "Reward Processing and Depressive Subtypes: Identifying Neural Biotypes". Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mecha...
What is the current status of trial NCT06080646?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2021-06-01. Estimated completion is 2025-09-01.
What conditions does trial NCT06080646 study?
This clinical trial studies the following conditions: Depression, Major Depressive Disorder, Depressive Symptoms, Depressive Disorder, Anhedonia.
What interventions are being tested in trial NCT06080646?
The interventions under investigation include: cross-sectional MRI and EEG assessments (NO INTERVENTION) (OTHER).
Who is sponsoring clinical trial NCT06080646?
This trial is sponsored by San Francisco Veterans Affairs Medical Center, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06080646 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06080646's enrollment target sits among peer trials
150 249th of 679 higher than 416 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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