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NCT04565067 · ClinicalTrials.gov registry record
Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans
A clinical trial of COVID-19, sponsored by National Institute on Aging (NIA).
- Active
- Registry status
- 83
- Enrollment target
- 1
- Study location
NCT04565067: Active study of COVID-19, sponsored by National Institute on Aging (NIA).
NCT04565067 is a study of COVID-19 that is active but no longer recruiting, run by National Institute on Aging (NIA). The registered enrollment target is 83 participants, below the 38,465-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04565067, a study of COVID-19, is active but no longer recruiting, sponsored by National Institute on Aging (NIA).
- ACTIVE NOT RECRUITING
- Registry status
- 83 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: The higher death rate from COVID-19 in the older population is associated with low CD8 T cell counts in the blood. Researchers want to learn the status of CD8 T cells specific to SARS-CoV-2 and their changes with aging and in COVID-19. This may help to identify why COVID-19 is particularly lethal in the elderly and help to create an effective vaccine against SARS-CoV-2 in the elderly. Objective: To identify SARS-CoV-2 specific CD8 T cells in humans, and to determine their quantity and quality in people who have recovered from COVID-19. Eligibility: Maryland residents age 18 and older who have tested positive for and recovered from COVID-19. Design: Participants will be screened by phone. They must be able to provide a copy of their positive COVID-19 test result. Participants will visit the NIA/Clinical Research Unit. The visit will take about 1 hour. Laboratory tests showing a positive COVID-19 result will be verified. Participants vital signs will be checked. This will include blood pressure, temperature, pulse, and respiration. Height and weight will be measured. Participants will have a medical history and medicine review. They will complete a COVID-19 questionnaire. Participants will have blood drawn. They will give a urine sample. Participants will give a saliva sample. They will rinse their mouth with water. After about 3 minutes, they will let saliva pool in the base of their mouth and then spit into a sterile container. Participants may be asked if they would be willing to return for optional visits at about 4 months and 1 year later. They will repeat the same laboratory sampling performed at the first visit. ...
Primary Outcome
We are investigating the presence or absence of various SARS-CoV-2 specific CD8 T cells in healthy adults and in COVID-19 recovered patients to understand the composition of CD8 T cell immunity in COVID-19 pathogenesis.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Aging, Clinical Research Unit - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 83 participants |
| Start Date | 2020-09-22 |
| Est. Completion | 2027-09-30 |
What the registry record for NCT04565067 still lists
NCT04565067 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 83 participants, a relatively small participant target, below the 38,465-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 0 interventions.
NCT04565067 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04565067 about?
NCT04565067 is a clinical study titled "Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans". Background: The higher death rate from COVID-19 in the older population is associated with low CD8 T cell counts in the blood. Researchers want to learn the status of CD8 T cells specific to SARS-CoV-2 and their changes with aging and in COVID-19. This may help to identify why COVID-19 is particula...
What is the current status of trial NCT04565067?
This trial is currently active not recruiting. The enrollment target is 83 participants. The study started on 2020-09-22. Estimated completion is 2027-09-30.
What conditions does trial NCT04565067 study?
This clinical trial studies the following conditions: COVID-19.
Who is sponsoring clinical trial NCT04565067?
This trial is sponsored by National Institute on Aging (NIA), which has 131 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04565067 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04565067's enrollment target sits among peer trials
83 214th of 298 higher than 85 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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