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ClinicalTrials.gov 56 recruiting now official registry

COVID-19 clinical trials

56 of 204 indexed COVID-19 trials are currently recruiting.

204 US clinical trials · 56 currently recruiting

COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.

The research picture

COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.

56
recruiting participants now
27%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
15
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 118Phase 242Phase 321Phase 49

Active & Recent Trials

204 total, page 2 of 5

RECRUITING NA 48 participants

Evaluating the Impact of Social Music

Yale University

NCT06513910

RECRUITING Phase 2 40 participants

A Nasal Treatment for COVID-19

Indiana University

NCT05799521

RECRUITING NA 40 participants

A Study of Healthy Microbiome, Healthy Mind

Mayo Clinic

NCT06020703

RECRUITING Phase 2 24 participants

Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise

Ohio State University Comprehensive Cancer Center

NCT04427566

RECRUITING Phase 2 21 participants

Arginine Replacement Therapy in COVID-19

Emory University

NCT05855330

RECRUITING NA 20 participants

CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19

University of California, San Francisco

NCT05530317

ACTIVE NOT RECRUITING 10,000,000 participants

COVID-19 Symptom Tracker

King's College London

NCT04331509

ACTIVE NOT RECRUITING 100,000 participants

Duke COVID-19 Shared Data and Specimen Repository

Duke University

NCT04368234

ACTIVE NOT RECRUITING 99,000 participants

A Study to Learn How Paxlovid [Nirmatrelvir-ritonavir/PF-07321332] Works in COVID-19 Patients Who Are Elderly or Have Medical Conditions.

Pfizer

NCT07261085

ACTIVE NOT RECRUITING 65,000 participants

COVID-19 & Psychiatry: A Retrospective Chart Review

Northwestern University

NCT05244096

ACTIVE NOT RECRUITING NA 30,000 participants

A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning

AgileMD

NCT05893420

ACTIVE NOT RECRUITING 19,275 participants

COVID-19 and Cancer Consortium Registry

Vanderbilt-Ingram Cancer Center

NCT04354701

ACTIVE NOT RECRUITING Phase 2 10,400 participants

A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection

Vaxart

NCT06672055

ACTIVE NOT RECRUITING 4,000 participants

Project REMOTE (REimagining Measurements and Operations of Translational Endpoints)

Biomedical Advanced Research and Development Authority

NCT06776367

ACTIVE NOT RECRUITING Phase 2 3,600 participants

Study to Evaluate Safety and Immunogenicity of COVID-19 Vaccine in Children 6 Months to < 12 Years

Novavax

NCT05468736

ACTIVE NOT RECRUITING 2,660 participants

Retail COVID-19 Study

Biomedical Advanced Research and Development Authority

NCT06761612

ACTIVE NOT RECRUITING 2,600 participants

COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers

Villanova University

NCT04370821

ACTIVE NOT RECRUITING Phase 3 1,770 participants

Study of VYD2311 for the Prevention of COVID-19

Invivyd

NCT07298434

ACTIVE NOT RECRUITING Phase 2 1,500 participants

I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients

QuantumLeap Healthcare Collaborative

NCT04488081

ACTIVE NOT RECRUITING Phase 4 1,000 participants

COVID-19 Reactogenicity

Marcel Curlin

NCT07051031

ACTIVE NOT RECRUITING 1,000 participants

COVID-19 Quick Start - Test and Treat in Africa

Duke University

NCT06360783

ACTIVE NOT RECRUITING 999 participants

A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza

Pfizer

NCT05160636

ACTIVE NOT RECRUITING NA 988 participants

Engaging Staff to Improve COVID-19 Vaccination Response at Long-Term Care Facilities

Kaiser Permanente

NCT05449418

ACTIVE NOT RECRUITING Phase 3 760 participants

A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years

BioNTech SE

NCT07069309

ACTIVE NOT RECRUITING Phase 3 676 participants

Safety and Immunogenicity of NVX-CoV2705

Sanofi

NCT07079670

ACTIVE NOT RECRUITING Phase 4 660 participants

Impact of Reactogenicity of the 2024-2025 COVID-19 Vaccines on Health Care Workers and First Responders in the United States

Novavax

NCT06633835

ACTIVE NOT RECRUITING 583 participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04411147

ACTIVE NOT RECRUITING 500 participants

Long Term Outcomes of Patients With COVID-19

University of Chicago

NCT04360538

ACTIVE NOT RECRUITING Phase 2 432 participants

A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults

CyanVac

NCT06742281

ACTIVE NOT RECRUITING NA 398 participants

Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement

University of California, San Diego

NCT05841810

ACTIVE NOT RECRUITING 374 participants

ARMOR-Household: Characterizing Transmission of COVID-19 in Households of SARS-CoV-2 Index Cases

Columbia University

NCT05467917

ACTIVE NOT RECRUITING Phase 3 343 participants

A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That Are Considered at Higher Risk of Severe COVID-19

BioNTech SE

NCT07222384

ACTIVE NOT RECRUITING 300 participants

SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies

The Geneva Foundation

NCT05765396

ACTIVE NOT RECRUITING Phase 2 227 participants

A Phase 2 Trial of the Immunogenicity and Safety of CVXGA Intranasal COVID Vaccine in Healthy Adults

CyanVac

NCT05736835

ACTIVE NOT RECRUITING 201 participants

COVID-19 Biorepository

University of Kansas Medical Center

NCT04568148

ACTIVE NOT RECRUITING Phase 2 144 participants

A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia

The University of Texas Medical Branch, Galveston

NCT05815485

ACTIVE NOT RECRUITING Phase 4 95 participants

Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection

Medical University of South Carolina

NCT04482673

ACTIVE NOT RECRUITING 83 participants

Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans

National Institute on Aging (NIA)

NCT04565067

ACTIVE NOT RECRUITING NA 80 participants

Impact of Lp299v on Vascular Function in Patients With PASC

Medical College of Wisconsin

NCT05227170

ACTIVE NOT RECRUITING Phase 1 80 participants

Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET)

Ohio State University

NCT05881135

ACTIVE NOT RECRUITING 78 participants

A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans

National Institute on Aging (NIA)

NCT04852289

ACTIVE NOT RECRUITING Phase 1 60 participants

A First in Human Study to Evaluate the Safety and Immunogenicity of RBM-001 in Healthy Adult Volunteers

Rock BioMedical

NCT06878170

ACTIVE NOT RECRUITING NA 60 participants

Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases

Northwestern University

NCT05822219

ACTIVE NOT RECRUITING Phase 1 60 participants

Safety, Reactogenicity, and Immunogenicity Trial of STX-S SARS-CoV-2 Vaccine in Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT07095231

ACTIVE NOT RECRUITING Phase 2 56 participants

Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19

Northwell Health

NCT04724720

ACTIVE NOT RECRUITING Phase 1 48 participants

COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE)

National Institutes of Health Clinical Center (CC)

NCT04595773

ACTIVE NOT RECRUITING Phase 2 48 participants

A Study of N-acetylcysteine in Patients With COVID-19 Infection

Memorial Sloan Kettering Cancer Center

NCT04374461

ACTIVE NOT RECRUITING Phase 2 37 participants

Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia

Ohio State University Comprehensive Cancer Center

NCT04466683

ACTIVE NOT RECRUITING Phase 1 30 participants

Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT07183709

ACTIVE NOT RECRUITING 1 participants

A Study to Learn About How Well Yearly Updates to the COVID-19 Vaccine Work to Protect People From COVID-19 and How Much Money People Spend on Healthcare for COVID-19

Pfizer

NCT06923137

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 42
Phase 3 21
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COVID-19 Trial Landscape

204 indexed COVID-19 studies · 56 recruiting (27%).

Phase mix: 30 late (III/IV) vs 60 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COVID-19?

PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COVID-19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.