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NCT03750825 · ClinicalTrials.gov registry record · NA
Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)
A NA study of Cigarette Smoking, sponsored by University of Southern California.
- Active
- Registry status
- NA
- Development phase
- 150
- Enrollment target
- 1
- Study location
NCT03750825: Active NA study of Cigarette Smoking, sponsored by University of Southern California.
NCT03750825 is a NA study of Cigarette Smoking that is active but no longer recruiting, run by University of Southern California. The registered enrollment target is 150 participants, below the 173-participant average among 45 other Cigarette Smoking trials with a reported enrollment target (13% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03750825, a NA study of Cigarette Smoking, is active but no longer recruiting, sponsored by University of Southern California.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will address a growing public health concern, namely, the health risks or benefits of e-cig use relative to cigarette smoking. The investigators will use biomarkers of early effects of relevance to cancer to determine the carcinogenic potential of e-cig use relative to cigarette smoking in oral epithelium, which is a target tissue for smoking-associated cancer. The study population will consist of one group of smokers who are interested in switching to e-cig use (Grp 1), one group of smokers who do not intend to change their smoking habits (Grp 2), and one group of non-users who would like to maintain their nonsmoking non-vaping status (Grp 3); The total number of participants in this project is 150 (n = 50, each group). The investigators will use an integrative 'multi-omics' approach complemented with single-locus/gene validation analyses to detect temporal changes in the genome, epigenome, and transcriptome relevant to cancer in the oral cells of the participants as the intervention progresses.
Primary Outcome
Number and location of DNA damage
Conditions Studied
Interventions
- DEVICE NIDA Standard Research E-cigarette (SREC)
Study Locations (1)
California
- University of Southern California, Health Sciences Campus - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2021-12-01 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
What the registry record for NCT03750825 still lists
NCT03750825 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 173-participant average among 45 other Cigarette Smoking trials with a reported enrollment target (13% lower).
The record links to 1 condition, with Cigarette Smoking appearing as the primary indexed condition, and to 1 intervention - of which NIDA Standard Research E-cigarette (SREC) is the first listed.
NCT03750825 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03750825 about?
NCT03750825 is a clinical study titled "Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)". This project will address a growing public health concern, namely, the health risks or benefits of e-cig use relative to cigarette smoking. The investigators will use biomarkers of early effects of relevance to cancer to determine the carcinogenic potential of e-cig use relative to cigarette smoking...
What is the current status of trial NCT03750825?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 150 participants. The study started on 2021-12-01. Estimated completion is 2028-07-31.
What conditions does trial NCT03750825 study?
This clinical trial studies the following conditions: Cigarette Smoking.
What interventions are being tested in trial NCT03750825?
The interventions under investigation include: NIDA Standard Research E-cigarette (SREC) (DEVICE).
Who is sponsoring clinical trial NCT03750825?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03750825 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cigarette Smoking
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03750825's enrollment target sits among peer trials
150 19th of 45 higher than 26 of 45 other Cigarette Smoking trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cigarette Smoking trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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