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ClinicalTrials.gov 134 recruiting now official registry

Cardiovascular Diseases clinical trials

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

304 US clinical trials · 134 currently recruiting

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

The research picture

Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.

134
recruiting participants now
44%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
10
top sponsor: Duke University
Phase 110Phase 218Phase 313Phase 413

Active & Recent Trials

304 total, page 6 of 7

COMPLETED Phase 3 118 participants

Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)

University of California, San Francisco

NCT03207945

COMPLETED NA 116 participants

Best Rest: Rest Time Before Blood Pressure Measurement Trial

Johns Hopkins University

NCT04031768

COMPLETED 110 participants

Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen

Thomas Jefferson University

NCT03646370

COMPLETED NA 108 participants

Effect of Korean Red Ginseng Extract on Blood Flow in Healthy Adults

Korea Ginseng Corporation

NCT06236243

COMPLETED NA 101 participants

Clinical Use Cases Assessment of the Gabi System in Young Children With Underlying Medical Conditions (BRIDGE Study)

Gabi SmartCare

NCT05319236

COMPLETED 100 participants

Distributed Registry

Stanford University

NCT03898570

COMPLETED 100 participants

Mil Familias-Santa Barbara's Operational Pilot to Understand Diabetes in the Latino Community

Sansum Diabetes Research Institute

NCT03736486

COMPLETED NA 100 participants

Pilot Guaranteed Income Study, Philadelphia, April 2023

University of Pennsylvania

NCT05838027

COMPLETED Phase 4 87 participants

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

University of Maryland, Baltimore

NCT03823911

COMPLETED NA 87 participants

Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers

Duke University

NCT01343810

COMPLETED NA 85 participants

The FAITH! Trial: A mHealth Intervention to Improve Cardiovascular Health Among African-Americans

Mayo Clinic

NCT03777709

COMPLETED NA 80 participants

Hoosier Sport: Refining and Implementing a Sustainable Campus-Community Partnership in Rural Indiana

Indiana University

NCT06602596

COMPLETED Early Phase 1 80 participants

The Effect of Vitamin D Statues on Endothelial Function

University of Wisconsin, Madison

NCT01049048

COMPLETED NA 71 participants

Evaluation of a Lifestyle Medicine Practice

Ohio University

NCT03739034

COMPLETED Phase 4 70 participants

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Florida Atlantic University

NCT00272311

COMPLETED Phase 1 67 participants

Effects of NT-0796 in Obese Participants at Risk of Cardiovascular Disease

NodThera Limited

NCT06129409

COMPLETED Phase 2 66 participants

Pistachios Blood Sugar Control, Heart and Gut Health

Penn State University

NCT04056208

COMPLETED NA 65 participants

Singing and Cardiovascular Health in Older Adults

Medical College of Wisconsin

NCT04121741

COMPLETED 60 participants

The Singing Heart Study

Medical College of Wisconsin

NCT03805529

COMPLETED Phase 2 55 participants

Antiplatelet Therapy in HIV

NYU Langone Health

NCT02559414

COMPLETED Phase 4 52 participants

Impact of Statin Therapy on Adaptations to Aerobic Exercise

University of Kansas Medical Center

NCT03360916

COMPLETED NA 50 participants

Eggs as Part of a Healthy Breakfast

University of Connecticut

NCT02297464

COMPLETED NA 50 participants

Comparing Perclose to Statseal With Perclose in Transcatheter Aortic Valve Replacement Arteriotomy Closure

University of California, Los Angeles

NCT05637970

COMPLETED 47 participants

Effect of Diet on Vascular Disease in Pre-Menopausal Women

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00484861

COMPLETED Phase 4 46 participants

Oral Contraceptives in the Metabolic Syndrome

Virginia Commonwealth University

NCT00205504

COMPLETED Phase 4 45 participants

Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D)

University of Michigan

NCT02973477

COMPLETED NA 45 participants

ObeSity and Jobs in SoCioeconomically Disadvantaged CommUnities: A Randomized CLinical Precision Public HealTh Intervention --The SCULPT-Job Study

University of California, San Francisco

NCT04709549

COMPLETED NA 40 participants

NightWare and Cardiovascular Health in Adults With PTSD

University of Colorado, Denver

NCT05365607

COMPLETED NA 40 participants

Growing Healthy Hearts: An Online Gardening Program for Adults With Risk Factors for Cardiovascular Disease

Milton S. Hershey Medical Center

NCT05720611

COMPLETED NA 40 participants

Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery

Dartmouth-Hitchcock Medical Center

NCT04481737

COMPLETED NA 38 participants

SWAP-MEAT: Study With Appetizing Plant Food - Meat Eating Alternatives Trial

Stanford University

NCT03718988

COMPLETED NA 35 participants

PE Audit and Feedback Pilot Study

University of California, Berkeley

NCT05509803

COMPLETED NA 35 participants

The Impact of Consumption of Eggs in the Context of Plant-Based Diets on Endothelial Function, Diet Quality, and Cardio-Metabolic Risk Factors in Adults at Risk for Type 2 Diabetes

Griffin Hospital

NCT04316429

COMPLETED NA 34 participants

Motivational Interviewing and Cognitive Behavioral Therapy-based Intervention for Cardiovascular Disease Prevention Amongst American Indians With Diabetic and Depressive Symptoms

University of Washington

NCT01892124

COMPLETED NA 32 participants

Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome

Ohio State University

NCT03624569

COMPLETED NA 30 participants

Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers

Tufts University

NCT00175084

COMPLETED 27 participants

Blood Pressure First Medication Therapy Management

American Pharmacists Association Foundation

NCT04275934

COMPLETED NA 25 participants

Respiratory Strength Training in Cardiac Surgical Patients

University of Florida

NCT04887415

COMPLETED NA 24 participants

Nutrition360: Moving to Integrated and Holistic Disease Prevention Among Underserved Mississippians

University of Southern Mississippi

NCT06286618

COMPLETED 24 participants

Platelet Function on Abacavir and Tenofovir

University of California, Los Angeles

NCT03081572

COMPLETED Phase 1 24 participants

MRI-Guided Balloon Angioplasty to Treat Blood Flow Blockage in the Legs

National Heart, Lung, and Blood Institute (NHLBI)

NCT00094783

COMPLETED NA 23 participants

Providing Personalized Health and Individual Lifestyle Enhancing Solutions (Prophiles) in CVD

NYU Langone Health

NCT03643146

COMPLETED NA 21 participants

Physical Activity and Pacemaker Study

Medical College of Wisconsin

NCT03052829

COMPLETED NA 21 participants

Dietary Fat and High-Density Lipoprotein (HDL) Metabolism-Effect of Carbohydrate and Fat Intake

Brigham and Women's Hospital

NCT01399632

COMPLETED Phase 4 21 participants

Pilot Study of Using Copeptin to Predict Response to Tolvaptan

University of North Carolina, Chapel Hill

NCT01346072

COMPLETED NA 20 participants

Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population

Leryn Reynolds

NCT04812392

COMPLETED NA 20 participants

Developing and Evaluating an Indoor Air Pollution Intervention Among Cardiovascular Patients: the AIRWISE Study

University of Montana

NCT06384625

COMPLETED NA 15 participants

Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH)

Penn State University

NCT05824741

COMPLETED NA 12 participants

Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) During Pregnancy

Penn State University

NCT05822531

COMPLETED NA 11 participants

Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Abbott Medical Devices

NCT03539458

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Diseases Trial Landscape

304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).

Phase mix: 26 late (III/IV) vs 28 early (I/II).

Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Diseases?

PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.