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ClinicalTrials.gov 134 recruiting now official registry

Cardiovascular Diseases clinical trials

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

304 US clinical trials · 134 currently recruiting

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

The research picture

Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.

134
recruiting participants now
44%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
10
top sponsor: Duke University
Phase 110Phase 218Phase 313Phase 413

Active & Recent Trials

304 total, page 4 of 7

ACTIVE NOT RECRUITING 750 participants

Integrating Abbott Point-of-Care Technologies and the Community Scientist Model to Support HbA1c Testing Per ADA

Sansum Diabetes Research Institute

NCT05000840

ACTIVE NOT RECRUITING NA 700 participants

A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities

University of Minnesota

NCT05671380

ACTIVE NOT RECRUITING 347 participants

Clinical Markers of Dysphagia in Cardiac Surgical Patients

University of Florida

NCT05304416

ACTIVE NOT RECRUITING NA 325 participants

CommunityRx-Cardiovascular Disease

University of North Carolina, Chapel Hill

NCT06264726

ACTIVE NOT RECRUITING NA 300 participants

RADIANCE Continued Access Protocol

ReCor Medical

NCT05017935

ACTIVE NOT RECRUITING NA 250 participants

Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD

atHeart Medical

NCT04591392

ACTIVE NOT RECRUITING NA 228 participants

2019-06 TRISCEND Study

Edwards Lifesciences

NCT04221490

ACTIVE NOT RECRUITING NA 225 participants

The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

ReCor Medical

NCT03614260

ACTIVE NOT RECRUITING 215 participants

Enhancing Rural Health Via Cardiovascular Telehealth for Rural Patients Implementation (E-VICTORS)

Wake Forest University Health Sciences

NCT04617834

ACTIVE NOT RECRUITING NA 200 participants

Behavioral Chronotype: Impact on Sleep and Metabolism

University of Chicago

NCT03647306

ACTIVE NOT RECRUITING 200 participants

Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer

Abramson Cancer Center at Penn Medicine

NCT05078190

ACTIVE NOT RECRUITING 200 participants

Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer

Abramson Cancer Center at Penn Medicine

NCT05096338

ACTIVE NOT RECRUITING NA 173 participants

Collaborate and Leverage Evidence in African American Rural Network

University of North Carolina, Chapel Hill

NCT06730633

ACTIVE NOT RECRUITING Phase 2 135 participants

A Study of Mosliciguat in PH-ILD

Pulmovant

NCT06635850

ACTIVE NOT RECRUITING NA 130 participants

Aventus Thrombectomy System Pulmonary Embolism Clinical Study

Inquis Medical

NCT05907564

ACTIVE NOT RECRUITING Phase 4 121 participants

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03520660

ACTIVE NOT RECRUITING NA 120 participants

Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation

University of Rochester

NCT04922281

ACTIVE NOT RECRUITING 112 participants

Cancer Survivor Cardiomyopathy Detection

Mayo Clinic

NCT05201014

ACTIVE NOT RECRUITING NA 106 participants

Mindfulness App Training for Cardiovascular Health

University of Pittsburgh

NCT06152185

ACTIVE NOT RECRUITING NA 103 participants

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Abbott Medical Devices

NCT03433274

ACTIVE NOT RECRUITING NA 90 participants

Team-based Care to Improve Hypertension

New York University

NCT05413252

ACTIVE NOT RECRUITING NA 60 participants

Re-thinking the Role of Peers And Training Patients [RePeAT]

University of Rochester

NCT05933655

ACTIVE NOT RECRUITING NA 45 participants

Effects of Dark Chocolate on the Risk Factors of Cardiovascular Diseases

San Diego State University

NCT06808282

ACTIVE NOT RECRUITING 45 participants

Estrogen and Microvascular Function

Medical College of Wisconsin

NCT06043310

ACTIVE NOT RECRUITING NA 42 participants

Dietary Approaches for Cardiovascular Health Study

University of Delaware

NCT05180435

ACTIVE NOT RECRUITING NA 37 participants

Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome

Rutgers, The State University of New Jersey

NCT06461273

ACTIVE NOT RECRUITING NA 36 participants

Watermelon Dose Response Blood Pressure Study

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT05892328

ACTIVE NOT RECRUITING NA 30 participants

Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption

University of California, Davis

NCT05321277

ACTIVE NOT RECRUITING NA 20 participants

Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial

Dana-Farber Cancer Institute

NCT07442578

ACTIVE NOT RECRUITING NA 20 participants

Enhancing Mental and Physical Health of Women Veterans

VA Office of Research and Development

NCT05050266

ACTIVE NOT RECRUITING Phase 1 17 participants

AB-1002 in Patients With Class III Heart Failure

AskBio

NCT04179643

ACTIVE NOT RECRUITING 15 participants

Circadian Rhythm Disruption in the Hospital Intensive Care Environment

University of Pennsylvania

NCT05828680

ACTIVE NOT RECRUITING NA 4 participants

A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation

Boston Scientific Corporation

NCT04147884

COMPLETED 714,582 participants

A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Janssen Research & Development

NCT03492580

COMPLETED 57,073 participants

Evaluation of VLER-Indiana Health Information Exchange Demonstration Project

VA Office of Research and Development

NCT01446705

COMPLETED NA 23,066 participants

Active Choice in the EHR to Promote Statin Therapy

University of Pennsylvania

NCT03271931

COMPLETED Phase 3 10,251 participants

Action to Control Cardiovascular Risk in Diabetes (ACCORD)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00000620

COMPLETED Phase 3 10,000 participants

Raloxifene Use for The Heart

Eli Lilly and Company

NCT00190593

COMPLETED NA 9,501 participants

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications

University of Colorado, Denver

NCT03973931

COMPLETED Phase 1 7,192 participants

Cooking for Health Optimization With Patients

Tulane University

NCT03443635

COMPLETED Phase 3 7,001 participants

Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest

National Heart, Lung, and Blood Institute (NHLBI)

NCT00047411

COMPLETED NA 5,179 participants

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

NYU Langone Health

NCT01471522

COMPLETED 4,350 participants

Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree

CardioDx

NCT00500617

COMPLETED NA 2,881 participants

Virtual World-Based Cardiac Rehabilitation

Mayo Clinic

NCT05897710

COMPLETED 2,763 participants

Understanding the Genetic and Hereditary Basis of Atherosclerosis

Wake Forest University Health Sciences

NCT00344292

COMPLETED Phase 3 2,201 participants

Occluded Artery Trial (OAT)

NYU Langone Health

NCT00004562

COMPLETED Phase 3 2,136 participants

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Duke University

NCT00023595

COMPLETED 1,395 participants

Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])

Northwestern University

NCT00626379

COMPLETED NA 1,049 participants

A 12 Month Site Randomized Trial in Adults With Type 2 Diabetes Mellitus and History of Cardiovascular Disease

Duke University

NCT03936660

COMPLETED NA 999 participants

Improving Albuminuria Screening Compliance Using a Smartphone Urinalysis Kit

Geisinger Clinic

NCT03470701

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Diseases Trial Landscape

304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).

Phase mix: 26 late (III/IV) vs 28 early (I/II).

Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Diseases?

PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.