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2026 data Public-data reference. official source

Hypogonadism

Open-data reference.

22 US clinical trials · 5 currently recruiting

Active & Recent Trials

RECRUITING 850 participants

Inherited Reproductive Disorders

National Institute of Environmental Health Sciences (NIEHS)

NCT01500447

RECRUITING 300 participants

Observation of Environment and Reproductive-Endocrine Effects

National Institute of Environmental Health Sciences (NIEHS)

NCT06280807

RECRUITING Phase 4 120 participants

Adaptions and Resiliency to Multi-Stressor OpeRations

Bradley Nindl

NCT06455969

RECRUITING 75 participants

The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population

Walter Reed National Military Medical Center

NCT06247267

RECRUITING Phase 2 21 participants

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

North Florida Foundation for Research and Education

NCT04460872

ACTIVE NOT RECRUITING Phase 4 110 participants

A Phase 4 Study to Evaluate Adrenal Function in Hypogonadal Men Treated With JATENZO® for 12 Months

Tolmar

NCT06385509

ACTIVE NOT RECRUITING Phase 4 92 participants

Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism

VA Office of Research and Development

NCT03887936

ACTIVE NOT RECRUITING Phase 1 56 participants

Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone

Emory University

NCT04731376

COMPLETED Phase 4 308 participants

Testosterone Replacement in Older Men and Atherosclerosis Progression

Brigham and Women's Hospital

NCT00287586

COMPLETED Phase 2 100 participants

A Preliminary Clinical Study to Evaluate Fispemifene in the Treatment of Hypogonadism

QuatRx Pharmaceuticals Company

NCT00290134

COMPLETED Phase 4 78 participants

The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel

Eli Lilly and Company

NCT01893281

COMPLETED Phase 3 75 participants

Testopel ® vs. Generic Testosterone Pellets.

University of Miami

NCT04523480

COMPLETED 70 participants

Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement

National Institute of Mental Health (NIMH)

NCT00001412

COMPLETED Phase 2 43 participants

28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men

GlaxoSmithKline

NCT00398580

COMPLETED Phase 2 40 participants

Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems

Watson Pharmaceuticals

NCT01323140

COMPLETED NA 40 participants

Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00470990

COMPLETED Phase 2 35 participants

Testosterone and Growth Hormone for Bone Loss in Men

University of Pennsylvania

NCT00080483

COMPLETED 30 participants

Transdermal Testosterone Gel/Effect on Erection Quality as Measured by DIR

Lamm, Steven, M.D.

NCT00425568

COMPLETED Phase 1 24 participants

Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure

Solvay Pharmaceuticals

NCT00998933

COMPLETED Phase 4 24 participants

Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement

The Miriam Hospital

NCT00752869

COMPLETED Phase 2 18 participants

The Effect of Various Amounts of Fat on PK of Oral Testosterone Undecanoate

Clarus Therapeutics

NCT02921386

COMPLETED Phase 1 16 participants

ORAL T-6: Oral Androgens in Man-6

University of Washington

NCT00663793

Phase Distribution

PhaseTrial count
Early Phase 1 3
Phase 2 6
Phase 3 1
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypogonadism Trial Landscape

ClinicalTrials.gov lists 22 US studies indexed under Hypogonadism, and 5 of those are currently open to recruitment — roughly 23% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hypogonadism shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hypogonadism is led by National Institute of Environmental Health Sciences (NIEHS) with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypogonadism?

PlainTrial tracks 22 US clinical trials for Hypogonadism, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypogonadism?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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