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NCT04725721 · ClinicalTrials.gov registry record · NA
Testing FIRST in Youth Outpatient Psychotherapy
A NA study of Depression and Anxiety, sponsored by Harvard University.
- Recruiting
- Registry status
- NA
- Development phase
- 212
- Enrollment target
- 2
- Study locations
NCT04725721: Recruiting NA study of Depression and Anxiety, sponsored by Harvard University.
NCT04725721 is a NA study of Depression and Anxiety that is actively recruiting participants, run by Harvard University. The registered enrollment target is 212 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (73% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04725721, a NA study of Depression and Anxiety, is actively recruiting participants, sponsored by Harvard University.
- RECRUITING
- Registry status
- NA
- Development phase
- 212 participants
- Enrollment target
- 2
- Study locations
Study Summary
The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.
Primary Outcome
The CBCL is a parent-report checklist with 113 youth problem items, each rated on a 0-1-2 scale (0 = not true, 1 = somewhat/sometimes true, 2 = very often true). The YSR is a corresponding 112-item youth-report checklist measure. From both the CBCL and the YSR, T-scores, adjusted for age and gender, Internalizing, Externalizing, and Total Problems scales will be used for outcome assessment. Higher scores represent more severe problems, with borderline and clinical cutoffs at T = 60 and T = 63, r
Conditions Studied
Interventions
- BEHAVIORAL Usual Care
- BEHAVIORAL FIRST
Study Locations (2)
Massachusetts
- Harvard University - Cambridge
Texas
- University of Texas at Austin - Austin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 212 participants |
| Start Date | 2021-09-27 |
| Est. Completion | 2026-02 |
| Phase | NA |
What NCT04725721 shows while recruiting
NCT04725721 is an interventional study that assigns participants to a tested intervention. The registered 212 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (73% lower).
The record links to 4 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Usual Care is the first listed.
NCT04725721 reports a single indexed study location in Massachusetts, Texas.
Frequently Asked Questions
What is clinical trial NCT04725721 about?
NCT04725721 is a clinical study titled "Testing FIRST in Youth Outpatient Psychotherapy". The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.
What is the current status of trial NCT04725721?
This trial is currently recruiting. It is a NA study. The enrollment target is 212 participants. The study started on 2021-09-27. Estimated completion is 2026-02.
What conditions does trial NCT04725721 study?
This clinical trial studies the following conditions: Depression, Anxiety, Trauma, Behavior Problem.
What interventions are being tested in trial NCT04725721?
The interventions under investigation include: Usual Care (BEHAVIORAL), FIRST (BEHAVIORAL).
Who is sponsoring clinical trial NCT04725721?
This trial is sponsored by Harvard University, which has 37 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04725721 being conducted?
This trial has 2 study locations across Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04725721's enrollment target sits among peer trials
212 200th of 679 higher than 480 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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