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NCT06269146 · ClinicalTrials.gov registry record · Phase 2
Pramipexole to Enhance Social Connections
A Phase 2 study of Depression and Anxiety, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 108
- Enrollment target
- 2
- Study locations
NCT06269146 is a Phase 2 study of Depression and Anxiety that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 108 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (86% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT06269146, a Phase 2 study of Depression and Anxiety, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 108 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of California San Diego and New York State Psychiatric Institute). Pramipexole will be given in a 6-week randomized, double-blind, placebo-controlled trial. Social reward processing will be assessed using measures of brain function (fMRI), behavior, and self-report at baseline and week 6. Knowledge gained from this study will help determine the therapeutic potential of targeting the dopamine system to remediate social disconnection as an anxiety and depression intervention.
Conditions Studied
Interventions
- DRUG Pramipexole Pill
- DRUG Placebo Pill
Study Locations (2)
California
- University of California, San Diego - San Diego
New York
- New York State Psychiatric Institute - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 108 participants |
| Start Date | 2024-05-13 |
| Est. Completion | 2026-03 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06269146
The ClinicalTrials.gov registry entry for NCT06269146 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 108 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (86% lower). The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Pramipexole Pill is the first listed.
NCT06269146 reports 2 study locations spanning 2 distinct geographic areas - top geographies include California, New York.
Frequently Asked Questions
What is clinical trial NCT06269146 about?
NCT06269146 is a clinical study titled "Pramipexole to Enhance Social Connections". This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of California San Diego and New York State Psychiatric...
What is the current status of trial NCT06269146?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 108 participants. The study started on 2024-05-13. Estimated completion is 2026-03.
What conditions does trial NCT06269146 study?
This clinical trial studies the following conditions: Depression, Anxiety, Anxiety Disorders, Social Disconnection.
What interventions are being tested in trial NCT06269146?
The interventions under investigation include: Pramipexole Pill (DRUG), Placebo Pill (DRUG).
Who is sponsoring clinical trial NCT06269146?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06269146 being conducted?
This trial has 2 study locations across California, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.