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Hypogonadism clinical trials
5 of 22 indexed Hypogonadism trials are currently recruiting.
22 US clinical trials · 5 currently recruiting
Hypogonadism is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Environmental Health Sciences (NIEHS), running 2 of these trials.
The research picture
Hypogonadism has 22 registered US clinical trials, 5 of them open to new participants right now, about 23% of the total.
- 5
- recruiting participants now
- 23%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 2
- top sponsor: National Institute of Environmental Health Sciences (NIEHS)
Active & Recent Trials
22 total, page 1 of 1
Inherited Reproductive Disorders
National Institute of Environmental Health Sciences (NIEHS)
NCT01500447
Observation of Environment and Reproductive-Endocrine Effects
National Institute of Environmental Health Sciences (NIEHS)
NCT06280807
Adaptions and Resiliency to Multi-Stressor OpeRations
Bradley Nindl
NCT06455969
The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population
Walter Reed National Military Medical Center
NCT06247267
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
North Florida Foundation for Research and Education
NCT04460872
A Phase 4 Study to Evaluate Adrenal Function in Hypogonadal Men Treated With JATENZO® for 12 Months
Tolmar
NCT06385509
Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism
VA Office of Research and Development
NCT03887936
Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone
Emory University
NCT04731376
Testosterone Replacement in Older Men and Atherosclerosis Progression
Brigham and Women's Hospital
NCT00287586
A Preliminary Clinical Study to Evaluate Fispemifene in the Treatment of Hypogonadism
QuatRx Pharmaceuticals Company
NCT00290134
The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel
Eli Lilly and Company
NCT01893281
Testopel ® vs. Generic Testosterone Pellets.
University of Miami
NCT04523480
Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement
National Institute of Mental Health (NIMH)
NCT00001412
28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men
GlaxoSmithKline
NCT00398580
Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems
Watson Pharmaceuticals
NCT01323140
Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00470990
Testosterone and Growth Hormone for Bone Loss in Men
University of Pennsylvania
NCT00080483
Transdermal Testosterone Gel/Effect on Erection Quality as Measured by DIR
Lamm, Steven, M.D.
NCT00425568
Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure
Solvay Pharmaceuticals
NCT00998933
Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement
The Miriam Hospital
NCT00752869
The Effect of Various Amounts of Fat on PK of Oral Testosterone Undecanoate
Clarus Therapeutics
NCT02921386
ORAL T-6: Oral Androgens in Man-6
University of Washington
NCT00663793
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 6 |
| Phase 3 | 1 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hypogonadism Trial Landscape
22 indexed Hypogonadism studies · 5 recruiting (23%).
Phase mix: 7 late (III/IV) vs 9 early (I/II).
Top sponsor: National Institute of Environmental Health Sciences (NIEHS) (2 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hypogonadism?
PlainTrial tracks 22 US clinical trials for Hypogonadism, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hypogonadism?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.