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COVID-19 clinical trials
56 of 204 indexed COVID-19 trials are currently recruiting.
204 US clinical trials · 56 currently recruiting
COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.
The research picture
COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.
- 56
- recruiting participants now
- 27%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 15
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
204 total, page 2 of 5
Evaluating the Impact of Social Music
Yale University
NCT06513910
A Nasal Treatment for COVID-19
Indiana University
NCT05799521
A Study of Healthy Microbiome, Healthy Mind
Mayo Clinic
NCT06020703
Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise
Ohio State University Comprehensive Cancer Center
NCT04427566
Arginine Replacement Therapy in COVID-19
Emory University
NCT05855330
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
University of California, San Francisco
NCT05530317
COVID-19 Symptom Tracker
King's College London
NCT04331509
Duke COVID-19 Shared Data and Specimen Repository
Duke University
NCT04368234
A Study to Learn How Paxlovid [Nirmatrelvir-ritonavir/PF-07321332] Works in COVID-19 Patients Who Are Elderly or Have Medical Conditions.
Pfizer
NCT07261085
COVID-19 & Psychiatry: A Retrospective Chart Review
Northwestern University
NCT05244096
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
AgileMD
NCT05893420
COVID-19 and Cancer Consortium Registry
Vanderbilt-Ingram Cancer Center
NCT04354701
A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection
Vaxart
NCT06672055
Project REMOTE (REimagining Measurements and Operations of Translational Endpoints)
Biomedical Advanced Research and Development Authority
NCT06776367
Study to Evaluate Safety and Immunogenicity of COVID-19 Vaccine in Children 6 Months to < 12 Years
Novavax
NCT05468736
Retail COVID-19 Study
Biomedical Advanced Research and Development Authority
NCT06761612
COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers
Villanova University
NCT04370821
Study of VYD2311 for the Prevention of COVID-19
Invivyd
NCT07298434
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
QuantumLeap Healthcare Collaborative
NCT04488081
COVID-19 Reactogenicity
Marcel Curlin
NCT07051031
COVID-19 Quick Start - Test and Treat in Africa
Duke University
NCT06360783
A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza
Pfizer
NCT05160636
Engaging Staff to Improve COVID-19 Vaccination Response at Long-Term Care Facilities
Kaiser Permanente
NCT05449418
A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years
BioNTech SE
NCT07069309
Safety and Immunogenicity of NVX-CoV2705
Sanofi
NCT07079670
Impact of Reactogenicity of the 2024-2025 COVID-19 Vaccines on Health Care Workers and First Responders in the United States
Novavax
NCT06633835
A Longitudinal Study of COVID-19 Sequelae and Immunity
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04411147
Long Term Outcomes of Patients With COVID-19
University of Chicago
NCT04360538
A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults
CyanVac
NCT06742281
Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement
University of California, San Diego
NCT05841810
ARMOR-Household: Characterizing Transmission of COVID-19 in Households of SARS-CoV-2 Index Cases
Columbia University
NCT05467917
A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That Are Considered at Higher Risk of Severe COVID-19
BioNTech SE
NCT07222384
SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies
The Geneva Foundation
NCT05765396
A Phase 2 Trial of the Immunogenicity and Safety of CVXGA Intranasal COVID Vaccine in Healthy Adults
CyanVac
NCT05736835
COVID-19 Biorepository
University of Kansas Medical Center
NCT04568148
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
The University of Texas Medical Branch, Galveston
NCT05815485
Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection
Medical University of South Carolina
NCT04482673
Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans
National Institute on Aging (NIA)
NCT04565067
Impact of Lp299v on Vascular Function in Patients With PASC
Medical College of Wisconsin
NCT05227170
Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET)
Ohio State University
NCT05881135
A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans
National Institute on Aging (NIA)
NCT04852289
A First in Human Study to Evaluate the Safety and Immunogenicity of RBM-001 in Healthy Adult Volunteers
Rock BioMedical
NCT06878170
Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases
Northwestern University
NCT05822219
Safety, Reactogenicity, and Immunogenicity Trial of STX-S SARS-CoV-2 Vaccine in Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07095231
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19
Northwell Health
NCT04724720
COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE)
National Institutes of Health Clinical Center (CC)
NCT04595773
A Study of N-acetylcysteine in Patients With COVID-19 Infection
Memorial Sloan Kettering Cancer Center
NCT04374461
Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia
Ohio State University Comprehensive Cancer Center
NCT04466683
Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT07183709
A Study to Learn About How Well Yearly Updates to the COVID-19 Vaccine Work to Protect People From COVID-19 and How Much Money People Spend on Healthcare for COVID-19
Pfizer
NCT06923137
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 42 |
| Phase 3 | 21 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COVID-19 Trial Landscape
204 indexed COVID-19 studies · 56 recruiting (27%).
Phase mix: 30 late (III/IV) vs 60 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COVID-19?
PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COVID-19?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.