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ClinicalTrials.gov 56 recruiting now official registry

COVID-19 clinical trials

56 of 204 indexed COVID-19 trials are currently recruiting.

204 US clinical trials · 56 currently recruiting

COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.

The research picture

COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.

56
recruiting participants now
27%
of trials open to enrollment
30
in Phase 3–4 (later-stage)
15
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 118Phase 242Phase 321Phase 49

Active & Recent Trials

204 total, page 4 of 5

COMPLETED NA 290 participants

Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning

Dascena

NCT04423991

COMPLETED Phase 2 282 participants

A Study of S-892216 in Participants With COVID-19

Shionogi

NCT06928051

COMPLETED NA 274 participants

COVID-19 Testing and Vaccination Among Spanish Speakers

Wake Forest University Health Sciences

NCT05302908

COMPLETED Early Phase 1 245 participants

SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding

University of Wisconsin, Madison

NCT04478019

COMPLETED 232 participants

Clinical Performance Evaluation of SARS-CoV-2 (COVID-19) Antigen Assay in Point of Care Settings

Freedom For All Diagnostics

NCT05213897

COMPLETED Phase 2 231 participants

A Study to Evaluate EDP-235 in Non-hospitalized Adults With COVID-19

Enanta Pharmaceuticals

NCT05616728

COMPLETED Phase 2 227 participants

A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)

Kinevant Sciences

NCT04351243

COMPLETED Phase 2 217 participants

The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2

Pulmotect

NCT04313023

COMPLETED Phase 2 201 participants

ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04988035

COMPLETED Phase 2 178 participants

A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection

NYU Langone Health

NCT04343989

COMPLETED 163 participants

COVID-19 Endoscopy Survey

Al-Azhar University

NCT04342637

COMPLETED Phase 2 159 participants

A Study of COVID 19 Convalescent Plasma in High Risk Patients With COVID 19 Infection

TriHealth

NCT04392232

COMPLETED 155 participants

Index Individuals in SARS-CoV-2 Prevention Research Studies (COVID-19 Index Individuals Companion Study)

University of Washington

NCT05074719

COMPLETED NA 152 participants

Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019

University of Pennsylvania

NCT04338009

COMPLETED 138 participants

PREP (Pre-Exposure Prophylaxis) of COVID-19

Ghady Haidar

NCT05461378

COMPLETED NA 129 participants

NOWDx Test for the Detection of Antibodies to COVID-19

NOWDiagnostics

NCT04690413

COMPLETED 129 participants

Assessment of Exam Findings in Coronavirus Disease 2019 (COVID-19) With Point-of-Care Ultrasonography (POCUS)

University of Minnesota

NCT04339998

COMPLETED Phase 2 124 participants

Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients

Golden Biotechnology Corporation

NCT04523181

COMPLETED Phase 1 114 participants

A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults

GlaxoSmithKline

NCT05972993

COMPLETED NA 112 participants

Coronavirus Disease of 2019 (COVID-19) Health Education Initiative for School Safety

University of Miami

NCT06938230

COMPLETED NA 112 participants

ReSET Aim 1b: Restarting Safe Education and Testing for Children With Medical Complexity - COVID-19 Testing in School With Children and Staff

University of Wisconsin, Madison

NCT04899245

COMPLETED Phase 2 109 participants

A Real World Study of Bamlanivimab in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)

Eli Lilly and Company

NCT04701658

COMPLETED Phase 1 106 participants

A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults

GlaxoSmithKline

NCT06680375

COMPLETED Phase 4 103 participants

Assessing Safety of Coronavirus Infection (COVID-19) Messenger RNA (mRNA) Vaccine Administration in the Setting of a Previous Adverse Reaction

University of Michigan

NCT05212610

COMPLETED Phase 2 103 participants

Evaluating the Efficacy of Convalescent Plasma in Symptomatic Outpatients Infected With COVID-19

Metro Infectious Disease Consultants

NCT04438057

COMPLETED NA 100 participants

Safe and Healthy Schools

University of Wisconsin, Madison

NCT05105789

COMPLETED Phase 1 99 participants

Safety, Reactogenicity, and Immunogenicity Trial of CV2CoV mRNA Vaccine Against SARS-CoV-2 in Seropositive Adult Participants

GlaxoSmithKline

NCT05260437

COMPLETED Phase 4 94 participants

Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19

Columbia University

NCT04367831

COMPLETED NA 93 participants

Rapid, Onsite COVID-19 Detection

University of Wisconsin, Madison

NCT04460690

COMPLETED NA 88 participants

Impact of Nasal Saline Irrigations on Viral Load in Patients With COVID-19

Vanderbilt University Medical Center

NCT04347538

COMPLETED Phase 2 85 participants

Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19

Intermountain Health Care

NCT04329832

COMPLETED Phase 2 81 participants

Cardiovascular Effects of COVID-19

NYU Langone Health

NCT04365699

COMPLETED 79 participants

WGS Analysis of COVID-19 Positive Patients

Vanda Pharmaceuticals

NCT04353401

COMPLETED Phase 2 77 participants

Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)

Washington University School of Medicine

NCT05947643

COMPLETED Phase 3 72 participants

Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy

The University of Texas Medical Branch, Galveston

NCT03554265

COMPLETED Phase 1 72 participants

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Apellis Pharmaceuticals

NCT04402060

COMPLETED Phase 2 70 participants

Camostat Mesylate in COVID-19 Outpatients

Yale University

NCT04353284

COMPLETED 66 participants

Hyperspectral Analysis of Sweat Metabolite Biometrics for Real-Time Detection of COVID-19

National Cancer Institute (NCI)

NCT05044780

COMPLETED Phase 2 63 participants

Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants

BeiGene

NCT04382586

COMPLETED 55 participants

Do EEG and Neurocognitive Assessments Correlate With COVID Brainfog Symptoms?

Texas Tech University Health Sciences Center, El Paso

NCT05303116

COMPLETED Phase 1 54 participants

RCT of Fomitopsis Officinalis and Trametes Versicolor to Treat COVID-19

Gordon Saxe

NCT04667247

COMPLETED NA 32 participants

Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19

University of Kentucky

NCT04412330

COMPLETED 30 participants

Home Usability Study of the SARS-CoV-2 (COVID-19) Test

Exact Sciences Corporation

NCT04395391

COMPLETED Phase 2 30 participants

Sodium Pyruvate Nasal Spray Treatment of COVID-19 Infection

Cellular Sciences

NCT04824365

COMPLETED Phase 3 30 participants

Frontline Clinician Psilocybin Study

University of Washington

NCT05163496

COMPLETED 28 participants

Cognitive Assessment in COVID-19 Positive Patients Using the DANA App

Johns Hopkins University

NCT05143333

COMPLETED NA 27 participants

Compass Course: COVID-19

Allina Health System

NCT05295238

COMPLETED Phase 1 26 participants

A Study of LY3819253 (LY-CoV555) in Participants Hospitalized for COVID-19

Eli Lilly and Company

NCT04411628

COMPLETED 22 participants

CPAP Efficacy in Post-COVID-19 Patients With Sleep Apnea

Venkatesh Krishnamurthy

NCT06052514

COMPLETED Phase 3 20 participants

Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease

Novartis Pharmaceuticals

NCT04358081

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 42
Phase 3 21
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the COVID-19 Trial Landscape

204 indexed COVID-19 studies · 56 recruiting (27%).

Phase mix: 30 late (III/IV) vs 60 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for COVID-19?

PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for COVID-19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.