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NCT04374461 · ClinicalTrials.gov registry record · Phase 2
A Study of N-acetylcysteine in Patients With COVID-19 Infection
A Phase 2 study of COVID-19, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 2
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT04374461: Active Phase 2 study of COVID-19, sponsored by Memorial Sloan Kettering Cancer Center.
NCT04374461 is a Phase 2 study of COVID-19 that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 48 participants, below the 38,465-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04374461, a Phase 2 study of COVID-19, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
The study researchers think that a medication called N-acetylcysteine can help fight the COVID-19 virus by boosting a type of cell in your immune system that attacks infections. By helping your immune system fight the virus, the researchers think that the infection will get better, which could allow the patient to be moved out of the critical care unit or go off a ventilator, or prevent them from moving into a critical care unit or going on a ventilator. The US Food and Drug Administration (FDA) has approved N-acetylcysteine to treat the liver side effects resulting from an overdose of the anti-inflammatory medication Tylenol® (acetaminophen). N-acetylcysteine is also used to loosen the thick mucus in the lungs of people with cystic fibrosis or chronic obstructive pulmonary disease (COPD). This study is the first to test N-acetylcysteine in people with severe COVID-19 infections.
Conditions Studied
Interventions
- DRUG N-acetylcysteine
- OTHER Peripheral Blood
Study Locations (1)
New York
- Memorial Sloan Kettering Cancer Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2020-05-01 |
| Est. Completion | 2026-05 |
| Phase | Phase 2 |
What the registry record for NCT04374461 still lists
NCT04374461 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 38,465-participant average among 298 other COVID-19 trials with a reported enrollment target (100% lower).
The record links to 1 condition, with COVID-19 appearing as the primary indexed condition, and to 2 interventions - of which N-acetylcysteine is the first listed.
NCT04374461 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT04374461 about?
NCT04374461 is a clinical study titled "A Study of N-acetylcysteine in Patients With COVID-19 Infection". The study researchers think that a medication called N-acetylcysteine can help fight the COVID-19 virus by boosting a type of cell in your immune system that attacks infections. By helping your immune system fight the virus, the researchers think that the infection will get better, which could allow...
What is the current status of trial NCT04374461?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 48 participants. The study started on 2020-05-01. Estimated completion is 2026-05.
What conditions does trial NCT04374461 study?
This clinical trial studies the following conditions: COVID-19.
What interventions are being tested in trial NCT04374461?
The interventions under investigation include: N-acetylcysteine (DRUG), Peripheral Blood (OTHER).
Who is sponsoring clinical trial NCT04374461?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04374461 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for COVID-19
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04374461's enrollment target sits among peer trials
48 250th of 298 higher than 47 of 298 other COVID-19 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other COVID-19 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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