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NCT04802408 · ClinicalTrials.gov registry record · Phase 2
SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
A Phase 2 study of COVID-19 and SARS-CoV Infection, sponsored by Milton S. Hershey Medical Center.
- Active
- Registry status
- Phase 2
- Development phase
- 171
- Enrollment target
- 2
- Study locations
NCT04802408: Active Phase 2 study of COVID-19 and SARS-CoV Infection, sponsored by Milton S. Hershey Medical Center.
NCT04802408 is a Phase 2 study of COVID-19 and SARS-CoV Infection that is active but no longer recruiting, run by Milton S. Hershey Medical Center. The registered enrollment target is 171 participants, below the 38,464-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04802408, a Phase 2 study of COVID-19 and SARS-CoV Infection, is active but no longer recruiting, sponsored by Milton S. Hershey Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 171 participants
- Enrollment target
- 2
- Study locations
Study Summary
Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.
Primary Outcome
Primary Study Endpoints The primary endpoint is the change from baseline in measured viral load in the nose and mouth of adults aged 18-65 years with SARS-CoV-2 infection after 4 days of washes (Day 5 vs Day 1). This will be measured using quantitative PCR (qPCR) analysis, with standard procedures to make cDNA copies of the viral genomic RNA and using CDC recommended primers qPCR to determine viral load. Four separate regimens will be evaluated: 1% dilute baby shampoo nasal wash and a saline ora
Conditions Studied
Interventions
- COMBINATION_PRODUCT Shampoo and saline
- COMBINATION_PRODUCT Saline and Listerine
- COMBINATION_PRODUCT Shampoo and Listerine
- COMBINATION_PRODUCT Saline and Saline
Study Locations (2)
Pennsylvania
- Penn State Health Milton S. Hershey Medical Center - Hershey
- Penn State - State College
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2021-10-01 |
| Est. Completion | 2026-05-30 |
| Phase | Phase 2 |
What the registry record for NCT04802408 still lists
NCT04802408 is an interventional study that assigns participants to a tested intervention. The registered 171 participants enrollment target is mid-sized for trials with a published cap, below the 38,464-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with COVID-19 appearing as the primary indexed condition, and to 4 interventions - of which Shampoo and saline is the first listed.
NCT04802408 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04802408 about?
NCT04802408 is a clinical study titled "SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial". Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal s...
What is the current status of trial NCT04802408?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 171 participants. The study started on 2021-10-01. Estimated completion is 2026-05-30.
What conditions does trial NCT04802408 study?
This clinical trial studies the following conditions: COVID-19, SARS-CoV Infection.
What interventions are being tested in trial NCT04802408?
The interventions under investigation include: Shampoo and saline (COMBINATION_PRODUCT), Saline and Listerine (COMBINATION_PRODUCT), Shampoo and Listerine (COMBINATION_PRODUCT), Saline and Saline (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT04802408?
This trial is sponsored by Milton S. Hershey Medical Center, which has 396 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04802408 being conducted?
This trial has 2 study locations across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04802408's enrollment target sits among peer trials
171 165th of 298 higher than 134 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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