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NCT03677440 · ClinicalTrials.gov registry record · NA
Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT
A NA study of Multiple Sclerosis and Cognitive Impairment, sponsored by Kessler Foundation.
- Completed
- Registry status
- NA
- Development phase
- 43
- Enrollment target
- 1
- Study location
NCT03677440: Completed NA study of Multiple Sclerosis and Cognitive Impairment, sponsored by Kessler Foundation.
NCT03677440 is a NA study of Multiple Sclerosis and Cognitive Impairment that has completed, run by Kessler Foundation. The registered enrollment target is 43 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03677440, a NA study of Multiple Sclerosis and Cognitive Impairment, has completed, sponsored by Kessler Foundation.
- COMPLETED
- Registry status
- NA
- Development phase
- 43 participants
- Enrollment target
- 1
- Study location
Study Summary
Cognitive impairment is highly prevalent, poorly-managed, and disabling in persons with MS and exercise training might represent a promising approach to manage this symptom of the disease. The proposed study aims to examine the effects of 3-months of supervised, progressive (both intensity and duration) treadmill walking exercise training (designed based on pilot work and American College of Sports Medicine guidelines) compared with an active control condition (i.e., stretching-and-toning activities) on cognitive processing speed and functional MRI outcomes in 88 cognitively-impaired persons with MS. This study is critical for providing evidence supporting treadmill walking exercise training as a behavioral approach for managing slowed cognitive processing speed (i.e., the most common MS-related cognitive impairment) and improving brain health in persons with MS.
Primary Outcome
Raw (Total) Score from the Symbol Digit Modalities Test (0-110; higher scores indicate faster cognitive processing speed)
Conditions Studied
Interventions
- BEHAVIORAL Treadmill Walking Exercise Training
- BEHAVIORAL Stretching-and-Toning Exercise Training
Study Locations (1)
New Jersey
- Kessler Foundation - West Orange
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 43 participants |
| Start Date | 2019-02-05 |
| Est. Completion | 2024-12-31 |
| Phase | NA |
What the finished NCT03677440 record still lists
NCT03677440 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 43 participants, a relatively small participant target, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Treadmill Walking Exercise Training is the first listed.
NCT03677440 reports a single indexed study location in New Jersey.
Frequently Asked Questions
What is clinical trial NCT03677440 about?
NCT03677440 is a clinical study titled "Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT". Cognitive impairment is highly prevalent, poorly-managed, and disabling in persons with MS and exercise training might represent a promising approach to manage this symptom of the disease. The proposed study aims to examine the effects of 3-months of supervised, progressive (both intensity and durat...
What is the current status of trial NCT03677440?
This trial is currently completed. It is a NA study. The enrollment target is 43 participants. The study started on 2019-02-05. Estimated completion is 2024-12-31.
What conditions does trial NCT03677440 study?
This clinical trial studies the following conditions: Multiple Sclerosis, Cognitive Impairment.
What interventions are being tested in trial NCT03677440?
The interventions under investigation include: Treadmill Walking Exercise Training (BEHAVIORAL), Stretching-and-Toning Exercise Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT03677440?
This trial is sponsored by Kessler Foundation, which has 104 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03677440 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03677440's enrollment target sits among peer trials
43 194th of 315 higher than 122 of 315 other Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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