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Cognitive Impairment clinical trials
46 of 106 indexed Cognitive Impairment trials are currently recruiting.
106 US clinical trials · 46 currently recruiting
Cognitive Impairment is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Alabama at Birmingham, running 7 of these trials.
The research picture
Cognitive Impairment has 106 registered US clinical trials, 46 of them open to new participants right now, about 43% of the total.
- 46
- recruiting participants now
- 43%
- of trials open to enrollment
- 6
- in Phase 3–4 (later-stage)
- 7
- top sponsor: University of Alabama at Birmingham
Active & Recent Trials
106 total, page 2 of 3
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)
Columbia University
NCT03121209
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
PennPET Explorer Scanner Evaluation
University of Pennsylvania
NCT04617912
Brain Boosters 2 in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention
University of California, Davis
NCT05027789
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study
Vanderbilt University Medical Center
NCT04889417
Music Improvisation Training on Cognitive Function in Older Adults
University of California, San Francisco
NCT06721390
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
University of California, Los Angeles
NCT05235113
Community Recreation to Enhance Function in Aging
State University of New York at Buffalo
NCT07104435
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
University of Illinois at Chicago
NCT05930821
Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness
Vanderbilt University
NCT00937001
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
University of Washington
NCT05467410
Optimizing Function and Independence Through iHI-FIVES
VA Office of Research and Development
NCT03474380
Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)
University of Washington
NCT01708304
e-CHAMP: Enhancing Care for Hospitalized Older Adults With Memory Problems
Indiana University
NCT00182832
LifeBio Memory Digital Reminiscence Platform
Benjamin Rose Institute on Aging
NCT04769466
DETECT and Retinal Outcomes in Hypertension
Emory University
NCT01815567
Preoperative Cognitive Screening in Older Spinal Surgical Patients
Brigham and Women's Hospital
NCT02922634
Assessment of Cognitive and Functional Impairment in Older Patients After ERCP
Vanderbilt University Medical Center
NCT03762954
COPD-Related Physiology and the Brain
Karin Hoth
NCT03269721
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Indiana University
NCT02213900
Anticipating Decline and Providing Therapy
Wake Forest University Health Sciences
NCT06182995
A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
Eli Lilly and Company
NCT04640077
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
VA Office of Research and Development
NCT01670526
Involving Family to Improve Communication in Primary Care
Johns Hopkins Bloomberg School of Public Health
NCT02986958
Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer
University of Rochester NCORP Research Base
NCT03186638
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
University of Rochester
NCT04669301
Nutrition, Physical Activity, and Cognition in Breast Cancer Survivors
Texas State University, San Marcos
NCT02591316
Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults
George Mason University
NCT04281654
11C-PIB PET Study in MESA at Columbia University
José A. Luchsinger
NCT03981380
The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial
University of Southern California
NCT00605072
SNIFF - Combo INI+EMPA Trial
Wake Forest University Health Sciences
NCT05081219
Computerized Cognitive Training in Breast Cancer Survivors
Ohio State University
NCT05570604
Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT
Kessler Foundation
NCT03677440
The Effects of Cannabidiol on the Driving Ability of Healthy Adults
West Virginia University
NCT04590495
The Role Of Cognitive Impairment In The Use Of The Diskus Inhaler
Synergy Health Solutions
NCT00891059
rTMS for Cognitive Rehabilitation After TBI
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT03642158
Gene Expression, Meditative Movement, and Emotional Distress (GME)
Arizona State University
NCT04213872
Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)
University of Pennsylvania
NCT03291340
SimpleC Wellness Platform With Social Robot Interaction
SimpleC
NCT05296239
Movement Intervention for Memory Enhancement
Albert Einstein College of Medicine
NCT03475316
Mental Ability Challenge Study in Adults With and Without HIV
Vanderbilt University Medical Center
NCT03244488
Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
Johns Hopkins University
NCT00294554
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
University of Colorado, Denver
NCT03112226
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
University of North Carolina, Greensboro
NCT05462977
Cognitive Rehabilitation in Sickle Cell Disease
Duke University
NCT01793740
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 10 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cognitive Impairment Trial Landscape
106 indexed Cognitive Impairment studies · 46 recruiting (43%).
Phase mix: 6 late (III/IV) vs 12 early (I/II).
Top sponsor: University of Alabama at Birmingham (7 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cognitive Impairment?
PlainTrial tracks 106 US clinical trials for Cognitive Impairment, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cognitive Impairment?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.