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NCT06408246 · ClinicalTrials.gov registry record · Phase 2

ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

A Phase 2 study of Depression, sponsored by Stanford University.

Recruiting
Registry status
Phase 2
Development phase
162
Enrollment target
2
Study locations

NCT06408246: Recruiting Phase 2 study of Depression, sponsored by Stanford University.

NCT06408246 is a Phase 2 study of Depression that is actively recruiting participants, run by Stanford University. The registered enrollment target is 162 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (79% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06408246, a Phase 2 study of Depression, is actively recruiting participants, sponsored by Stanford University.

RECRUITING
Registry status
Phase 2
Development phase
162 participants
Enrollment target
2
Study locations

Study Summary

The purpose of this study is to understand how a psychotropic medication called guanfacine affects brain network functioning in humans, and how this function interacts with cognitive impairments in people experiencing depressive symptoms.

Conditions Studied

Depression

Interventions

  • DRUG Guanfacine
  • DRUG Sertraline

Study Locations (2)

California

  • Stanford Psychiatry and Behavioral Sciences Department - Palo Alto

Illinois

  • University of Illinois at Chicago - Chicago

Trial Details

FieldValue
Enrollment Target 162 participants
Start Date 2026-03-03
Est. Completion 2029-02-01
Phase Phase 2

Sponsor

Stanford University

1,744 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06408246

The ClinicalTrials.gov registry entry for NCT06408246 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 162 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (79% lower). The listed sponsor is Stanford University, which has 1,744 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Guanfacine is the first listed.

NCT06408246 reports 2 study locations spanning 2 distinct geographic areas - top geographies include California, Illinois.

Frequently Asked Questions

What is clinical trial NCT06408246 about?

NCT06408246 is a clinical study titled "ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression". The purpose of this study is to understand how a psychotropic medication called guanfacine affects brain network functioning in humans, and how this function interacts with cognitive impairments in people experiencing depressive symptoms.

What is the current status of trial NCT06408246?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 162 participants. The study started on 2026-03-03. Estimated completion is 2029-02-01.

What conditions does trial NCT06408246 study?

This clinical trial studies the following conditions: Depression.

What interventions are being tested in trial NCT06408246?

The interventions under investigation include: Guanfacine (DRUG), Sertraline (DRUG).

Who is sponsoring clinical trial NCT06408246?

This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06408246 being conducted?

This trial has 2 study locations across California, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Read our methodology - how this data is sourced, computed, and verified.
Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.