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NCT05227170 · ClinicalTrials.gov registry record · NA
Impact of Lp299v on Vascular Function in Patients With PASC
A NA study of COVID-19, sponsored by Medical College of Wisconsin.
- Active
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT05227170 is a NA study of COVID-19 that is active but no longer recruiting, run by Medical College of Wisconsin. The registered enrollment target is 80 participants, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05227170, a NA study of COVID-19, is active but no longer recruiting, sponsored by Medical College of Wisconsin.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
Emerging data show that SARS-CoV-2 infection causes gut microbiome changes strongly associated with Post-Acute Sequelae of SARS-CoV-2 (PASC). The investigators and others have established that an orally ingested probiotic (Lactobacillus plantarum 299v, Lp299v) reduces circulating levels of cell-free mitochondrial DNA (cf-mtDNA), decreases toll-like receptor 9 (TLR9) activation \[and downstream interleukin (IL-6)\], and improves micro- and macrovascular (brachial artery) endothelial dysfunction \[as measured by flow-mediated dilation (FMD%)\] in humans. Recently published data also report impaired brachial FMD% and increased vascular stiffness post-SARS-CoV-2 infection. Based on these data, the investigators hypothesize that supplementation with Lp299v will attenuate SARS-CoV-2 associated endothelial dysfunction by reducing cf-mtDNA, TLR9 activation, and inflammation.
Conditions Studied
Interventions
- OTHER Lactobacillus Plantarum 299v Freeze Dried Capsule
- OTHER Freeze Dried Potato Starch Capsule
Study Locations (1)
Wisconsin
- Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2022-04-29 |
| Est. Completion | 2026-03-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05227170
The ClinicalTrials.gov registry entry for NCT05227170 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 55,214-participant average among 203 other COVID-19 trials with a reported enrollment target (100% lower). The listed sponsor is Medical College of Wisconsin, which has 447 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 2 interventions - of which Lactobacillus Plantarum 299v Freeze Dried Capsule is the first listed.
NCT05227170 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05227170 about?
NCT05227170 is a clinical study titled "Impact of Lp299v on Vascular Function in Patients With PASC". Emerging data show that SARS-CoV-2 infection causes gut microbiome changes strongly associated with Post-Acute Sequelae of SARS-CoV-2 (PASC). The investigators and others have established that an orally ingested probiotic (Lactobacillus plantarum 299v, Lp299v) reduces circulating levels of cell-free...
What is the current status of trial NCT05227170?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2022-04-29. Estimated completion is 2026-03-31.
What conditions does trial NCT05227170 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT05227170?
The interventions under investigation include: Lactobacillus Plantarum 299v Freeze Dried Capsule (OTHER), Freeze Dried Potato Starch Capsule (OTHER).
Who is sponsoring clinical trial NCT05227170?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05227170 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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