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NCT05925322 · ClinicalTrials.gov registry record · NA
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
A NA study of Depression and Major Depressive Disorder, sponsored by Weill Medical College of Cornell University.
- Recruiting
- Registry status
- NA
- Development phase
- 128
- Enrollment target
- 1
- Study location
NCT05925322: Recruiting NA study of Depression and Major Depressive Disorder, sponsored by Weill Medical College of Cornell University.
NCT05925322 is a NA study of Depression and Major Depressive Disorder that is actively recruiting participants, run by Weill Medical College of Cornell University. The registered enrollment target is 128 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05925322, a NA study of Depression and Major Depressive Disorder, is actively recruiting participants, sponsored by Weill Medical College of Cornell University.
- RECRUITING
- Registry status
- NA
- Development phase
- 128 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
Primary Outcome
Change in resting state fMRI connectivity of functional networks representing structures previously associated with the Positive Valence System (Dorsal anterior cingulate cortex \[dACC\], the Subgenual Anterior Cingulate Cortex \[sgACC\], and the basal forebrain/nucleus accumbens \[NAcc\]). The investigators will also test between-network connectivity between the positive valence system and the default mode-, salience-, and fronto-parietal networks. Functional connectivity within- and between-ne
Conditions Studied
Interventions
- BEHAVIORAL "Engage & Connect" Psychotherapy
- BEHAVIORAL Symptom Review and Psychoeducation (SRP)
Study Locations (1)
New York
- Weill Cornell Medicine - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2023-09-18 |
| Est. Completion | 2028-09-30 |
| Phase | NA |
What NCT05925322 shows while recruiting
NCT05925322 is an interventional study that assigns participants to a tested intervention. The registered 128 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (84% lower).
The record links to 4 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which "Engage & Connect" Psychotherapy is the first listed.
NCT05925322 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05925322 about?
NCT05925322 is a clinical study titled "Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality". The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
What is the current status of trial NCT05925322?
This trial is currently recruiting. It is a NA study. The enrollment target is 128 participants. The study started on 2023-09-18. Estimated completion is 2028-09-30.
What conditions does trial NCT05925322 study?
This clinical trial studies the following conditions: Depression, Major Depressive Disorder, Suicidal Ideation, Depressive Disorder.
What interventions are being tested in trial NCT05925322?
The interventions under investigation include: "Engage & Connect" Psychotherapy (BEHAVIORAL), Symptom Review and Psychoeducation (SRP) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05925322?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05925322 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05925322's enrollment target sits among peer trials
128 288th of 679 higher than 391 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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