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NCT06273137 · ClinicalTrials.gov registry record · NA
Positive Affect Treatment for Adolescents with Early Life Adversity
A NA study of Depression, sponsored by University of California, Irvine.
- Recruiting
- Registry status
- NA
- Development phase
- 300
- Enrollment target
- 1
- Study location
NCT06273137 is a NA study of Depression that is actively recruiting participants, run by University of California, Irvine. The registered enrollment target is 300 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (62% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06273137, a NA study of Depression, is actively recruiting participants, sponsored by University of California, Irvine.
- RECRUITING
- Registry status
- NA
- Development phase
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For the initial pilot phase of the investigation, the investigators will recruit up to 30 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or a waitlist control condition. For the second phase of the investigation, the investigators will recruit up to 300 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or supportive psychotherapy. For both phases, at study enrollment, then 4-, 8, and 12-months thereafter the investigators will measure positive affect and depressive symptoms (including anhedonia and reward sensitivity). The results of this study will be used to inform whether PAT has the potential to prevent major depressive episodes among adversity-exposed youth.
Conditions Studied
Interventions
- BEHAVIORAL Positive affect treatment
- BEHAVIORAL Supportive psychotherapy (SUP)
Study Locations (1)
California
- University of California Irvine - Irvine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2024-02-03 |
| Est. Completion | 2030-10-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06273137
The ClinicalTrials.gov registry entry for NCT06273137 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (62% lower). The listed sponsor is University of California, Irvine, which has 368 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Positive affect treatment is the first listed.
NCT06273137 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06273137 about?
NCT06273137 is a clinical study titled "Positive Affect Treatment for Adolescents with Early Life Adversity". Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The p...
What is the current status of trial NCT06273137?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2024-02-03. Estimated completion is 2030-10-31.
What conditions does trial NCT06273137 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT06273137?
The interventions under investigation include: Positive affect treatment (BEHAVIORAL), Supportive psychotherapy (SUP) (BEHAVIORAL).
Who is sponsoring clinical trial NCT06273137?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06273137 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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