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Cognitive Impairment: early-phase trial registry
46 of 106 indexed Cognitive Impairment trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #122 of 28,707 conditions by registered trial count.
106 US clinical trials · 46 currently recruiting · #122 of 28,707 conditions by registered trial count
Cognitive Impairment: 106 US clinical trials tracked, 46 recruiting.
Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.
Enrollment posture brief
Registry condition cognitive-impairment
OPEN 46 | RECR 43% | LATE 6 | EARLY 12 | RANK #122 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Healthy Volunteer (43% recruiting · 113 trials)
Cognitive Impairment lists 46 open slots (43% of 106 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cognitive Impairment on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Cognitive Impairment is recruiting above its size-band peers.
46 of 106 indexed trials (43.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Cognitive Impairment trials is spread across many organizations.
University of Alabama at Birmingham accounts for 7 of 106 trials (6.6%). 63 distinct sponsors appear on at least one study for this condition label.
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Typical Cognitive Impairment enrolment sits around 83 participants.
Median target enrolment is 83 among the 106 trials that report a genuine target (sentinel values excluded). 62 of those (58.5%) plan for fewer than 100 participants.
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Cognitive Impairment research is mostly interventional.
84 interventional and 22 observational studies make up this index (79.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
106 total, page 2 of 3
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)
Columbia University
NCT03121209
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
PennPET Explorer Scanner Evaluation
University of Pennsylvania
NCT04617912
Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
University of California, Davis
NCT05027789
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study
Vanderbilt University Medical Center
NCT04889417
Music Improvisation Training on Cognitive Function in Older Adults
University of California, San Francisco
NCT06721390
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
University of California, Los Angeles
NCT05235113
Community Recreation to Enhance Function in Aging
State University of New York at Buffalo
NCT07104435
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
University of Illinois at Chicago
NCT05930821
Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness
Vanderbilt University
NCT00937001
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
University of Washington
NCT05467410
Optimizing Function and Independence Through iHI-FIVES
VA Office of Research and Development
NCT03474380
Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)
University of Washington
NCT01708304
e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems
Indiana University
NCT00182832
LifeBio Memory Digital Reminiscence Platform
Benjamin Rose Institute on Aging
NCT04769466
DETECT and Retinal Outcomes in Hypertension
Emory University
NCT01815567
Preoperative Cognitive Screening in Older Spinal Surgical Patients
Brigham and Women's Hospital
NCT02922634
Assessment of Cognitive and Functional Impairment in Older Patients After ERCP
Vanderbilt University Medical Center
NCT03762954
COPD-Related Physiology and the Brain
Karin Hoth
NCT03269721
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Indiana University
NCT02213900
Anticipating Decline and Providing Therapy
Wake Forest University Health Sciences
NCT06182995
A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
Eli Lilly and Company
NCT04640077
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
VA Office of Research and Development
NCT01670526
Involving Family to Improve Communication in Primary Care
Johns Hopkins Bloomberg School of Public Health
NCT02986958
Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer
University of Rochester NCORP Research Base
NCT03186638
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
University of Rochester
NCT04669301
Nutrition, Physical Activity, and Cognition in Breast Cancer Survivors
Texas State University, San Marcos
NCT02591316
Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults
George Mason University
NCT04281654
11C-PIB PET Study in MESA at Columbia University
José A. Luchsinger
NCT03981380
The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial
University of Southern California
NCT00605072
SNIFF - Combo INI+EMPA Trial
Wake Forest University Health Sciences
NCT05081219
Computerized Cognitive Training in Breast Cancer Survivors
Ohio State University
NCT05570604
Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT
Kessler Foundation
NCT03677440
The Effects of Cannabidiol on the Driving Ability of Healthy Adults
West Virginia University
NCT04590495
The Role Of Cognitive Impairment In The Use Of The Diskus Inhaler
Synergy Health Solutions
NCT00891059
rTMS for Cognitive Rehabilitation After TBI
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03642158
Gene Expression, Meditative Movement, and Emotional Distress (GME)
Arizona State University
NCT04213872
Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)
University of Pennsylvania
NCT03291340
SimpleC Wellness Platform With Social Robot Interaction
SimpleC
NCT05296239
Movement Intervention for Memory Enhancement
Albert Einstein College of Medicine
NCT03475316
Mental Ability Challenge Study in Adults With and Without HIV
Vanderbilt University Medical Center
NCT03244488
Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
Johns Hopkins University
NCT00294554
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
University of Colorado, Denver
NCT03112226
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
University of North Carolina, Greensboro
NCT05462977
Cognitive Rehabilitation in Sickle Cell Disease
Duke University
NCT01793740
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 10 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Cognitive Impairment records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cognitive Impairment trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cognitive Impairment page
106 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Cognitive Impairment trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Alabama at Birmingham sponsors the most Cognitive Impairment trials on record, review their full trial history before evaluating a specific study. See University of Alabama at Birmingham's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cognitive Impairment condition card totals 106 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.