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ClinicalTrials.gov 134 recruiting now official registry

Cardiovascular Diseases clinical trials

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

304 US clinical trials · 134 currently recruiting

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

The research picture

Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.

134
recruiting participants now
44%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
10
top sponsor: Duke University
Phase 110Phase 218Phase 313Phase 413

Active & Recent Trials

304 total, page 5 of 7

COMPLETED Phase 3 911 participants

IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

Tufts Medical Center

NCT00091507

COMPLETED Phase 2 905 participants

A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)

Eli Lilly and Company

NCT00059215

COMPLETED 896 participants

Understanding the Impact of Neighborhood Type on Physical Activity in Older Adults

Stanford University

NCT00094211

COMPLETED NA 870 participants

Clinician Counseling and Cultural Competency to Improve Hypertension Control and Therapy Adherence

Boston Medical Center

NCT00201149

COMPLETED Phase 4 777 participants

ISCHEMIA-Chronic Kidney Disease Trial

NYU Langone Health

NCT01985360

COMPLETED 750 participants

CV Disease in Adolescents With Type 2 Diabetes

Children's Hospital Medical Center, Cincinnati

NCT00114998

COMPLETED NA 727 participants

Assessing the Effectiveness of Concurrent Peer Review for Patients With Cardiovascular Disease and Diabetes

University of Rochester

NCT00508014

COMPLETED 715 participants

Heart Rate Variability and Sudden Cardiac Death

Columbia University

NCT00005235

COMPLETED NA 670 participants

Physician Uncertainty Reduction for Hypertension

Baylor College of Medicine

NCT00201084

COMPLETED 650 participants

Comparison of Two Methods to Diagnose Coronary Artery Disease

Johns Hopkins University

NCT00063531

COMPLETED 650 participants

Solutions for Atrial Fibrillation Edvocacy (SAFE)

American Pharmacists Association Foundation

NCT05067114

COMPLETED NA 646 participants

Reducing Disparities in Primary Prevention of Cardiovascular Disease

Northwestern University

NCT01610609

COMPLETED Phase 2 600 participants

Promoting Healthy Lifestyles Among Firefighters

Oregon Health and Science University

NCT00006181

COMPLETED 581 participants

Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)

CardioDx

NCT01117506

COMPLETED NA 574 participants

Targeting of UnControlled Hypertension in Emergency Department

University of Illinois at Chicago

NCT03749499

COMPLETED NA 561 participants

LEAVE Safe With DOACs

University of Massachusetts, Worcester

NCT04068727

COMPLETED 552 participants

HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms

Edwards Lifesciences

NCT05009589

COMPLETED NA 509 participants

Assessment of Prospective CYP2C19 Genotype Guided Dosing of Anti-Platelet Therapy in Percutaneous Coronary Intervention

University of Pennsylvania

NCT02508116

COMPLETED NA 422 participants

Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal

Windber Research Institute

NCT01805492

COMPLETED NA 408 participants

Behavioral and Recovery Support for 30 Day Post-Discharge Care

Laguna Health

NCT05431894

COMPLETED NA 406 participants

Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise

Iowa State University

NCT03069092

COMPLETED 400 participants

Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial

CardioDx

NCT00583297

COMPLETED Phase 2 389 participants

Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery

Duke University

NCT00041392

COMPLETED NA 355 participants

Reducing Risk Factors in Peripheral Arterial Disease

Northwestern University

NCT00217919

COMPLETED NA 350 participants

Impact of SomaSignal Tests on the Choice of Glucose-lowering Medications

University of Colorado, Denver

NCT05166382

COMPLETED NA 340 participants

pRESET for Occlusive Stroke Treatment

phenox

NCT03994822

COMPLETED 324 participants

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

University of Washington

NCT00880178

COMPLETED Phase 2 309 participants

Estrogen, HDL, and Coronary Heart Disease in Women

Tufts University

NCT00083824

COMPLETED Phase 2 308 participants

Evaluating the Effectiveness of a Computerized Medication Adherence System at Reducing Cardiovascular Disease Risk Factors

PHCC

NCT00796172

COMPLETED NA 300 participants

School-Based Intervention to Increase Physical Activity Among Adolescent Females

National Heart, Lung, and Blood Institute (NHLBI)

NCT00296101

COMPLETED 288 participants

Predictive Medicine Research. (PRE MED)

Emory University

NCT00336570

COMPLETED Phase 2 261 participants

Effects of Resistance and Aerobic Exercise on Cardiovascular Health

Duke University

NCT00275145

COMPLETED NA 257 participants

Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System

Cordis US

NCT01355406

COMPLETED NA 254 participants

Veterans Walk for Health Study

US Department of Veterans Affairs

NCT00123435

COMPLETED NA 250 participants

Pharmacist-led Group Medical Visits to Help With Diabetes Management

VA Office of Research and Development

NCT00554671

COMPLETED NA 250 participants

Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

Baylor Research Institute

NCT00224809

COMPLETED NA 245 participants

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase

Duke University

NCT06278883

COMPLETED NA 223 participants

Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study

University of Michigan

NCT04587882

COMPLETED NA 223 participants

Healthy Lifestyle Behavior Intervention for Latino Women

University of California, Los Angeles

NCT01333241

COMPLETED 210 participants

Epidemiology of Hypertensive Emergency

Columbia University

NCT00005240

COMPLETED Phase 4 200 participants

Diabetes Remote Intervention to improVe Use of Evidence-based Medications

Brigham and Women's Hospital

NCT06046560

COMPLETED 185 participants

Heartmatters Challenge - First Responders

Boston Heart Diagnostics

NCT03322046

COMPLETED NA 184 participants

Comparing TR Band to Statseal in Conjunction With TR Band

VA Long Beach Healthcare System

NCT03028025

COMPLETED NA 170 participants

Sapphire 3 CTO Study

OrbusNeich

NCT06358508

COMPLETED NA 167 participants

Strong People Strength Training Study

Cornell University

NCT04203563

COMPLETED 167 participants

Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers

University of Miami

NCT00253682

COMPLETED NA 159 participants

Worksite Wellness Within Long-term Care Facilities

University of Maryland, Baltimore

NCT04166643

COMPLETED NA 149 participants

Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians

Black Hills Center for American Indian Health

NCT00608387

COMPLETED Phase 3 120 participants

Comparison of Hematocrit Levels in Infant Heart Surgery

National Heart, Lung, and Blood Institute (NHLBI)

NCT00006183

COMPLETED 120 participants

Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk

National Heart, Lung, and Blood Institute (NHLBI)

NCT00613158

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Diseases Trial Landscape

304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).

Phase mix: 26 late (III/IV) vs 28 early (I/II).

Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Diseases?

PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.