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COVID-19 clinical trials
56 of 204 indexed COVID-19 trials are currently recruiting.
204 US clinical trials · 56 currently recruiting
COVID-19 is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 56 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 60 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 15 of these trials.
The research picture
COVID-19 has 204 registered US clinical trials, 56 of them open to new participants right now, about 27% of the total.
- 56
- recruiting participants now
- 27%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 15
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
204 total, page 4 of 5
Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning
Dascena
NCT04423991
A Study of S-892216 in Participants With COVID-19
Shionogi
NCT06928051
COVID-19 Testing and Vaccination Among Spanish Speakers
Wake Forest University Health Sciences
NCT05302908
SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding
University of Wisconsin, Madison
NCT04478019
Clinical Performance Evaluation of SARS-CoV-2 (COVID-19) Antigen Assay in Point of Care Settings
Freedom For All Diagnostics
NCT05213897
A Study to Evaluate EDP-235 in Non-hospitalized Adults With COVID-19
Enanta Pharmaceuticals
NCT05616728
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
Kinevant Sciences
NCT04351243
The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2
Pulmotect
NCT04313023
ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04988035
A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection
NYU Langone Health
NCT04343989
COVID-19 Endoscopy Survey
Al-Azhar University
NCT04342637
A Study of COVID 19 Convalescent Plasma in High Risk Patients With COVID 19 Infection
TriHealth
NCT04392232
Index Individuals in SARS-CoV-2 Prevention Research Studies (COVID-19 Index Individuals Companion Study)
University of Washington
NCT05074719
Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019
University of Pennsylvania
NCT04338009
PREP (Pre-Exposure Prophylaxis) of COVID-19
Ghady Haidar
NCT05461378
NOWDx Test for the Detection of Antibodies to COVID-19
NOWDiagnostics
NCT04690413
Assessment of Exam Findings in Coronavirus Disease 2019 (COVID-19) With Point-of-Care Ultrasonography (POCUS)
University of Minnesota
NCT04339998
Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients
Golden Biotechnology Corporation
NCT04523181
A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults
GlaxoSmithKline
NCT05972993
Coronavirus Disease of 2019 (COVID-19) Health Education Initiative for School Safety
University of Miami
NCT06938230
ReSET Aim 1b: Restarting Safe Education and Testing for Children With Medical Complexity - COVID-19 Testing in School With Children and Staff
University of Wisconsin, Madison
NCT04899245
A Real World Study of Bamlanivimab in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)
Eli Lilly and Company
NCT04701658
A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults
GlaxoSmithKline
NCT06680375
Assessing Safety of Coronavirus Infection (COVID-19) Messenger RNA (mRNA) Vaccine Administration in the Setting of a Previous Adverse Reaction
University of Michigan
NCT05212610
Evaluating the Efficacy of Convalescent Plasma in Symptomatic Outpatients Infected With COVID-19
Metro Infectious Disease Consultants
NCT04438057
Safe and Healthy Schools
University of Wisconsin, Madison
NCT05105789
Safety, Reactogenicity, and Immunogenicity Trial of CV2CoV mRNA Vaccine Against SARS-CoV-2 in Seropositive Adult Participants
GlaxoSmithKline
NCT05260437
Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19
Columbia University
NCT04367831
Rapid, Onsite COVID-19 Detection
University of Wisconsin, Madison
NCT04460690
Impact of Nasal Saline Irrigations on Viral Load in Patients With COVID-19
Vanderbilt University Medical Center
NCT04347538
Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19
Intermountain Health Care
NCT04329832
Cardiovascular Effects of COVID-19
NYU Langone Health
NCT04365699
WGS Analysis of COVID-19 Positive Patients
Vanda Pharmaceuticals
NCT04353401
Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)
Washington University School of Medicine
NCT05947643
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19
Apellis Pharmaceuticals
NCT04402060
Camostat Mesylate in COVID-19 Outpatients
Yale University
NCT04353284
Hyperspectral Analysis of Sweat Metabolite Biometrics for Real-Time Detection of COVID-19
National Cancer Institute (NCI)
NCT05044780
Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants
BeiGene
NCT04382586
Do EEG and Neurocognitive Assessments Correlate With COVID Brainfog Symptoms?
Texas Tech University Health Sciences Center, El Paso
NCT05303116
RCT of Fomitopsis Officinalis and Trametes Versicolor to Treat COVID-19
Gordon Saxe
NCT04667247
Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19
University of Kentucky
NCT04412330
Home Usability Study of the SARS-CoV-2 (COVID-19) Test
Exact Sciences Corporation
NCT04395391
Sodium Pyruvate Nasal Spray Treatment of COVID-19 Infection
Cellular Sciences
NCT04824365
Frontline Clinician Psilocybin Study
University of Washington
NCT05163496
Cognitive Assessment in COVID-19 Positive Patients Using the DANA App
Johns Hopkins University
NCT05143333
Compass Course: COVID-19
Allina Health System
NCT05295238
A Study of LY3819253 (LY-CoV555) in Participants Hospitalized for COVID-19
Eli Lilly and Company
NCT04411628
CPAP Efficacy in Post-COVID-19 Patients With Sleep Apnea
Venkatesh Krishnamurthy
NCT06052514
Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease
Novartis Pharmaceuticals
NCT04358081
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 42 |
| Phase 3 | 21 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the COVID-19 Trial Landscape
204 indexed COVID-19 studies · 56 recruiting (27%).
Phase mix: 30 late (III/IV) vs 60 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (15 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for COVID-19?
PlainTrial tracks 204 US clinical trials for COVID-19, of which 56 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for COVID-19?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.