Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
COVID-19 clinical trials
56 of 204 indexed COVID-19 trials are currently recruiting.
204 US clinical trials · 56 currently recruiting
COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.
The research picture
COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.
- 56
- recruiting participants now
- 27%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 15
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
204 total, page 3 of 5
Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data
Pfizer
NCT05876377
Message From Local Pharmacy Team
University of Pennsylvania
NCT05613764
Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
BioNTech SE
NCT04368728
Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults
AstraZeneca
NCT04516746
Wearable Assisted Viral Evidence (WAVE) Study A Decentralized, Prospective Study Exploring the Relationship Between Passively-collected Data From Wearable Activity Devices and Respiratory Viral Infections
Evidation Health
NCT06207929
International Registry of Coronavirus (COVID-19) Exposure in Pregnancy
Pregistry
NCT04366986
Impact of Nudges on Downloads of COVID-19 Exposure Notification Smartphone Apps: A Randomized Trial
University of Pennsylvania
NCT05080179
A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19
ModernaTX
NCT05815498
Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
Pregistry
NCT04385238
Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)
VA Office of Research and Development
NCT05764083
Respiratory Supports and COVID-19 Mortality
Yale University
NCT04832061
Can Vitamin D Reduce the Burden of COVID-19?
University of Chicago
NCT07128069
EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19
Pfizer
NCT04960202
Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19
University of California, Los Angeles
NCT04373135
Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19
Regeneron Pharmaceuticals
NCT04315298
A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness
Eli Lilly and Company
NCT04634409
Methodologies for Observational Studies Comparing Inpatient COVID-19 Treatments
Aetion
NCT05638932
Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants
BioNTech SE
NCT05004181
COVID-19 Self-testing IMPROVE
Temple University
NCT06576167
Examining How a Facilitated Self-Sampling Intervention and Testing Navigation Intervention Influences COVID-19 Testing
The University of Texas Health Science Center, Houston
NCT05606016
A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff
Eli Lilly and Company
NCT04497987
A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals
BioNTech SE
NCT05997290
The Safer At School Early Alert HUB
University of California, San Diego
NCT05642000
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Modified RNA Vaccine Candidates Against COVID-19 and Influenza
BioNTech SE
NCT05596734
Adaptive COVID-19 Treatment Trial 4 (ACTT-4)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04640168
Adaptive COVID-19 Treatment Trial 3 (ACTT-3)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04492475
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
Romark Laboratories L.C.
NCT04486313
COVID-19 Quantitative Antibody Titers & Booster Vaccinations
Epividian
NCT05104359
Social Determinants of Health in Patients With Penetrating Trauma Injuries Before and During the COVID-19 Pandemic
Kern Medical Center
NCT06135610
COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04761822
A Study to Evaluate the Safety and Immunogenicity of an (Omicron Subvariant) COVID-19 Vaccine Booster Dose in Previously Vaccinated Participants and Unvaccinated Participants.
Novavax
NCT05975060
Getting INFORMED and Living Well Among Asian Americans in California
University of California, San Francisco
NCT05968300
Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling
Duke University
NCT04437706
Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)
University of Minnesota
NCT04546581
COVID-19 Treatment Cascade Optimization Study
University of Illinois at Urbana-Champaign
NCT05305443
Discussing COVID-19 Vaccines in Private Facebook Groups
George Washington University
NCT05422898
Leveraging Social Networks to Increase COVID-19 Testing Uptake
New York State Psychiatric Institute
NCT04873401
MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05780463
Monitoring Serologic Response to Severe Acute Respiratory Syndrome-2 (SARS-COV-2)/COVID-19 in Children
Connecticut Children's Medical Center
NCT04838834
Saliva as Source of Detection for SARS-CoV-2
National Institutes of Health Clinical Center (CC)
NCT04424446
Prophylaxis and Treatment of COVID-19
Henry M. Jackson Foundation for the Advancement of Military Medicine
NCT04844541
Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Panel
Abbott Rapid Dx
NCT06127108
COVID-19 in Patients With HIV
University of Missouri-Columbia
NCT04333953
A Study of the Safety and Efficacy of Ciclesonide in the Treatment of Non-hospitalized COVID-19 Patients
Covis Pharma S.à.r.l.
NCT04377711
VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05780281
suPAR Michigan M2C2 Heterogeneity Validation Cohort Study
ViroGates A/S
NCT07466524
COVID-19 Infection in Patients Receiving Anti-CD20 Therapy
Mayo Clinic
NCT04884477
Audio Data Collection for Identification and Classification of Coughing
HealthMode
NCT04326309
Evaluation of the RD-X19 Treatment Device in Individuals With Mild COVID-19
EmitBio
NCT05817045
Seroprevalence of SARS CoV 2 Antibodies in Previously Undiagnosed Healthcare Workers
Mayo Clinic
NCT04383587
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 42 |
| Phase 3 | 21 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COVID-19 Trial Landscape
204 indexed COVID-19 studies · 56 recruiting (27%).
Phase mix: 30 late (III/IV) vs 60 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COVID-19?
PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COVID-19?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.