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NCT05548244 · ClinicalTrials.gov registry record · NA
Mechanisms of Behavioral Activation (BA)
A NA study of Depression, sponsored by Emory University.
- Recruiting
- Registry status
- NA
- Development phase
- 136
- Enrollment target
- 3
- Study locations
NCT05548244: Recruiting NA study of Depression, sponsored by Emory University.
NCT05548244 is a NA study of Depression that is actively recruiting participants, run by Emory University. The registered enrollment target is 136 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (83% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05548244, a NA study of Depression, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- NA
- Development phase
- 136 participants
- Enrollment target
- 3
- Study locations
Study Summary
The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural mechanisms for behavioral avoidance associated with low motivation as compared to threat avoidance. A group of healthy controls will also be scanned as a comparator group for behavioral and imaging measures.
Primary Outcome
Change from baseline on the Children's Depression Rating Scale-Revised (CDRS-R) total score. CDRS-R Total score measures the presence and severity of depression in children. The scale consists of 17 items scored on a 1-to-5- or 1-to-7-point scale. A rating of 1 indicates normal functioning and a higher number indicates a greater degree of depression. The total sum of scores range from 17 to 113. Following on prior studies of adolescent MDD, a diagnosis of MDD and a CDRS-R score of 45 or greater
Conditions Studied
Interventions
- BEHAVIORAL Behavioral Activation Therapy
- BEHAVIORAL Baseline assessment procedures
Study Locations (3)
Georgia
- Emory University - Atlanta
- Facility for Education and Research in Neuroscience (FERN) - Atlanta
- Child and Adolescent Mood Program (CAMP) - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 136 participants |
| Start Date | 2023-01-30 |
| Est. Completion | 2027-05 |
| Phase | NA |
What NCT05548244 shows while recruiting
NCT05548244 is an interventional study that assigns participants to a tested intervention. The registered 136 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (83% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Behavioral Activation Therapy is the first listed.
NCT05548244 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT05548244 about?
NCT05548244 is a clinical study titled "Mechanisms of Behavioral Activation (BA)". The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonance imaging (fMRI). In particular, the project seeks to determine whether BA targets different neural...
What is the current status of trial NCT05548244?
This trial is currently recruiting. It is a NA study. The enrollment target is 136 participants. The study started on 2023-01-30. Estimated completion is 2027-05.
What conditions does trial NCT05548244 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT05548244?
The interventions under investigation include: Behavioral Activation Therapy (BEHAVIORAL), Baseline assessment procedures (BEHAVIORAL).
Who is sponsoring clinical trial NCT05548244?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05548244 being conducted?
This trial has 3 study locations across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05548244's enrollment target sits among peer trials
136 275th of 679 higher than 404 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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