Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 56 recruiting now official registry

COVID-19 clinical trials

56 of 204 indexed COVID-19 trials are currently recruiting.

204 US clinical trials · 56 currently recruiting

COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.

The research picture

COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.

56
recruiting participants now
27%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
15
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 118Phase 242Phase 321Phase 49

Active & Recent Trials

204 total, page 3 of 5

ACTIVE NOT RECRUITING 1 participants

Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data

Pfizer

NCT05876377

COMPLETED NA 520,000 participants

Message From Local Pharmacy Team

University of Pennsylvania

NCT05613764

COMPLETED Phase 2 47,079 participants

Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals

BioNTech SE

NCT04368728

COMPLETED Phase 3 32,450 participants

Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults

AstraZeneca

NCT04516746

COMPLETED 18,157 participants

Wearable Assisted Viral Evidence (WAVE) Study A Decentralized, Prospective Study Exploring the Relationship Between Passively-collected Data From Wearable Activity Devices and Respiratory Viral Infections

Evidation Health

NCT06207929

COMPLETED 17,318 participants

International Registry of Coronavirus (COVID-19) Exposure in Pregnancy

Pregistry

NCT04366986

COMPLETED NA 16,903 participants

Impact of Nudges on Downloads of COVID-19 Exposure Notification Smartphone Apps: A Randomized Trial

University of Pennsylvania

NCT05080179

COMPLETED Phase 3 14,246 participants

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

ModernaTX

NCT05815498

COMPLETED 6,894 participants

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Pregistry

NCT04385238

COMPLETED 2,824 participants

Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)

VA Office of Research and Development

NCT05764083

COMPLETED 2,300 participants

Respiratory Supports and COVID-19 Mortality

Yale University

NCT04832061

COMPLETED NA 2,093 participants

Can Vitamin D Reduce the Burden of COVID-19?

University of Chicago

NCT07128069

COMPLETED Phase 2 2,091 participants

EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19

Pfizer

NCT04960202

COMPLETED NA 1,971 participants

Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19

University of California, Los Angeles

NCT04373135

COMPLETED Phase 2 1,912 participants

Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19

Regeneron Pharmaceuticals

NCT04315298

COMPLETED Phase 2 1,755 participants

A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness

Eli Lilly and Company

NCT04634409

COMPLETED 1,442 participants

Methodologies for Observational Studies Comparing Inpatient COVID-19 Treatments

Aetion

NCT05638932

COMPLETED Phase 2 1,380 participants

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

BioNTech SE

NCT05004181

COMPLETED NA 1,271 participants

COVID-19 Self-testing IMPROVE

Temple University

NCT06576167

COMPLETED NA 1,232 participants

Examining How a Facilitated Self-Sampling Intervention and Testing Navigation Intervention Influences COVID-19 Testing

The University of Texas Health Science Center, Houston

NCT05606016

COMPLETED Phase 3 1,180 participants

A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff

Eli Lilly and Company

NCT04497987

COMPLETED Phase 2 1,051 participants

A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals

BioNTech SE

NCT05997290

COMPLETED NA 1,029 participants

The Safer At School Early Alert HUB

University of California, San Diego

NCT05642000

COMPLETED Phase 2 1,019 participants

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Modified RNA Vaccine Candidates Against COVID-19 and Influenza

BioNTech SE

NCT05596734

COMPLETED Phase 3 1,010 participants

Adaptive COVID-19 Treatment Trial 4 (ACTT-4)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04640168

COMPLETED Phase 3 969 participants

Adaptive COVID-19 Treatment Trial 3 (ACTT-3)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04492475

COMPLETED Phase 3 935 participants

Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19

Romark Laboratories L.C.

NCT04486313

COMPLETED 825 participants

COVID-19 Quantitative Antibody Titers & Booster Vaccinations

Epividian

NCT05104359

COMPLETED 803 participants

Social Determinants of Health in Patients With Penetrating Trauma Injuries Before and During the COVID-19 Pandemic

Kern Medical Center

NCT06135610

COMPLETED Phase 2 746 participants

COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04761822

COMPLETED Phase 2 660 participants

A Study to Evaluate the Safety and Immunogenicity of an (Omicron Subvariant) COVID-19 Vaccine Booster Dose in Previously Vaccinated Participants and Unvaccinated Participants.

Novavax

NCT05975060

COMPLETED NA 616 participants

Getting INFORMED and Living Well Among Asian Americans in California

University of California, San Francisco

NCT05968300

COMPLETED 602 participants

Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling

Duke University

NCT04437706

COMPLETED Phase 3 593 participants

Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)

University of Minnesota

NCT04546581

COMPLETED NA 554 participants

COVID-19 Treatment Cascade Optimization Study

University of Illinois at Urbana-Champaign

NCT05305443

COMPLETED NA 508 participants

Discussing COVID-19 Vaccines in Private Facebook Groups

George Washington University

NCT05422898

COMPLETED NA 498 participants

Leveraging Social Networks to Increase COVID-19 Testing Uptake

New York State Psychiatric Institute

NCT04873401

COMPLETED Phase 3 485 participants

MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05780463

COMPLETED 472 participants

Monitoring Serologic Response to Severe Acute Respiratory Syndrome-2 (SARS-COV-2)/COVID-19 in Children

Connecticut Children's Medical Center

NCT04838834

COMPLETED 456 participants

Saliva as Source of Detection for SARS-CoV-2

National Institutes of Health Clinical Center (CC)

NCT04424446

COMPLETED 450 participants

Prophylaxis and Treatment of COVID-19

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT04844541

COMPLETED NA 447 participants

Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Panel

Abbott Rapid Dx

NCT06127108

COMPLETED 412 participants

COVID-19 in Patients With HIV

University of Missouri-Columbia

NCT04333953

COMPLETED Phase 3 400 participants

A Study of the Safety and Efficacy of Ciclesonide in the Treatment of Non-hospitalized COVID-19 Patients

Covis Pharma S.à.r.l.

NCT04377711

COMPLETED Phase 3 367 participants

VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05780281

COMPLETED 367 participants

suPAR Michigan M2C2 Heterogeneity Validation Cohort Study

ViroGates A/S

NCT07466524

COMPLETED 342 participants

COVID-19 Infection in Patients Receiving Anti-CD20 Therapy

Mayo Clinic

NCT04884477

COMPLETED 336 participants

Audio Data Collection for Identification and Classification of Coughing

HealthMode

NCT04326309

COMPLETED NA 330 participants

Evaluation of the RD-X19 Treatment Device in Individuals With Mild COVID-19

EmitBio

NCT05817045

COMPLETED NA 300 participants

Seroprevalence of SARS CoV 2 Antibodies in Previously Undiagnosed Healthcare Workers

Mayo Clinic

NCT04383587

← Previous Page 3 of 5 Next →

Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 42
Phase 3 21
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COVID-19 Trial Landscape

204 indexed COVID-19 studies · 56 recruiting (27%).

Phase mix: 30 late (III/IV) vs 60 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COVID-19?

PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COVID-19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.