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NCT04832061 · ClinicalTrials.gov registry record
Respiratory Supports and COVID-19 Mortality
A clinical trial of COVID-19, sponsored by Yale University.
- Completed
- Registry status
- 2,300
- Enrollment target
- 1
- Study location
NCT04832061: Completed study of COVID-19, sponsored by Yale University.
NCT04832061 is a study of COVID-19 that has completed, run by Yale University. The registered enrollment target is 2,300 participants, below the 38,457-participant average among 298 other COVID-19 trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04832061, a study of COVID-19, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- 2,300 participants
- Enrollment target
- 1
- Study location
Study Summary
Critically ill COVID-19 patients have a relatively high mortality rate (\~30%). Most critically ill COVID-19 patients require respiratory supports. The respiratory supports used in this patient population included conventional oxygen therapy (COT) via nasal cannula or face mask, non-invasive ventilation (NIV), and invasive mechanical ventilation (IMV). NIV has three different methods, including high-flow nasal cannula (HFNC), bilevel positive airway pressure (BiPAP), and continuous positive airway pressure (CPAP). There are outstanding questions that remain to be answered. One is which NIV is more effective; the other is if the use of IMV leads to increased mortality. Another relevant question is if ventilator settings (such as tidal volume, drive pressure, and positive end-expiratory pressure) are associated with different mechanical ventilated patients' outcomes. To answer these questions, a retrospective cohort study based on all patients who had been treated in the ICUs in Yale New Haven Health System throughout the first pandemic year was designed.
Primary Outcome
the number of all-cause death during hospitalization divided by the number of patients who were discharged from hospital or remained hospitalized but alive on the last day of data extraction
Conditions Studied
Interventions
- OTHER Respiratory supports
Study Locations (1)
Connecticut
- Yale University School of Medicine - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,300 participants |
| Start Date | 2021-04-01 |
| Est. Completion | 2021-04-20 |
What the finished NCT04832061 record still lists
NCT04832061 is an observational study that tracks outcomes without assigning an intervention. Its 2,300 participants enrollment target places it among the larger protocols in the corpus, below the 38,457-participant average among 298 other COVID-19 trials with a reported enrollment target (94% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 1 intervention - of which Respiratory supports is the first listed.
NCT04832061 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT04832061 about?
NCT04832061 is a clinical study titled "Respiratory Supports and COVID-19 Mortality". Critically ill COVID-19 patients have a relatively high mortality rate (\~30%). Most critically ill COVID-19 patients require respiratory supports. The respiratory supports used in this patient population included conventional oxygen therapy (COT) via nasal cannula or face mask, non-invasive ventila...
What is the current status of trial NCT04832061?
This trial is currently completed. The enrollment target is 2,300 participants. The study started on 2021-04-01. Estimated completion is 2021-04-20.
What conditions does trial NCT04832061 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT04832061?
The interventions under investigation include: Respiratory supports (OTHER).
Who is sponsoring clinical trial NCT04832061?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04832061 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for COVID-19
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04832061's enrollment target sits among peer trials
2,300 41st of 298 higher than 258 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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