Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 2 of 14
Positive Affect Treatment for Adolescents with Early Life Adversity
University of California, Irvine
NCT06273137
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults
University of North Carolina, Chapel Hill
NCT06060860
To Improve Depressive Symptoms Using a Web-App
University of Texas at Austin
NCT05405803
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Indiana University
NCT06627894
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
VA Office of Research and Development
NCT06162741
Lay-Delivered Behavioral Activation in Senior Centers
University of Washington
NCT04621877
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
University of Miami
NCT05453513
Neural and Psychiatric Consequences of Cannabis Use in Adolescents
University of Miami
NCT06941298
IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
Medical University of South Carolina
NCT06582784
Suubi-Mhealth: A Mobile Health Intervention to Address Depression Among Youth
Washington University School of Medicine
NCT05965245
Wellness App for Sleep Disturbance in Hematological Cancer Patients
The University of Texas Health Science Center at San Antonio
NCT05294991
MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression
VA Office of Research and Development
NCT05220202
Brain Connectivity in Depression
Brigham and Women's Hospital
NCT03276793
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
University of Minnesota
NCT05117255
Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
University of Michigan
NCT06584422
Telehealth Behavioral Activation for Teens
Baylor College of Medicine
NCT06273995
Evaluation of the H.O.O.V.E.S. Healing Intensives Program
VA Salt Lake City Health Care System
NCT06300255
M-O-M-S on the Bayou: Implementation of an Intervention for Mental Health in Pregnancy
Tulane University
NCT05838404
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
University of Alabama at Birmingham
NCT05437588
Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
University of California, Los Angeles
NCT05908565
fMRI Neurofeedback With Matter Neuroscience App
Stanford University
NCT06735885
Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches
Veterans Medical Research Foundation
NCT05176392
Conversations With Caregivers About Health and Appearance
University of Oregon
NCT06843200
Digital Single Session Intervention for Youth Mental Health
Harvard University
NCT05449002
Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome (AAC-BeT)
Laureate Institute for Brain Research
NCT04426461
Testing a Lifestyle Physical Activity Intervention for Women With Depression in Alcohol Treatment
Butler Hospital
NCT04667520
Testing FIRST in Youth Outpatient Psychotherapy
Harvard University
NCT04725721
Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit
East Carolina University
NCT07173205
An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression
Singula Institute
NCT05466851
Well-being Training for Adolescent Depressive Symptoms (TeenWell Study)
University of Wisconsin, Madison
NCT06626425
Mindful Moms Randomized Control Trial
Virginia Commonwealth University
NCT04886856
Cerebellar Stimulation and Cognitive Control
Krystal Parker, PhD
NCT03217110
Neonatal Neurodevelopmental Outcomes
Baylor College of Medicine
NCT07101757
Cannabis, Linked Emotions, and Adolescent Risk Study
Massachusetts General Hospital
NCT06576076
Collaborative Care for Treatment of Depression and Anxiety
Kaiser Permanente
NCT06556589
Project neuroARTEMIS
Wake Forest University Health Sciences
NCT06814275
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT05474846
Cannabis for Palliative Care in Cancer
University of Colorado, Boulder
NCT06266611
Brief Interventions for Coping with Distress
Teachers College, Columbia University
NCT05779761
Parent Encouragement And Coaching of Happiness in Youth
University of Pittsburgh
NCT06725160
Family Acceptance Project Online (Pilot RCT)
University of Michigan
NCT06839859
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
NYU Langone Health
NCT06901687
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
Laureate Institute for Brain Research
NCT06004115
Cold and Heat Investigation to Lower Levels of Depression
Barry Sandler
NCT06263738
ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression
Stanford University
NCT06408246
Safe Mothers, Safe Children Initiative
New York University
NCT04752618
Early Life Stress and Depression: Molecular and Functional Imaging
Mclean Hospital
NCT04713722
The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program
Nova Southeastern University
NCT06652503
A Computerized Depression Intervention in Veterans
VA Office of Research and Development
NCT06217198
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.