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ClinicalTrials.gov 20 recruiting now official registry

Cardiovascular Disease clinical trials

20 of 137 indexed Cardiovascular Disease trials are currently recruiting.

137 US clinical trials · 20 currently recruiting

Cardiovascular Disease is the subject of 137 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.

The research picture

Cardiovascular Disease has 137 registered US clinical trials, 20 of them open to new participants right now, about 15% of the total.

20
recruiting participants now
15%
of trials open to enrollment
22
in Phase 3–4 (later-stage)
10
top sponsor: VA Office of Research and Development
Phase 17Phase 28Phase 314Phase 48

Active & Recent Trials

137 total, page 2 of 3

COMPLETED NA 489 participants

Heart to Health: A Combined Lifestyle and Medication Intervention to Reduce Cardiovascular Disease (CVD) Risk

University of North Carolina, Chapel Hill

NCT01245686

COMPLETED NA 479 participants

Unmet Social Needs Study

VA Office of Research and Development

NCT04977583

COMPLETED 469 participants

Redesigning Cardiac Surgery to Reduce Neurologic Injury

Dartmouth-Hitchcock Medical Center

NCT00432536

COMPLETED 400 participants

Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001874

COMPLETED NA 392 participants

The GoodNEWS Lifestyle Enhancement Program

University of Texas Southwestern Medical Center

NCT00669630

COMPLETED NA 360 participants

Feasibility and Impact of "ABCs of Diabetes" Self-Management Education Program at an Urban Public Library

Medstar Health Research Institute

NCT00822471

COMPLETED NA 339 participants

Heart-Healthy Lenoir Lifestyle Study

University of North Carolina, Chapel Hill

NCT01433484

COMPLETED 304 participants

Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women

San Diego State University

NCT00387166

COMPLETED NA 302 participants

Men Together Making a Difference: Health Promotion for Black Men

University of Pennsylvania

NCT02572414

COMPLETED NA 276 participants

Using Practice Facilitation in Primary Care Settings to Reduce Risk Factors for Cardiovascular Disease

NYU Langone Health

NCT02646488

COMPLETED Phase 4 248 participants

Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease

Massachusetts General Hospital

NCT00181818

COMPLETED NA 234 participants

Framingham State Food Study

Boston Children's Hospital

NCT02068885

COMPLETED 210 participants

Physical Health in Midlife: Influences of Adversity and Relationships Over Time

Beth Israel Deaconess Medical Center

NCT01853332

COMPLETED 200 participants

Handheld Echocardiography in Clinical Practice

Mayo Clinic

NCT01558518

COMPLETED NA 194 participants

Strong Hearts: Rural CVD Prevention

Cornell University

NCT02499731

COMPLETED NA 182 participants

A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome

Baptist Health South Florida

NCT01912209

COMPLETED 178 participants

Blood Vessel Study

National Institute of Environmental Health Sciences (NIEHS)

NCT01524549

COMPLETED NA 174 participants

Impact of Gum Infection on Heart Disease

Boston University

NCT00093236

COMPLETED 168 participants

Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01089114

COMPLETED 165 participants

RISE: A Clinical Evaluation of the StarClose™ Vascular Closure System

Abbott Medical Devices

NCT00736086

COMPLETED 160 participants

Heart Disease Risk Factors in Major Depression

National Institute of Mental Health (NIMH)

NCT00001969

COMPLETED Phase 2 152 participants

Reduction of Smoking in Cardiac Disease Patients

National Institute on Drug Abuse (NIDA)

NCT00469885

COMPLETED 150 participants

St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study

Essentia Health

NCT00631904

COMPLETED Phase 3 145 participants

High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly

Johns Hopkins University

NCT00127218

COMPLETED 129 participants

HIV and Cardiovascular Risk

Massachusetts General Hospital

NCT00465426

COMPLETED NA 128 participants

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients

Duke University

NCT02516332

COMPLETED Phase 2 125 participants

Metformin in Kidney Disease

VA Office of Research and Development

NCT02252081

COMPLETED NA 125 participants

Canola Oil Multi-Centre Intervention Trial II

University of Manitoba

NCT02029833

COMPLETED NA 120 participants

The Impact of Patient Involvement in Decision-Making About Heart Disease Prevention

University of North Carolina

NCT00315978

COMPLETED 120 participants

Understanding the Value of Community Vital Signs in Primary Care

Virginia Commonwealth University

NCT02512835

COMPLETED Phase 3 118 participants

Self-Management Addressing Heart Disease Risk Trial

US Department of Veterans Affairs

NCT00499096

COMPLETED NA 112 participants

The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee

Horizons International Peripheral Group

NCT02464501

COMPLETED NA 112 participants

Million Veteran Program Return of Actionable Results

VA Office of Research and Development

NCT04178122

COMPLETED 100 participants

Prevalence of Clopidogrel (Plavix) Resistance in Hemodialysis Patients

Northwell Health

NCT01865890

COMPLETED NA 100 participants

PREDHICT: Precision Recruitment and Engagement of Diabetics and Hypertensives in Clinical Studies

NYU Langone Health

NCT04286113

COMPLETED 100 participants

Study of Non-Invasive Regional Oxygen Saturations in Pediatric Patients Undergoing Cardiac Catheterization

Nonin Medical

NCT00939224

COMPLETED Phase 3 98 participants

Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus

Mayo Clinic

NCT00217061

COMPLETED 97 participants

A Complex Contraception Registry

University of California, San Diego

NCT02219269

COMPLETED 90 participants

Taste Perception and Chronic Disease Risk

Tufts University

NCT01023906

COMPLETED Phase 1 88 participants

Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus

MedImmune

NCT03654313

COMPLETED NA 86 participants

Patient-Centered Anticoagulation Self-Monitoring in Minority Patients

University of Illinois at Chicago

NCT02776566

COMPLETED Phase 1 81 participants

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Indiana University

NCT02685098

COMPLETED Phase 1 79 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a)

Amgen

NCT03626662

COMPLETED 74 participants

Lipids, Inflammation, and CV Risk in RA

Brigham and Women's Hospital

NCT02714881

COMPLETED Phase 3 73 participants

A Trial of Tadalafil and Glycemic Traits

Thomas J. Wang, MD

NCT01444651

COMPLETED NA 72 participants

Effects of Avocado Intake on the Nutritional Status of Families

University of California, San Diego

NCT02903433

COMPLETED NA 71 participants

Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction

Penn State University

NCT03064932

COMPLETED Phase 4 66 participants

Phosphate Lowering in CKD Trial

VA Office of Research and Development

NCT02209636

COMPLETED 65 participants

Validation of Peripheral Pressure Volume Loops and Ultrasound-derived "Cardiac Power" by Comparison With Invasive Left Ventricular Pressure Volume Loops

University of Virginia

NCT01750450

COMPLETED NA 65 participants

PREVENT Tool Study: Late Effects Clinic

Washington University School of Medicine

NCT04530825

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8
Phase 3 14
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Disease Trial Landscape

137 indexed Cardiovascular Disease studies · 20 recruiting (15%).

Phase mix: 22 late (III/IV) vs 15 early (I/II).

Top sponsor: VA Office of Research and Development (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Disease?

PlainTrial tracks 137 US clinical trials for Cardiovascular Disease, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.