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Cardiovascular Disease clinical trials
20 of 137 indexed Cardiovascular Disease trials are currently recruiting.
137 US clinical trials · 20 currently recruiting
Cardiovascular Disease is the subject of 137 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 22 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 10 of these trials.
The research picture
Cardiovascular Disease has 137 registered US clinical trials, 20 of them open to new participants right now, about 15% of the total.
- 20
- recruiting participants now
- 15%
- of trials open to enrollment
- 22
- in Phase 3–4 (later-stage)
- 10
- top sponsor: VA Office of Research and Development
Active & Recent Trials
137 total, page 2 of 3
Heart to Health: A Combined Lifestyle and Medication Intervention to Reduce Cardiovascular Disease (CVD) Risk
University of North Carolina, Chapel Hill
NCT01245686
Unmet Social Needs Study
VA Office of Research and Development
NCT04977583
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Dartmouth-Hitchcock Medical Center
NCT00432536
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001874
The GoodNEWS Lifestyle Enhancement Program
University of Texas Southwestern Medical Center
NCT00669630
Feasibility and Impact of "ABCs of Diabetes" Self-Management Education Program at an Urban Public Library
Medstar Health Research Institute
NCT00822471
Heart-Healthy Lenoir Lifestyle Study
University of North Carolina, Chapel Hill
NCT01433484
Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women
San Diego State University
NCT00387166
Men Together Making a Difference: Health Promotion for Black Men
University of Pennsylvania
NCT02572414
Using Practice Facilitation in Primary Care Settings to Reduce Risk Factors for Cardiovascular Disease
NYU Langone Health
NCT02646488
Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease
Massachusetts General Hospital
NCT00181818
Framingham State Food Study
Boston Children's Hospital
NCT02068885
Physical Health in Midlife: Influences of Adversity and Relationships Over Time
Beth Israel Deaconess Medical Center
NCT01853332
Handheld Echocardiography in Clinical Practice
Mayo Clinic
NCT01558518
Strong Hearts: Rural CVD Prevention
Cornell University
NCT02499731
A Web-based Approach to Treating Cardiovascular Disease Risk in Employees With Metabolic Syndrome
Baptist Health South Florida
NCT01912209
Blood Vessel Study
National Institute of Environmental Health Sciences (NIEHS)
NCT01524549
Impact of Gum Infection on Heart Disease
Boston University
NCT00093236
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01089114
RISE: A Clinical Evaluation of the StarClose™ Vascular Closure System
Abbott Medical Devices
NCT00736086
Heart Disease Risk Factors in Major Depression
National Institute of Mental Health (NIMH)
NCT00001969
Reduction of Smoking in Cardiac Disease Patients
National Institute on Drug Abuse (NIDA)
NCT00469885
St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study
Essentia Health
NCT00631904
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
Johns Hopkins University
NCT00127218
HIV and Cardiovascular Risk
Massachusetts General Hospital
NCT00465426
Exercise and Pharmacotherapy for Anxiety in Cardiac Patients
Duke University
NCT02516332
Metformin in Kidney Disease
VA Office of Research and Development
NCT02252081
Canola Oil Multi-Centre Intervention Trial II
University of Manitoba
NCT02029833
The Impact of Patient Involvement in Decision-Making About Heart Disease Prevention
University of North Carolina
NCT00315978
Understanding the Value of Community Vital Signs in Primary Care
Virginia Commonwealth University
NCT02512835
Self-Management Addressing Heart Disease Risk Trial
US Department of Veterans Affairs
NCT00499096
The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee
Horizons International Peripheral Group
NCT02464501
Million Veteran Program Return of Actionable Results
VA Office of Research and Development
NCT04178122
Prevalence of Clopidogrel (Plavix) Resistance in Hemodialysis Patients
Northwell Health
NCT01865890
PREDHICT: Precision Recruitment and Engagement of Diabetics and Hypertensives in Clinical Studies
NYU Langone Health
NCT04286113
Study of Non-Invasive Regional Oxygen Saturations in Pediatric Patients Undergoing Cardiac Catheterization
Nonin Medical
NCT00939224
Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus
Mayo Clinic
NCT00217061
A Complex Contraception Registry
University of California, San Diego
NCT02219269
Taste Perception and Chronic Disease Risk
Tufts University
NCT01023906
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
MedImmune
NCT03654313
Patient-Centered Anticoagulation Self-Monitoring in Minority Patients
University of Illinois at Chicago
NCT02776566
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation
Indiana University
NCT02685098
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a)
Amgen
NCT03626662
Lipids, Inflammation, and CV Risk in RA
Brigham and Women's Hospital
NCT02714881
A Trial of Tadalafil and Glycemic Traits
Thomas J. Wang, MD
NCT01444651
Effects of Avocado Intake on the Nutritional Status of Families
University of California, San Diego
NCT02903433
Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction
Penn State University
NCT03064932
Phosphate Lowering in CKD Trial
VA Office of Research and Development
NCT02209636
Validation of Peripheral Pressure Volume Loops and Ultrasound-derived "Cardiac Power" by Comparison With Invasive Left Ventricular Pressure Volume Loops
University of Virginia
NCT01750450
PREVENT Tool Study: Late Effects Clinic
Washington University School of Medicine
NCT04530825
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 8 |
| Phase 3 | 14 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cardiovascular Disease Trial Landscape
137 indexed Cardiovascular Disease studies · 20 recruiting (15%).
Phase mix: 22 late (III/IV) vs 15 early (I/II).
Top sponsor: VA Office of Research and Development (10 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cardiovascular Disease?
PlainTrial tracks 137 US clinical trials for Cardiovascular Disease, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cardiovascular Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.