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NCT05453513 · ClinicalTrials.gov registry record · NA
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
A NA study of Depression and HIV, sponsored by University of Miami.
- Recruiting
- Registry status
- NA
- Development phase
- 280
- Enrollment target
- 1
- Study location
NCT05453513: Recruiting NA study of Depression and HIV, sponsored by University of Miami.
NCT05453513 is a NA study of Depression and HIV that is actively recruiting participants, run by University of Miami. The registered enrollment target is 280 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (64% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05453513, a NA study of Depression and HIV, is actively recruiting participants, sponsored by University of Miami.
- RECRUITING
- Registry status
- NA
- Development phase
- 280 participants
- Enrollment target
- 1
- Study location
Study Summary
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up.
Primary Outcome
The number of days using illicit opioids in the past 30 days per self-report as collected through the Addiction Severity Index.
Conditions Studied
Interventions
- BEHAVIORAL MRI Study
Study Locations (1)
Florida
- University of Miami - Miami
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 280 participants |
| Start Date | 2022-04-01 |
| Est. Completion | 2027-07-30 |
| Phase | NA |
What NCT05453513 shows while recruiting
NCT05453513 is an interventional study that assigns participants to a tested intervention. The registered 280 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (64% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which MRI Study is the first listed.
NCT05453513 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT05453513 about?
NCT05453513 is a clinical study titled "The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV". To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightl...
What is the current status of trial NCT05453513?
This trial is currently recruiting. It is a NA study. The enrollment target is 280 participants. The study started on 2022-04-01. Estimated completion is 2027-07-30.
What conditions does trial NCT05453513 study?
This clinical trial studies the following conditions: Depression, HIV, Cannabis Use Disorder.
What interventions are being tested in trial NCT05453513?
The interventions under investigation include: MRI Study (BEHAVIORAL).
Who is sponsoring clinical trial NCT05453513?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05453513 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05453513's enrollment target sits among peer trials
280 158th of 679 higher than 521 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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