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NCT07183709 · ClinicalTrials.gov registry record · Phase 1
Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults
A Phase 1 study of COVID-19, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Active
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
- 3
- Study locations
NCT07183709 is a Phase 1 study of COVID-19 that is active but no longer recruiting, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 30 participants, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT07183709, a Phase 1 study of COVID-19, is active but no longer recruiting, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
- 3
- Study locations
Study Summary
This Phase 1 clinical trial will evaluate the safety, reactogenicity, and immunogenicity of PepGNP-COVID19, a synthetic nanoparticle-based, T cell-priming peptide vaccine against SARS-CoV-2, when administered as a booster dose in healthy adults. PepGNP-COVID19 is designed to induce broad and durable T cell-mediated immune responses by delivering conserved SARS-CoV-2 peptides covalently bound to carbohydrate-coated gold nanoparticles, with the goal of enhancing tissue-resident cytotoxic T lymphocytes in the respiratory tract and reducing the need for frequent antigen updates. This randomized, participant-blinded, dose-ranging, multi-site trial will enroll 60 healthy adults aged 18-64 years, with a target of 8 of 20 participants in each cohort being \> / = 50 years of age. Participants will receive a single intradermal injection of PepGNP-COVID19 at one of three dosage levels (0.83 nmol, 2.5 nmol, or 7.5 nmol in a volume of 0.05 mL). The primary objective is to evaluate the safety, reactogenicity, and tolerability of a single intradermal dose of PepGNP-COVID19 at three dosage levels in previously vaccinated healthy adults.
Conditions Studied
Interventions
- BIOLOGICAL PepGNP-COVID19
- OTHER Sterile Water for Injection
Study Locations (3)
Alabama
- University of Alabama at Birmingham School of Medicine - Infectious Disease - Birmingham
District of Columbia
- George Washington University Medical Faculty Associates - Washington D.C.
Ohio
- Cincinnati Children's Hospital Medical Center Vaccine Research Center - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-02-02 |
| Est. Completion | 2026-08-03 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07183709
The ClinicalTrials.gov registry entry for NCT07183709 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 2 interventions - of which PepGNP-COVID19 is the first listed.
NCT07183709 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Alabama, District of Columbia, Ohio.
Frequently Asked Questions
What is clinical trial NCT07183709 about?
NCT07183709 is a clinical study titled "Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults". This Phase 1 clinical trial will evaluate the safety, reactogenicity, and immunogenicity of PepGNP-COVID19, a synthetic nanoparticle-based, T cell-priming peptide vaccine against SARS-CoV-2, when administered as a booster dose in healthy adults. PepGNP-COVID19 is designed to induce broad and durable...
What is the current status of trial NCT07183709?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2026-02-02. Estimated completion is 2026-08-03.
What conditions does trial NCT07183709 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT07183709?
The interventions under investigation include: PepGNP-COVID19 (BIOLOGICAL), Sterile Water for Injection (OTHER).
Who is sponsoring clinical trial NCT07183709?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07183709 being conducted?
This trial has 3 study locations across Alabama, District of Columbia, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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