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ClinicalTrials.gov 46 recruiting now official registry

Cognitive Impairment clinical trials

46 of 106 indexed Cognitive Impairment trials are currently recruiting.

106 US clinical trials · 46 currently recruiting

Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.

The research picture

Cognitive Impairment has 106 registered US clinical trials, 46 of them open to new participants right now, about 43% of the total.

46
recruiting participants now
43%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
7
top sponsor: University of Alabama at Birmingham
Phase 12Phase 210Phase 34Phase 42

Active & Recent Trials

106 total, page 2 of 3

ACTIVE NOT RECRUITING 432 participants

Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study

Vanderbilt University Medical Center

NCT03098459

ACTIVE NOT RECRUITING 400 participants

Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey

C2N Diagnostics

NCT06025877

ACTIVE NOT RECRUITING Phase 3 385 participants

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)

Columbia University

NCT03121209

ACTIVE NOT RECRUITING 312 participants

Measuring Outcomes of Activity in Intensive Care

Vanderbilt University Medical Center

NCT03115840

ACTIVE NOT RECRUITING NA 268 participants

PennPET Explorer Scanner Evaluation

University of Pennsylvania

NCT04617912

ACTIVE NOT RECRUITING NA 263 participants

Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention

University of California, Davis

NCT05027789

ACTIVE NOT RECRUITING NA 250 participants

COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study

Vanderbilt University Medical Center

NCT04889417

ACTIVE NOT RECRUITING NA 238 participants

Music Improvisation Training on Cognitive Function in Older Adults

University of California, San Francisco

NCT06721390

ACTIVE NOT RECRUITING NA 84 participants

Remote Game-based Exercise Program for Cognitive and Motor Function Improvement

University of California, Los Angeles

NCT05235113

ACTIVE NOT RECRUITING NA 80 participants

Community Recreation to Enhance Function in Aging

State University of New York at Buffalo

NCT07104435

ACTIVE NOT RECRUITING NA 60 participants

Multi-Center Study of Sensory Stimulation to Improve Brain Function

Cognito Therapeutics

NCT03556280

ACTIVE NOT RECRUITING NA 51 participants

Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis

University of Illinois at Chicago

NCT05930821

ACTIVE NOT RECRUITING NA 50 participants

Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness

Vanderbilt University

NCT00937001

ACTIVE NOT RECRUITING NA 40 participants

Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors

University of Washington

NCT05467410

COMPLETED NA 1,406 participants

Optimizing Function and Independence Through iHI-FIVES

VA Office of Research and Development

NCT03474380

COMPLETED NA 510 participants

Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)

University of Washington

NCT01708304

COMPLETED NA 424 participants

e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems

Indiana University

NCT00182832

COMPLETED NA 234 participants

LifeBio Memory Digital Reminiscence Platform

Benjamin Rose Institute on Aging

NCT04769466

COMPLETED 234 participants

DETECT and Retinal Outcomes in Hypertension

Emory University

NCT01815567

COMPLETED 229 participants

Preoperative Cognitive Screening in Older Spinal Surgical Patients

Brigham and Women's Hospital

NCT02922634

COMPLETED 215 participants

Assessment of Cognitive and Functional Impairment in Older Patients After ERCP

Vanderbilt University Medical Center

NCT03762954

COMPLETED 170 participants

COPD-Related Physiology and the Brain

Karin Hoth

NCT03269721

COMPLETED Phase 4 135 participants

Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy

Indiana University

NCT02213900

COMPLETED NA 109 participants

Anticipating Decline and Providing Therapy

Wake Forest University Health Sciences

NCT06182995

COMPLETED Phase 2 95 participants

A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)

Eli Lilly and Company

NCT04640077

COMPLETED Phase 3 94 participants

Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI

VA Office of Research and Development

NCT01670526

COMPLETED NA 93 participants

Involving Family to Improve Communication in Primary Care

Johns Hopkins Bloomberg School of Public Health

NCT02986958

COMPLETED Phase 2 87 participants

Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

University of Rochester NCORP Research Base

NCT03186638

COMPLETED Phase 2 83 participants

Gulf War Illness Inflammation Reduction Trial

Minneapolis Veterans Affairs Medical Center

NCT02506192

COMPLETED Phase 3 72 participants

Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy

The University of Texas Medical Branch, Galveston

NCT03554265

COMPLETED NA 72 participants

Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II

University of Rochester

NCT04669301

COMPLETED 68 participants

Nutrition, Physical Activity, and Cognition in Breast Cancer Survivors

Texas State University, San Marcos

NCT02591316

COMPLETED NA 64 participants

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

George Mason University

NCT04281654

COMPLETED 59 participants

11C-PIB PET Study in MESA at Columbia University

José A. Luchsinger

NCT03981380

COMPLETED Phase 2 53 participants

The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial

University of Southern California

NCT00605072

COMPLETED Phase 2 47 participants

SNIFF - Combo INI+EMPA Trial

Wake Forest University Health Sciences

NCT05081219

COMPLETED NA 46 participants

Computerized Cognitive Training in Breast Cancer Survivors

Ohio State University

NCT05570604

COMPLETED NA 43 participants

Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT

Kessler Foundation

NCT03677440

COMPLETED Phase 2 40 participants

The Effects of Cannabidiol on the Driving Ability of Healthy Adults

West Virginia University

NCT04590495

COMPLETED 40 participants

The Role Of Cognitive Impairment In The Use Of The Diskus Inhaler

Synergy Health Solutions

NCT00891059

COMPLETED NA 34 participants

rTMS for Cognitive Rehabilitation After TBI

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT03642158

COMPLETED NA 27 participants

Gene Expression, Meditative Movement, and Emotional Distress (GME)

Arizona State University

NCT04213872

COMPLETED 27 participants

Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)

University of Pennsylvania

NCT03291340

COMPLETED NA 26 participants

SimpleC Wellness Platform With Social Robot Interaction

SimpleC

NCT05296239

COMPLETED NA 25 participants

Movement Intervention for Memory Enhancement

Albert Einstein College of Medicine

NCT03475316

COMPLETED 22 participants

Mental Ability Challenge Study in Adults With and Without HIV

Vanderbilt University Medical Center

NCT03244488

COMPLETED NA 20 participants

Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia

Johns Hopkins University

NCT00294554

COMPLETED NA 19 participants

Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function

University of Colorado, Denver

NCT03112226

COMPLETED NA 18 participants

Rhythmically Entrained Exercise in Community-Dwelling Older Adults

University of North Carolina, Greensboro

NCT05462977

COMPLETED NA 18 participants

Cognitive Rehabilitation in Sickle Cell Disease

Duke University

NCT01793740

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Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 10
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cognitive Impairment Trial Landscape

106 indexed Cognitive Impairment studies · 46 recruiting (43%).

Phase mix: 6 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Alabama at Birmingham (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cognitive Impairment?

PlainTrial tracks 106 US clinical trials for Cognitive Impairment, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cognitive Impairment?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.