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ClinicalTrials.gov 134 recruiting now full pipeline #27 of 28,707 conditions

Cardiovascular Diseases: full-pipeline trial registry

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

Corpus placement: #27 of 28,707 conditions by registered trial count.

304 US clinical trials · 134 currently recruiting · #27 of 28,707 conditions by registered trial count

Cardiovascular Diseases: 304 US clinical trials tracked, 134 recruiting.

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

Enrollment posture brief

Registry condition cardiovascular-diseases

OPEN 134 | RECR 44% | LATE 26 | EARLY 28 | RANK #27 | SPON 10

Nearest open-share peer: Suicide (44% recruiting · 93 trials)

Acute Myeloid Leukemia51.8%Chronic Pain46%Cardiovascular Diseases (thi…44%HIV35.9%COVID-1922.7%
Open-enrollment share among volume-matched conditions near Cardiovascular Diseases

Cardiovascular Diseases lists 134 open slots (44% of 304 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Cardiovascular Diseases on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Cardiovascular Diseases is recruiting above its size-band peers.

    134 of 304 indexed trials (44.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Cardiovascular Diseases trials is spread across many organizations.

    Duke University accounts for 10 of 304 trials (3.3%). 159 distinct sponsors appear on at least one study for this condition label.

  3. Typical Cardiovascular Diseases enrolment sits around 200 participants.

    Median target enrolment is 200 among the 301 trials that report a genuine target (sentinel values excluded). 101 of those (33.6%) plan for fewer than 100 participants.

  4. Cardiovascular Diseases research is mostly interventional.

    225 interventional and 79 observational studies make up this index (74% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 110Phase 218Phase 313Phase 413

Open and recent trials

304 total, page 5 of 7

COMPLETED Phase 3 911 participants

IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

Tufts Medical Center

NCT00091507

COMPLETED Phase 2 905 participants

A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)

Eli Lilly and Company

NCT00059215

COMPLETED 896 participants

Understanding the Impact of Neighborhood Type on Physical Activity in Older Adults

Stanford University

NCT00094211

COMPLETED NA 870 participants

Clinician Counseling and Cultural Competency to Improve Hypertension Control and Therapy Adherence

Boston Medical Center

NCT00201149

COMPLETED Phase 4 777 participants

ISCHEMIA-Chronic Kidney Disease Trial

NYU Langone Health

NCT01985360

COMPLETED 750 participants

CV Disease in Adolescents With Type 2 Diabetes

Children's Hospital Medical Center, Cincinnati

NCT00114998

COMPLETED NA 727 participants

Assessing the Effectiveness of Concurrent Peer Review for Patients With Cardiovascular Disease and Diabetes

University of Rochester

NCT00508014

COMPLETED 715 participants

Heart Rate Variability and Sudden Cardiac Death

Columbia University

NCT00005235

COMPLETED NA 670 participants

Physician Uncertainty Reduction for Hypertension

Baylor College of Medicine

NCT00201084

COMPLETED 650 participants

Comparison of Two Methods to Diagnose Coronary Artery Disease

Johns Hopkins University

NCT00063531

COMPLETED 650 participants

Solutions for Atrial Fibrillation Edvocacy (SAFE)

American Pharmacists Association Foundation

NCT05067114

COMPLETED NA 646 participants

Reducing Disparities in Primary Prevention of Cardiovascular Disease

Northwestern University

NCT01610609

COMPLETED Phase 2 600 participants

Promoting Healthy Lifestyles Among Firefighters

Oregon Health and Science University

NCT00006181

COMPLETED 581 participants

Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)

CardioDx

NCT01117506

COMPLETED NA 574 participants

Targeting of UnControlled Hypertension in Emergency Department

University of Illinois at Chicago

NCT03749499

COMPLETED NA 561 participants

LEAVE Safe With DOACs

University of Massachusetts, Worcester

NCT04068727

COMPLETED 552 participants

HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms

Edwards Lifesciences

NCT05009589

COMPLETED NA 509 participants

Assessment of Prospective CYP2C19 Genotype Guided Dosing of Anti-Platelet Therapy in Percutaneous Coronary Intervention

University of Pennsylvania

NCT02508116

COMPLETED NA 422 participants

Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal

Windber Research Institute

NCT01805492

COMPLETED NA 408 participants

Behavioral and Recovery Support for 30 Day Post-Discharge Care

Laguna Health

NCT05431894

COMPLETED NA 406 participants

Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise

Iowa State University

NCT03069092

COMPLETED 400 participants

Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial

CardioDx

NCT00583297

COMPLETED Phase 2 389 participants

Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery

Duke University

NCT00041392

COMPLETED NA 355 participants

Reducing Risk Factors in Peripheral Arterial Disease

Northwestern University

NCT00217919

COMPLETED NA 350 participants

Impact of SomaSignal Tests on the Choice of Glucose-lowering Medications

University of Colorado, Denver

NCT05166382

COMPLETED NA 340 participants

pRESET for Occlusive Stroke Treatment

phenox

NCT03994822

COMPLETED 324 participants

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

University of Washington

NCT00880178

COMPLETED Phase 2 309 participants

Estrogen, HDL, and Coronary Heart Disease in Women

Tufts University

NCT00083824

COMPLETED Phase 2 308 participants

Evaluating the Effectiveness of a Computerized Medication Adherence System at Reducing Cardiovascular Disease Risk Factors

PHCC

NCT00796172

COMPLETED NA 300 participants

School-Based Intervention to Increase Physical Activity Among Adolescent Females

National Heart, Lung, and Blood Institute (NHLBI)

NCT00296101

COMPLETED 288 participants

Predictive Medicine Research. (PRE MED)

Emory University

NCT00336570

COMPLETED Phase 2 261 participants

Effects of Resistance and Aerobic Exercise on Cardiovascular Health

Duke University

NCT00275145

COMPLETED NA 257 participants

Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System

Cordis US

NCT01355406

COMPLETED NA 254 participants

Veterans Walk for Health Study

US Department of Veterans Affairs

NCT00123435

COMPLETED NA 250 participants

Pharmacist-led Group Medical Visits to Help With Diabetes Management

VA Office of Research and Development

NCT00554671

COMPLETED NA 250 participants

Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

Baylor Research Institute

NCT00224809

COMPLETED NA 245 participants

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase

Duke University

NCT06278883

COMPLETED NA 223 participants

Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study

University of Michigan

NCT04587882

COMPLETED NA 223 participants

Healthy Lifestyle Behavior Intervention for Latino Women

University of California, Los Angeles

NCT01333241

COMPLETED 210 participants

Epidemiology of Hypertensive Emergency

Columbia University

NCT00005240

COMPLETED Phase 4 200 participants

Diabetes Remote Intervention to improVe Use of Evidence-based Medications

Brigham and Women's Hospital

NCT06046560

COMPLETED 185 participants

Heartmatters Challenge - First Responders

Boston Heart Diagnostics

NCT03322046

COMPLETED NA 184 participants

Comparing TR Band to Statseal in Conjunction With TR Band

VA Long Beach Healthcare System

NCT03028025

COMPLETED NA 170 participants

Sapphire 3 CTO Study

OrbusNeich

NCT06358508

COMPLETED NA 167 participants

Strong People Strength Training Study

Cornell University

NCT04203563

COMPLETED 167 participants

Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers

University of Miami

NCT00253682

COMPLETED NA 159 participants

Worksite Wellness Within Long-term Care Facilities

University of Maryland, Baltimore

NCT04166643

COMPLETED NA 149 participants

Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians

Black Hills Center for American Indian Health

NCT00608387

COMPLETED Phase 3 120 participants

Comparison of Hematocrit Levels in Infant Heart Surgery

National Heart, Lung, and Blood Institute (NHLBI)

NCT00006183

COMPLETED 120 participants

Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk

National Heart, Lung, and Blood Institute (NHLBI)

NCT00613158

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Named interventions

Most-linked intervention names on Cardiovascular Diseases records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
9 trials
Placebo Dietary supplement
4 trials
Aspirin Drug
3 trials
Corus CAD (ASGES) Diagnostic test
2 trials
Medication Drug
2 trials
Tendyne Mitral Valve System Device
2 trials
Social Determinants of Health Other
2 trials
Lifestyle Behavioral
2 trials

US sites by state

Facility locations filed on Cardiovascular Diseases trials. A trial with sites in several states counts in each.

California 60 trials
Massachusetts 38 trials
New York 37 trials
Pennsylvania 36 trials
Illinois 33 trials
Florida 30 trials
Minnesota 28 trials
Georgia 27 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Cardiovascular Diseases page

304 registered trials, 134 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 134 Cardiovascular Diseases trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Duke University sponsors the most Cardiovascular Diseases trials on record, review their full trial history before evaluating a specific study. See Duke University's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cardiovascular Diseases condition card totals 304 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.