Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Cardiovascular Disease: full-pipeline trial registry
20 of 138 indexed Cardiovascular Disease trials are currently recruiting.
Corpus placement: #83 of 28,707 conditions by registered trial count.
138 US clinical trials · 20 currently recruiting · #83 of 28,707 conditions by registered trial count
Cardiovascular Disease: 138 US clinical trials tracked, 20 recruiting.
Cardiovascular Disease is the subject of 138 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.
Enrollment posture brief
Registry condition cardiovascular-disease
OPEN 20 | RECR 14% | LATE 22 | EARLY 15 | RANK #83 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Acute Coronary Syndrome (15% recruiting · 41 trials)
Cardiovascular Disease lists 20 open slots (14% of 138 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Cardiovascular Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Cardiovascular Disease is recruiting below its size-band peers.
20 of 138 indexed trials (14.5%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Cardiovascular Disease trials is spread across many organizations.
VA Office of Research and Development accounts for 10 of 138 trials (7.2%). 84 distinct sponsors appear on at least one study for this condition label.
-
Typical Cardiovascular Disease enrolment sits around 120 participants.
Median target enrolment is 120 among the 138 trials that report a genuine target (sentinel values excluded). 59 of those (42.8%) plan for fewer than 100 participants.
-
Cardiovascular Disease splits between interventional and observational designs.
93 interventional and 45 observational studies make up this index (67.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
138 total, page 2 of 3
NCGENES: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing
University of North Carolina, Chapel Hill
NCT01969370
Heart to Health: A Combined Lifestyle and Medication Intervention to Reduce Cardiovascular Disease (CVD) Risk
University of North Carolina, Chapel Hill
NCT01245686
Unmet Social Needs Study
VA Office of Research and Development
NCT04977583
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Dartmouth-Hitchcock Medical Center
NCT00432536
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001874
The GoodNEWS Lifestyle Enhancement Program
University of Texas Southwestern Medical Center
NCT00669630
Feasibility and Impact of "ABCs of Diabetes" Self-Management Education Program at an Urban Public Library
Medstar Health Research Institute
NCT00822471
Heart-Healthy Lenoir Lifestyle Study
University of North Carolina, Chapel Hill
NCT01433484
Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women
San Diego State University
NCT00387166
Men Together Making a Difference: Health Promotion for Black Men
University of Pennsylvania
NCT02572414
Using Practice Facilitation in Primary Care Settings to Reduce Risk Factors for Cardiovascular Disease
NYU Langone Health
NCT02646488
Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease
Massachusetts General Hospital
NCT00181818
Framingham State Food Study
Boston Children's Hospital
NCT02068885
Physical Health in Midlife: Influences of Adversity and Relationships Over Time
Beth Israel Deaconess Medical Center
NCT01853332
Handheld Echocardiography in Clinical Practice
Mayo Clinic
NCT01558518
Strong Hearts: Rural CVD Prevention
Cornell University
NCT02499731
A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Baptist Health South Florida
NCT01912209
Blood Vessel Study
National Institute of Environmental Health Sciences (NIEHS)
NCT01524549
Impact of Gum Infection on Heart Disease
Boston University
NCT00093236
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01089114
RISE: A Clinical Evaluation of the StarClose™ Vascular Closure System
Abbott Medical Devices
NCT00736086
Heart Disease Risk Factors in Major Depression
National Institute of Mental Health (NIMH)
NCT00001969
Reduction of Smoking in Cardiac Disease Patients
National Institute on Drug Abuse (NIDA)
NCT00469885
St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study
Essentia Health
NCT00631904
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
Johns Hopkins University
NCT00127218
HIV and Cardiovascular Risk
Massachusetts General Hospital
NCT00465426
Exercise and Pharmacotherapy for Anxiety in Cardiac Patients
Duke University
NCT02516332
Metformin in Kidney Disease
VA Office of Research and Development
NCT02252081
Canola Oil Multi-Centre Intervention Trial II
University of Manitoba
NCT02029833
The Impact of Patient Involvement in Decision-Making About Heart Disease Prevention
University of North Carolina
NCT00315978
Understanding the Value of Community Vital Signs in Primary Care
Virginia Commonwealth University
NCT02512835
Self-Management Addressing Heart Disease Risk Trial
US Department of Veterans Affairs
NCT00499096
The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee
Horizons International Peripheral Group
NCT02464501
Million Veteran Program Return of Actionable Results
VA Office of Research and Development
NCT04178122
Prevalence of Clopidogrel (Plavix) Resistance in Hemodialysis Patients
Northwell Health
NCT01865890
PREDHICT: Precision Recruitment and Engagement of Diabetics and Hypertensives in Clinical Studies
NYU Langone Health
NCT04286113
Study of Non-Invasive Regional Oxygen Saturations in Pediatric Patients Undergoing Cardiac Catheterization
Nonin Medical
NCT00939224
Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus
Mayo Clinic
NCT00217061
A Complex Contraception Registry
University of California, San Diego
NCT02219269
Taste Perception and Chronic Disease Risk
Tufts University
NCT01023906
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
MedImmune
NCT03654313
Patient-Centered Anticoagulation Self-Monitoring in Minority Patients
University of Illinois at Chicago
NCT02776566
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation
Indiana University
NCT02685098
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a)
Amgen
NCT03626662
Lipids, Inflammation, and CV Risk in RA
Brigham and Women's Hospital
NCT02714881
A Trial of Tadalafil and Glycemic Traits
Thomas J. Wang, MD
NCT01444651
Effects of Avocado Intake on the Nutritional Status of Families
University of California, San Diego
NCT02903433
Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction
Penn State University
NCT03064932
Phosphate Lowering in CKD Trial
VA Office of Research and Development
NCT02209636
Validation of Peripheral Pressure Volume Loops and Ultrasound-derived "Cardiac Power" by Comparison With Invasive Left Ventricular Pressure Volume Loops
University of Virginia
NCT01750450
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 3 | 14 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Cardiovascular Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Cardiovascular Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Cardiovascular Disease page
138 registered trials, 20 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 20 Cardiovascular Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Cardiovascular Disease trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cardiovascular Disease condition card totals 138 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.